Data from Enhanced Antitumor Efficacy of Low-Dose Etoposide with Oncolytic Herpes Simplex Virus in Human Glioblastoma Stem Cell Xenografts

Autor: Robert L. Martuza, Samuel D. Rabkin, Brent Passer, Hiroaki Wakimoto, Geon Woo Kim, Ryuichi Kanai, Tooba A. Cheema

Purpose: Glioblastoma (GBM) inevitably recurs despite surgery, radiation, and chemotherapy. A subpopulation of tumor cells, GBM stem cells (GSC), has been implicated in this recurrence. The chemotherapeutic agent etoposide is generally reserved for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29aab972dafaeffae3461fac05c1f90a
https://doi.org/10.1158/1078-0432.c.6519795

Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A

Autor: Christophe Cans, Nathalie Amzallag, Manuela Argentini, Adam Telerman, David Allanic, Dino Moras, V. F. Shalak, Marc Mirande, Bruno Goud, Virginie Crible, Giusy Fiucci, Vanessa Nancy-Portebois, Brent Passer, Robert Amson, Rowena Tufino

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2011, 100 (24), pp.13892-13897. ⟨10.1073/pnas.2335950100⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 100 (24), pp.13892-13897. ⟨10.1073/pnas.2335950100⟩

Recently, we demonstrated that the expression levels of the translationally controlled tumor protein (TCTP) were strongly down-regulated at the mRNA and protein levels during tumor reversion/suppression and by the activation of p53 and Siah-1. To bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b7789f4e93ff464e5da5f8c6f0fe56
https://doi.org/10.1073/pnas.2335950100

Analysis of HSV Oncolytic Virotherapy in Organotypic Cultures

Autor: Giulia Fulci, Brent Passer

Publikováno v: Gene Therapy of Cancer ISBN: 9781934115855

Tumor-selective replication-competent viral vectors, such as oncolytic herpes simplex virus (HSV) type I (HSV-1), represent an attractive strategy for tumor-based therapies because these viruses can replicate and spread in situ exhibiting cytopathic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63ca517d7f65c97639332813ae3c7308
https://doi.org/10.1007/978-1-59745-561-9_3

Siah-1 binds and regulates the function of Numb

Autor: Sylvie Prieur, Marcel Tuynder, Marie-Claude Gendron, Nathalie Amzallag-Elbaz, Moshe Oren, Alain Israël, Laurent Susini, Adam Telerman, Robert Amson, Tamar Juven-Gershon, Brent Passer, Nicolas Privat

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2001, 98 (26), pp.15067-15072. ⟨10.1073/pnas.261571998⟩
Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 (26), pp.15067-15072. ⟨10.1073/pnas.261571998⟩

The Drosophila Seven in absentia ( Sina ) gene product originally was described as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah-1, recently was found to be involved in p53-dependent and -independent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f51893fc6b6ed7257b8d411c590b0a
https://hal.archives-ouvertes.fr/hal-02412833