Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Brent S. McKenzie"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population can develop in the thymus and in the peripheral tissues of the immune
Externí odkaz:
https://doaj.org/article/fd9bc801b57a4ba9a6794b2dcbbd0420
Autor:
Kimberly Stark, Tatiana Goncharov, Eugene Varfolomeev, Luke Xie, Hai Ngu, Ivan Peng, Keith R. Anderson, Erik Verschueren, Meena Choi, Donald S. Kirkpatrick, Amy Easton, Joshua D. Webster, Brent S. McKenzie, Domagoj Vucic, Baris Bingol
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Abstract RIP1 kinase-mediated inflammatory and cell death pathways have been implicated in the pathology of acute and chronic disorders of the nervous system. Here, we describe a novel animal model of RIP1 kinase deficiency, generated by knock-in of
Externí odkaz:
https://doaj.org/article/c403fe72c3fe41429f8c35b23860a00f
Autor:
Hans D. Brightbill, Eric Suto, Nicole Blaquiere, Nandhini Ramamoorthi, Swathi Sujatha-Bhaskar, Emily B. Gogol, Georgette M. Castanedo, Benjamin T. Jackson, Youngsu C. Kwon, Susan Haller, Justin Lesch, Karin Bents, Christine Everett, Pawan Bir Kohli, Sandra Linge, Laura Christian, Kathy Barrett, Allan Jaochico, Leonid M. Berezhkovskiy, Peter W. Fan, Zora Modrusan, Kelli Veliz, Michael J. Townsend, Jason DeVoss, Adam R. Johnson, Robert Godemann, Wyne P. Lee, Cary D. Austin, Brent S. McKenzie, Jason A. Hackney, James J. Crawford, Steven T. Staben, Moulay H. Alaoui Ismaili, Lawren C. Wu, Nico Ghilardi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Clinical trials of BAFF blockade with belimumab have shown partial efficacy for the treatment of systemic lupus erythematosus (SLE), so other therapeutic options are required. Here, the authors present a new small molecule inhibitor that targets NIK
Externí odkaz:
https://doaj.org/article/c1b21708fc0a4c58b4c58242d9d32c50
Autor:
Alexandra M Whiteley, Miguel A Prado, Ivan Peng, Alexander R Abbas, Benjamin Haley, Joao A Paulo, Mike Reichelt, Anand Katakam, Meredith Sagolla, Zora Modrusan, Dong Yun Lee, Merone Roose-Girma, Donald S Kirkpatrick, Brent S McKenzie, Steven P Gygi, Daniel Finley, Eric J Brown
Publikováno v:
eLife, Vol 6 (2017)
Ubiquilins (Ubqlns) are a family of ubiquitin receptors that promote the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for degradation. We carried out a proteomic analysis of a B cell lymphoma-derived cell line, BJAB
Externí odkaz:
https://doaj.org/article/42dd1cf6a73646cb83c9e311eb97172a
Autor:
Juan Zhang, Donghong Yan, Christopher C. Goodnow, Wendy Sandoval, Jian Payandeh, Bettina L. Lee, Qingling Li, Vicky Cho, Irma B. Stowe, Zora Modrusan, Lisa A. Miosge, Min Xu, Rohit Reja, Gözde Ulas, Merone Roose-Girma, Jing Kang, T. Daniel Andrews, Opher S. Kornfeld, Vishva M. Dixit, Karen O'Rourke, Joshua D. Webster, Wyne P. Lee, Brent S. McKenzie, Meredith Sagolla, Nobuhiko Kayagaki, Lucy X. Morris, Edward M. Bertram
Publikováno v:
Nature. 591:131-136
Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular molecules known as damage-associated molecular patterns (DAMPs) that propagate the inflammatory response1-3. The underlying mechanism of PMR,
Autor:
Youngsu Kwon, Avantika S. Chitre, Denise E. de Almeida Nagata, Karl L. Banta, Stephanie Mittman, Keith R. Anderson, Rafael Cubas, Kristin Harden Bowles, Patrícia de Almeida, Eugene Y. Chiang, Xiangnan Du, Søren Warming, Jane L. Grogan, Brent S. McKenzie
Publikováno v:
European Journal of Immunology. 50:891-902
CD96 is a member of the poliovirus receptor (PVR, CD155)-nectin family that includes T cell Ig and ITIM domain (TIGIT) and CD226. While CD96, TIGIT, and CD226 have important roles in regulating NK cell activity, and TIGIT and CD226 have also been sho
Autor:
Domagoj Vucic, Jonathan Maher, Tatiana Goncharov, Hua Zhang, Nina Ljumanovic, Brent S. McKenzie, Joshua D. Webster, Nick Corr, Youngsu Kwon, Sara F Santagostino, Summer Park, Snahel Patel, Eugene Varfolomeev, Jessica Preston, Adeyemi O Adedeji, Min Xu
Publikováno v:
Journal of Leukocyte Biology
Receptor interacting protein kinase 1 (RIP1) is a critical effector of inflammatory responses and cell death activation. Cell death pathways regulated by RIP1 include caspase‐dependent apoptosis and caspase‐independent necroptosis. The kinase act
Autor:
Timurs Maculins, Aditya Murthy, Cecile Chalouni, Junghyun Lim, Yasin Senbabaoglu, Ryan C. Kunz, Olga Vitek, Meena Choi, Mike Reichelt, Youngsu Kwon, Shilpa Rao, John R. Rohde, Anand Kumar Katakam, Patrick Chang, Donald S. Kirkpatrick, Ting Huang, Erik Verschueren, Trent Hinkle, Tsung-Heng Tsai, Ivan Dikic, Brent S. McKenzie, Brian K. Erickson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2ebcd43bbb7cc3f384051b4bee93602
https://doi.org/10.7554/elife.62320.sa2
https://doi.org/10.7554/elife.62320.sa2
Autor:
Baris Bingol, Kimberly L. Stark, Hai Ngu, Brent S. McKenzie, Donald S. Kirkpatrick, Luke Xie, Ivan Peng, Amy Easton, Erik Verschueren, Tatiana Goncharov, Eugene Varfolomeev, Keith R. Anderson, Domagoj Vucic, Meena Choi, Joshua D. Webster
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
RIP1 kinase-mediated inflammatory and cell death pathways have been implicated in the pathology of acute and chronic disorders of the nervous system. Here, we describe a novel animal model of RIP1 kinase deficiency, generated by knock-in of the kinas
Autor:
Patrick Caplazi, P. Bir Kohli, Joshua D. Webster, M. van Lookeren Campagne, Allie Maltzman, Gregory Hamilton, Wyne P. Lee, Evgeny Varfolomeev, Rina Fong, Brent S. McKenzie, Melissa R. Junttila, Swathi Sujatha-Bhaskar, Juan Zhang, Katherine E. Wickliffe, Patrick J. Lupardus, Debra L. Dugger, Domagoj Vucic, Snahel Patel, J.H. Cheng, Bianca M. Liederer, Kim Newton, Youngsu Kwon, Sreemathy Ramaswamy, Adam R. Johnson, Gauri Deshmukh
Publikováno v:
Cell Death and Differentiation
The kinase RIP1 acts in multiple signaling pathways to regulate inflammatory responses and it can trigger both apoptosis and necroptosis. Its kinase activity has been implicated in a range of inflammatory, neurodegenerative, and oncogenic diseases. H