Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Brent W Simpson"'
Publikováno v:
eLife, Vol 9 (2020)
The asymmetric outer membrane (OM) of Gram-negative bacteria functions as a selective permeability barrier to the environment. Perturbations to OM lipid asymmetry sensitize the cell to antibiotics. As such, mechanisms involved in lipid asymmetry are
Externí odkaz:
https://doaj.org/article/6ad303f5bdb240e49a7ffa426ca234f2
Autor:
Brent W. Simpson, Marta Nieckarz, Victor Pinedo, Amanda B. McLean, Felipe Cava, M. Stephen Trent
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Gram-negative bacteria resist external stresses due to cell envelope rigidity, which is provided by two membranes and a peptidoglycan layer. The outer membrane (OM) surface contains lipopolysaccharide (LPS; contains O-antigen) or lipooligosa
Externí odkaz:
https://doaj.org/article/13a8c4be6c434440ac0374004e8ca3b6
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Gram-negative bacteria produce an asymmetric outer membrane (OM) that is particularly impermeant to many antibiotics and characterized by lipopolysaccharide (LPS) exclusively at the cell surface. LPS biogenesis remains an ideal target for th
Externí odkaz:
https://doaj.org/article/3ec61e3555304504af131d74e90b253e
Autor:
Brent W. Simpson, Karanbir S. Pahil, Tristan W. Owens, Emily A. Lundstedt, Rebecca M. Davis, Daniel Kahne, Natividad Ruiz
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT ATP-binding cassette (ABC) transporters constitute a large family of proteins present in all domains of life. They are powered by dynamic ATPases that harness energy from binding and hydrolyzing ATP through a cycle that involves the closing
Externí odkaz:
https://doaj.org/article/e5f9ae4be9c9430f83be36fa788bf4ff
Autor:
Brent W. Simpson, M. Stephen Trent
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Outer membrane biogenesis is a complex process for Gram-negative bacteria as the components are synthesized in the cytoplasm or at the inner membrane and then transported to the outer membrane. Stress pathways monitor and respond to problems
Externí odkaz:
https://doaj.org/article/784b8aece8ce4820bb9394d5aeca9a12
Autor:
Brent W. Simpson, Tristan W. Owens, Matthew J. Orabella, Rebecca M. Davis, Janine M. May, Sunia A. Trauger, Daniel Kahne, Natividad Ruiz
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT The surface of most Gram-negative bacteria is covered with lipopolysaccharide (LPS), creating a permeability barrier against toxic molecules, including many antimicrobials. To assemble LPS on their surface, Gram-negative bacteria must extrac
Externí odkaz:
https://doaj.org/article/70fd34c5f4c0484c83e80bbffb5c41d8
Publikováno v:
Molecular Microbiology. 114:200-213
Lipopolysaccharides (LPS) are essential envelope components in many Gram-negative bacteria and provide intrinsic resistance to antibiotics. LPS molecules are synthesized in the inner membrane and then transported to the cell surface by the LPS transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::874dab69d9471a709471ec43478fcc89
https://doi.org/10.1111/mmi.14506
https://doi.org/10.1111/mmi.14506
Autor:
M. Stephen Trent, Victor Pinedo, Amanda B. McLean, Felipe Cava, Marta Nieckarz, Brent W. Simpson
Publikováno v:
mBio
mBio, Vol 12, Iss 6 (2021)
mBio, Vol 12, Iss 6 (2021)
Gram-negative bacteria resist external stresses due to cell envelope rigidity, which is provided by two membranes and a peptidoglycan layer. The outer membrane (OM) surface contains lipopolysaccharide (LPS; contains O-antigen) or lipooligosaccharide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13e5da66c9c5402c25e63b449e43b7c
https://doi.org/10.1128/mbio.03099-21
https://doi.org/10.1128/mbio.03099-21
Publikováno v:
Journal of Bacteriology. 203
The cell surface of the Gram-negative cell envelope contains lipopolysaccharide (LPS) molecules, which form a permeability barrier against hydrophobic antibiotics. The LPS transport (Lpt) machine composed of LptB2FGCADE forms a proteinaceous trans-en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c07de8c356ddbe2a2d6df41980b535f
https://doi.org/10.1128/jb.00618-20
https://doi.org/10.1128/jb.00618-20
Publikováno v:
J Bacteriol
The cell surface of the Gram-negative cell envelope contains lipopolysaccharide (LPS) molecules, which form a permeability barrier against hydrophobic antibiotics. The LPS transport (Lpt) machine composed of LptB(2)FGCADE forms a proteinaceous transe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c612b3dd79ac943dfad9d1bf54b2503
https://pubmed.ncbi.nlm.nih.gov/33361195
https://pubmed.ncbi.nlm.nih.gov/33361195