Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Brent R. Larsen"'
Autor:
Kuoting Wu, Clifford Wong, Margaret Neighbors, Erik E. Karrer, Yasuyuki Higashi, Madan M. Paidhungat, Steven J. Chapin, Steven H. Bass, Bruce H. Devens, Shinsuke Oshima, Margaret Reed, Brent R. Larsen, Yonghong Chen, Francisco A. Anderson, Marc Whitlow, Rujuta A. Bam, Sridhar Viswanathan, Rong A. Fan, Qian Zhang
Publikováno v:
Protein Engineering Design and Selection. 29:159-167
The CTLA4-Ig therapeutics abatacept and belatacept inhibit CD28-mediated T cell activation by binding CD80 (B7-1) and CD86 (B7-2) co-stimulatory ligands. Both compounds preferentially bind CD80, yet CD86 has been implicated as the dominant co-stimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16578a205d00bb45328a4431b02b5c0
https://doi.org/10.1093/protein/gzw002
https://doi.org/10.1093/protein/gzw002
Publikováno v:
International Journal of Peptide and Protein Research. 13:12-21
Experimental conditions and parameters involved in high performance liquid chromatography (HPLC) separations of the peptide hormone oxytocin and seven of its diastereoisomers, namely [1-hemi-D-cystine]-, [2-D-tyrosine]-, [4-D-glutamine]-, [5-D-aspara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b21824a0483eeedd45a7c045102c854
https://doi.org/10.1111/j.1399-3011.1979.tb01844.x
https://doi.org/10.1111/j.1399-3011.1979.tb01844.x
Autor:
Joerg Willuda, Wei Xia, Felipe Monteclaro, Takashi Sato, Sandra Biroc, Cynthia Gross, David R. Light, David Vogel, Jian-ming Gu, Brent R. Larsen, Ronald R. Cobb, Jianhuan Zhang, Andrzej Citkowicz, Deborah A. Zajchowski, David Kiewlich, Steve R. Roffler, Tara Heitner
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 1, Pp 18-30 (2006)
The EphA2 receptor tyrosine kinase has been shown to be over-expressed in cancer and a monoclonal antibody (mAb) that activates and down-modulates EphA2 was reported to inhibit the growth of human breast and lung tumor xenografts in nude mice. Reduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df64537ce8325a1287606bc8fcabc971
http://www.sciencedirect.com/science/article/pii/S1476558606800370
http://www.sciencedirect.com/science/article/pii/S1476558606800370
Autor:
Harald Dinter, Peter J. Kretschmer, Rick Lin, Debra Hudson, Doug Schneider, Pam Toy, Meredith Halks-Miller, Alicia Newton, Ronald R. Cobb, Gordon Parry, Bruno Alicke, Peter Bringmann, Georg A. Roth, Renate Parry, Jian-Ai Xuan, Helmut Klocker, Debbie Parkes, Sandra Biroc, Brent R. Larsen, Jason S. Lewis, Ying Zhu, Rick Harkins
Publikováno v:
Cancer Research. 65:8397-8405
Gene expression analysis showed that a human mindin homologue, mindin/RG-1, is expressed selectively in prostate tissues and that its expression level is elevated in some prostate tumors. Mindin/RG-1 protein expression is maintained in >80% of prosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f2d5e90ff1d7eaad3e6c6a9d0ea9d5
https://doi.org/10.1158/0008-5472.can-05-1203
https://doi.org/10.1158/0008-5472.can-05-1203
Autor:
Richard N. Harkins, Kelly Plummer, Oliver Ast, Peter Bringmann, Linda Cashion, Andrzej Citkowicz, Claudia Goldmann, Brent R. Larsen, Harald Petry
Publikováno v:
Analytical biochemistry. 376(2)
This study illustrates the application of asymmetrical flow field-flow fractionation (AF4) and light scattering analysis during the development of a gene delivery vehicle based on virus-like particles (VLPs) derived from the human polyoma JC virus. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a6c4051cee310d9e5748cf105f8384
https://pubmed.ncbi.nlm.nih.gov/18342613
https://pubmed.ncbi.nlm.nih.gov/18342613
Autor:
Shendong Yuan, Silke Finster, Marc Whitlow, Marc Adler, Karen May, Brent R. Larsen, Brad O. Buckman, Lorraine Kent, Raju Mohan, Imadul Islam, Judi Bryant
Publikováno v:
Biochemistry. 44(26)
This paper presents the crystal structure of porcine pancreatic carboxypeptidase B (pp-CpB) in complex with a variety of thiol-based inhibitors that were developed as antagonists of activated thrombin-activatable fibrinolysis inhibitor (TAFIa). Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679ec7c7c50598b063909a8448687280
https://pubmed.ncbi.nlm.nih.gov/15982000
https://pubmed.ncbi.nlm.nih.gov/15982000
Autor:
Silke Finster, Warren Manzana, Brent R. Larsen, Peter Bringmann, David R. Light, Sabine Schirm, Ronald R. Cobb, Eric Blasko, Jennifer Pearson, Katalin Kauser, John McClary, Sara Biancalana
Publikováno v:
Protein expression and purification. 42(2)
Prolyl-4-hydroxylase domain-containing enzymes (PHDs) mediate the oxygen-dependent regulation of the heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1). Under normoxic conditions, one of the subunits of HIF-1, HIF-1alpha, is hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e214cc9b42010b86a7f62e9bf6a4a44
https://pubmed.ncbi.nlm.nih.gov/15925519
https://pubmed.ncbi.nlm.nih.gov/15925519
Autor:
Richard N. Harkins, Susan Harvey, Gabor M. Rubanyi, Andrzej Citkowicz, Brent R. Larsen, Linda Cashion, Mary Rose Masikat, Perry Liu, Harald Petry, Hu Sheng Qian, Oliver Ast, Branka Mitrovic
Publikováno v:
Molecular Therapy. 13:S411-S412
The goal of the present study was to explore the tropism of Virus-Like Particles (VLP) originating from the human polyoma JC- virus (JCV) in vitro and in vivo. VLP have been known for several years to be a promising alternative to the existing viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9006aa29af696468858a44ea119113
https://doi.org/10.1016/j.ymthe.2006.08.1172
https://doi.org/10.1016/j.ymthe.2006.08.1172
Autor:
Andrezj Citkowicz, Harald Petry, Gabor M. Rubanyi, Richard N. Harkins, Linda Cashion, Oliver Ast, Brent R. Larsen
Publikováno v:
Molecular Therapy. 11:S68
Virus-like particles (VLP) have been known for several years to be a promising alternative to the existing viral and non-viral DNA delivery systems. VLPs are self-assembled structures composed only of proteins necessary for capsid formation and DNA p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f86d4754695c15078cff06629a1c565
https://doi.org/10.1016/j.ymthe.2005.06.175
https://doi.org/10.1016/j.ymthe.2005.06.175
Autor:
Harald Petry, Linda Cashion, Susan Harvey, Gabor M. Rubanyi, Brent R. Larsen, Andrzej Citkowicz, Katalin Kauser, Branka Mitrovic, Mary Rose Masikat, Richard N. Harkins, Oliver Ast
Publikováno v:
Molecular Therapy. 11:S68
Top of pageAbstract Gene therapy for treatment of neurological diseases is a rapidly emerging new field. Virus-Like Particles (VLP) originating from the human polyoma virus JCV are being evaluated as a delivery vector for the central nervous system (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26656c65011e50a049f633d2d37eb0a3
https://doi.org/10.1016/j.ymthe.2005.06.173
https://doi.org/10.1016/j.ymthe.2005.06.173