Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Brent S. Lindsay"'
Publikováno v:
Tetrahedron. 56:497-505
The cytotoxic marine alkaloid ascididemin and various pyridine ring-E analogues have been synthesised in an attempt to determine the pharmaceutical utility and structure-activity requirements for the parent alkaloid. All compounds synthesised were ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::557882e7c5614c2b7bba93367862abe4
https://doi.org/10.1016/s0040-4020(99)01038-8
https://doi.org/10.1016/s0040-4020(99)01038-8
Autor:
David Ross Appleton, Brent R. Copp, Richard P. Hansen, Christopher J. Squire, George R. Clark, Brent S. Lindsay, Cliff E. F. Rickard
Publikováno v:
Synthetic Communications. 29:2665-2676
4-ethylthio- and 4-(4″-methylphenylthio)benzo[de][3,6]phenanthrolin-6(6H)-one have been synthesised in 4 steps from benzoquinone and then readily converted to the 4-amino (6d) and 4-methoxy (6c) analogues by nucleophilic substitution. Further elabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52a5917ba8ce017505d58a79b9604d53
https://doi.org/10.1080/00397919908086428
https://doi.org/10.1080/00397919908086428
Publikováno v:
Journal of Chemical Crystallography. 28:645-648
2-Bromoleptoclinidinone methanol solvate, C18H8BrN3O·CH4O, crystallizes in the orthorhombic space group Pbca with a = 15.7013(2), b = 7.3308(1), and c = 26.9326(1) A. The molecule is essentially planar, with the largest deviations occurring at bromi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a5c00c559d35c6d738bc63ee4ac1579
https://doi.org/10.1023/a:1022421328245
https://doi.org/10.1023/a:1022421328245
Publikováno v:
Synthetic Communications. 27:2587-2592
Conversion of tetracyclic quinone 1 to the cytotoxic pentacyclic alkaloid ascididemin (2) in 80% yield is achieved by reaction with paraformaldehyde and ammonium chloride in refluxing acetic acid. High yielding annelations are aiso observed for the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf78c0125c4608ffcfa04a5c02876e7
https://doi.org/10.1080/00397919708004128
https://doi.org/10.1080/00397919708004128
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:739-742
Comparison of the biological activities observed for ascididemin (2) and synthetic precursors/analogs has established the importance of N-8 in ring A, and a completed ring E, to topoisomerase II enzyme inhibition, human tumor cytotoxicity and antifun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48063a82424e8da115353b99b6c201a0
https://doi.org/10.1016/0960-894x(95)00106-4
https://doi.org/10.1016/0960-894x(95)00106-4
Autor:
Elaine S. Marshall, Hamish S. Sutherland, William A. Denny, Philip Kestell, Emma Richardson, Debra Greenhalgh, Catherine A. Gilchrist, Bruce C. Baguley, Angela Ding, In Young Hwang, Brent S. Lindsay, Wayne R. Joseph
Publikováno v:
Investigational new drugs. 30(5)
Purpose The human tumour suppressor protein p53 is mutated in nearly half of human tumours and most mutant proteins have single amino acid changes. Several drugs including the quinazoline derivative 1 (CP-31398) have been reported to restore p53 acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c949d169d48450ef6c10f20291ac113
https://pubmed.ncbi.nlm.nih.gov/21912889
https://pubmed.ncbi.nlm.nih.gov/21912889
Publikováno v:
ChemInform. 28
Conversion of tetracyclic quinone 1 to the cytotoxic pentacyclic alkaloid ascididemin (2) in 80% yield is achieved by reaction with paraformaldehyde and ammonium chloride in refluxing acetic acid. High yielding annelations are aiso observed for the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cdb180a3d4496426408393ecee18540
https://doi.org/10.1002/chin.199742264
https://doi.org/10.1002/chin.199742264
Autor:
Richard P. Hansen, George R. Clark, Brent R. Copp, Brent S. Lindsay, Cliff E. F. Rickard, David Ross Appleton, Christopher J. Squire
Publikováno v:
ChemInform. 30
4-ethylthio- and 4-(4″-methylphenylthio)benzo[de][3,6]phenanthrolin-6(6H)-one have been synthesised in 4 steps from benzoquinone and then readily converted to the 4-amino (6d) and 4-methoxy (6c) analogues by nucleophilic substitution. Further elabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0240f854613602df59ba3acd63ed0e79
https://doi.org/10.1002/chin.199938201
https://doi.org/10.1002/chin.199938201
Publikováno v:
ChemInform. 31
The title molecule, C17H10N2O2, is a synthetic precursor to the cytotoxic marine alkaloid ascididemin and is also structurally related to cleistopholine, a plant-derived antifungal agent. The molecule was found to be essentially planar with the only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64a4f9075138d4dcebd381d95beb6aa9
https://doi.org/10.1002/chin.200022031
https://doi.org/10.1002/chin.200022031
Publikováno v:
ChemInform. 31
The cytotoxic marine alkaloid ascididemin and various pyridine ring-E analogues have been synthesised in an attempt to determine the pharmaceutical utility and structure-activity requirements for the parent alkaloid. All compounds synthesised were ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63c5aa0fe49b8a86b28cbe0d30c0bb14
https://doi.org/10.1002/chin.200019198
https://doi.org/10.1002/chin.200019198