Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Brent Race"'
Autor:
Bradley R. Groveman, Katie Williams, Brent Race, Simote Foliaki, Tina Thomas, Andrew G. Hughson, Ryan O. Walters, Wenquan Zou, Cathryn L. Haigh
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 6, Pp 1193-1202 (2024)
Chronic wasting disease (CWD) is a cervid prion disease with unknown zoonotic potential that might pose a risk to humans who are exposed. To assess the potential of CWD to infect human neural tissue, we used human cerebral organoids with 2 different
Externí odkaz:
https://doaj.org/article/670bd8c3967d4f188129ce606ca89fd1
Autor:
Katie Williams, Simote T. Foliaki, Brent Race, Anna Smith, Tina Thomas, Bradley R. Groveman, Cathryn L. Haigh
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is a fatal neurodegenerative disease with currently no treatment options. Stem cell therapy for neurodegenerative diseases is emerging as a possible t
Externí odkaz:
https://doaj.org/article/76650160d49145ef9e878b0184a93c70
Autor:
Christina D Orrú, Bradley R Groveman, Andrew G Hughson, Tomás Barrio, Kachi Isiofia, Brent Race, Natalia C Ferreira, Pierluigi Gambetti, David A Schneider, Kentaro Masujin, Kohtaro Miyazawa, Bernardino Ghetti, Gianluigi Zanusso, Byron Caughey
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012175 (2024)
Prions or prion-like aggregates such as those composed of PrP, α-synuclein, and tau are key features of proteinopathies such as prion, Parkinson's and Alzheimer's diseases, respectively. Their presence on solid surfaces may be biohazardous under som
Externí odkaz:
https://doaj.org/article/e41f9f194a98464797ac114a7b488335
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0312837 (2024)
Prion diseases are transmissible, fatal neurologic diseases of mammals caused by the accumulation of mis-folded, disease associated prion protein (PrPd). Creutzfeldt-Jakob Disease (CJD) is the most common human prion disease and can occur by sporadic
Externí odkaz:
https://doaj.org/article/e2df01fa527a4089ab53111ab9bc9ed3
Autor:
Anne Ward, Forrest Jessop, Robert Faris, Jason Hollister, Daniel Shoup, Brent Race, Catharine M Bosio, Suzette A Priola
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0298095 (2024)
The PINK1/Parkin pathway of mitophagy has been implicated in the pathogenesis of Parkinson's disease. In prion diseases, a transmissible neurodegenerative disease caused by the misfolded and infectious prion protein (PrPSc), expression of both PINK1
Externí odkaz:
https://doaj.org/article/598e0040e30a4b93b9876823043878ef
Autor:
Bradley R. Groveman, Brent Race, Simote T. Foliaki, Katie Williams, Andrew G. Hughson, Chase Baune, Gianluigi Zanusso, Cathryn L. Haigh
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Human cerebral organoids (COs) are three-dimensional self-organizing cultures of cerebral brain tissue differentiated from induced pluripotent stem cells. We have recently shown that COs are susceptible to infection with different subtypes o
Externí odkaz:
https://doaj.org/article/3c5bd4382a434ac5b0e23d8a75101206
Autor:
Brent Race, Chase Baune, Katie Williams, James F. Striebel, Andrew G. Hughson, Bruce Chesebro
Publikováno v:
Veterinary Research, Vol 53, Iss 1, Pp 1-9 (2022)
Abstract Chronic wasting disease (CWD) is a prion disease of cervids including deer, elk, reindeer, and moose. Human consumption of cervids is common, therefore assessing the risk potential of CWD transmission to humans is critical. In a previous stu
Externí odkaz:
https://doaj.org/article/b984f435e5da496dbfd4f1678c8d4255
Autor:
Forrest Hoyt, Heidi G. Standke, Efrosini Artikis, Cindi L. Schwartz, Bryan Hansen, Kunpeng Li, Andrew G. Hughson, Matteo Manca, Olivia R. Thomas, Gregory J. Raymond, Brent Race, Gerald S. Baron, Byron Caughey, Allison Kraus
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
The authors report the near-atomic structure of the ex vivo aRML prion fibril. The comparison between this structure and the previously solved 263K prion fibril shows that both common and divergent features characterize these prion strains and their
Externí odkaz:
https://doaj.org/article/05a74e9b4a094ef891797aa49a2a0b86
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/ce719585b7a74ff686d0c8c1896b8de2
Autor:
Chase Baune, Bradley R Groveman, Andrew G Hughson, Tina Thomas, Barry Twardoski, Suzette Priola, Bruce Chesebro, Brent Race
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0290325 (2023)
Prion diseases are transmissible, fatal neurologic diseases that include Creutzfeldt-Jakob Disease (CJD) in humans, chronic wasting disease (CWD) in cervids, bovine spongiform encephalopathy (BSE) in cattle and scrapie in sheep. Prions are extremely
Externí odkaz:
https://doaj.org/article/4beb6980eb9a42c2962ac0f3ac764288