Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.

Autor: Corinne Ivaldi, Brent R Martin, Sylvie Kieffer-Jaquinod, Agnès Chapel, Thierry Levade, Jérôme Garin, Agnès Journet

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37187 (2012)

S-palmitoylation is a reversible post-translational modification important for controlling the membrane targeting and function of numerous membrane proteins with diverse roles in signalling, scaffolding, and trafficking. We sought to identify novel p

Externí odkaz: https://doaj.org/article/e394865cc6494fc6b4e629c28661eff1

A pilot clinical trial of a near‐infrared laser vaccine adjuvant: safety, tolerability, and cutaneous immune cell trafficking

Autor: Jeffrey A. Gelfand, Brent R. Martin, Yoshifumi Kimizuka, Satoshi Kashiwagi, Timothy Brauns, Elliot L. Botvinick, Mark C. Poznansky, Kristen Elkins, Kristen M. Kelly, Joseph J. Locascio, Rosalynn M. Nazarian, Blair Parry, Logan W Thomas, Skylar Korek

Publikováno v: Gelfand, JA; Nazarian, RM; Kashiwagi, S; Brauns, T; Martin, B; Kimizuka, Y; et al.(2018). A pilot clinical trial of a near-infrared laser vaccine adjuvant: safety, tolerability, and cutaneous immune cell trafficking.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, fj201801095R. doi: 10.1096/fj.201801095r. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5v0817vt

Many vaccines require adjuvants to enhance immunogenicity, but there are few safe and effective intradermal (i.d.) adjuvants. Murine studies have validated the potency of laser illumination of skin as an adjuvant for i.d. vaccination with advantages

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb3102758ad0944e880d4ba7dd1fcce
https://doi.org/10.1096/fj.201801095r

Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle

Autor: Brent R. Martin, Sang Joon Won

Publikováno v: ACS Chemical Biology. 13:1560-1568

S-palmitoylation is required for membrane anchoring, proper trafficking, and the normal function of hundreds of integral and peripheral membrane proteins. Previous bioorthogonal pulse-chase proteomics analyses identified Ras family GTPases, polarity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7916e9dee29db5917234fb0beab78a
https://doi.org/10.1021/acschembio.8b00157

HDAC8 Substrates Identified by Genetically Encoded Active Site Photocrosslinking

Autor: Brent R. Martin, Jeffrey E. Lopez, Jaimeen D. Majmudar, Carol A. Fierke, Sarah E. Haynes

Publikováno v: Journal of the American Chemical Society. 139:16222-16227

The histone deacetylase family comprises 18 enzymes that catalyze deacetylation of acetylated lysine residues, however, the specificity and substrate profile of each enzyme remains largely unknown. Due to transient enzyme-substrate interactions, conv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f032157bdb5665b892a01708324b26
https://doi.org/10.1021/jacs.7b07603

Chemoselective ratiometric imaging of protein S-sulfenylation

Autor: W. A. Walker, John E. Crellin, Sarah L. Veatch, Paul M. Jenkins, Matthew B. Stone, Christopher T.M.B. Tom, Lyanne Gomez-Rodriguez, Jeannie L. Hernandez, Hashim F. Motiwala, Dahvid Davda, Kristin J. Labby, Brent R. Martin, Yu Hsuan Kuo

Publikováno v: Chemical Communications. 53:7385-7388

Here we report a ratiometric fluorescent probe for chemoselective conjugation to sulfenic acids in living cells. Our approach couples an α-fluoro-substituted dimedone to an aminonaphthalene fluorophore (F-DiNap), which upon sulfenic acid conjugation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44bd5fbea5b47c6e342863b64007feb
https://doi.org/10.1039/c7cc02285a