Výsledky vyhledávání - "Brent M, Steer"

In Vivo Function of Flow-Responsive Cis-DNA Elements of eNOS Gene: A Role for Chromatin-Based Mechanisms

Autor: Aravin N. Sukumar, Ranju Nair, Brent M. Steer, Manon Y M Feasson, Philip A. Marsden, Kyung Ha Ku, Eileen Tran, Michelle K. Dubinsky, Noeline Subramaniam, Britta J. Knight

Publikováno v: Circulation. 144:365-381

Background: eNOS (endothelial nitric oxide synthase) is an endothelial cell (EC)–specific gene predominantly expressed in medium- to large-sized arteries where ECs experience atheroprotective laminar flow with high shear stress. Disturbed flow with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a712bcca133a59e6174a7ac5d0c145
https://doi.org/10.1161/circulationaha.120.051078

Zobrazit plný text záznamu

Alternative Processing: Neuronal Nitric Oxide Synthase

Autor: Philip A. Marsden, Brent M Steer

Publikováno v: eLS

The human neuronal nitric oxide synthase (nNOS) gene is expressed from multiple promoters and is subject to alternate messenger ribonucleic acid (mRNA) processing. These complex molecular mechanisms contribute to regulating gene expression and functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05fc79eea323f8f76abf25e69d61ac2c
https://doi.org/10.1002/9780470015902.a0005040.pub3

Zobrazit plný text záznamu

Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions

Autor: Andrew Advani, Darren J. Kelly, Suzanne L. Advani, Renae M. Gow, Philip A. Marsden, P. Elizabeth Rakoczy, Kathryn White, Sally M. Marshall, Alison J. Cox, Yuan Zhang, Brent M. Steer, Richard E. Gilbert, Kerri Thai

Publikováno v: Proceedings of the National Academy of Sciences. 104:14448-14453

Inhibiting the actions of VEGF is a new therapeutic paradigm in cancer management with antiangiogenic therapy also under intensive investigation in a range of nonmalignant diseases characterized by pathological angiogenesis. However, the effects of V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad34bcbbdf2ec6296240c48b72e5dfe2
https://doi.org/10.1073/pnas.0703577104

Zobrazit plný text záznamu

Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice

Autor: Susan E. Quaggin, Maria Pia Rastaldi, Mei Ding, Matthias Kretzler, Brent M. Steer, Stuart J. Shankland, Volker H. Haase, Philip A. Marsden, Chengjin Li, Shiying Cui, Jeffrey W. Pippin, Clemens D. Cohen, Serge Jothy

Publikováno v: Nature Medicine. 12:1081-1087

Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome characterized by loss of renal function within days to weeks and by glomerular crescents on biopsy. The pathogenesis of this disease is unclear, but circulating factors are believed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c74525ef54808f8aa979bcc2b8ffd3e
https://doi.org/10.1038/nm1460

Zobrazit plný text záznamu

The Cell-specific Expression of Endothelial Nitric-oxide Synthase

Autor: Fotula Karantzoulis-Fegaras, Jason E. Fish, Brent M. Steer, Yvonne Chan, Cheryl D'Abreo, G. Brett Robb, Angela M. Keightley, Steven Lin, Anouk-Martine Teichert, Philip A. Marsden

Publikováno v: Journal of Biological Chemistry. 279:35087-35100

The basis for the endothelial cell-restricted expression of endothelial nitric-oxide synthase (eNOS) is not known. While transgenic promoter/reporter mice demonstrated endothelium cell-specific eNOS expression, we found robust expression of episomal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5afb235a8f5fcb1537518ac2e7f40f3
https://doi.org/10.1074/jbc.m405063200

Zobrazit plný text záznamu

Targeting Transgene Expression to Airway Epithelia and Submucosal Glands, Prominent Sites of Human CFTR Expression

Autor: Jonathan Plumb, Brent M. Steer, Yanxia Wen, Yu Hua Chow, Jim Hu, Zhan Lu, Manuel Buchwald

Publikováno v: Molecular Therapy. 2(4):359-367

Targeting therapeutic gene expression to disease-affected tissues is an essential component of effective and safe gene therapy. After birth, CFTR gene expression in human lungs is localized predominantly in the epithelial cells lining the upper airwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e012cea2be2ec2540d7c12953faa054

Zobrazit plný text záznamu

MicroRNA-145 Targeted Therapy Reduces Atherosclerosis

Autor: Praphulla C. Shukla, Fina Lovren, Brent M. Steer, Yi Pan, Philip A. Marsden, Krishna K. Singh, Mohammed Al-Omran, Hwee Teoh, Subodh Verma, Alistair J. Ingram, Nandini Gupta, Milan Gupta, Adrian Quan

Publikováno v: Circulation. 126

Background— MicroRNA are essential posttranscriptional modulators of gene expression implicated in various chronic diseases. Because microRNA-145 is highly expressed in vascular smooth muscle cells (VSMC) and regulates VSMC fate and plasticity, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344089da3f5cfd6b5d3246dbe18eca0d
https://doi.org/10.1161/circulationaha.111.084186

Zobrazit plný text záznamu

Endothelial nitric oxide synthase gene expression during murine embryogenesis: commencement of expression in the embryo occurs with the establishment of a unidirectional circulatory system

Autor: Anouk-Martine Teichert, Brent M. Steer, Myron I. Cybulsky, Angela M. Keightley, Su-Ning Zhu, G. Brett Robb, Jeremy A. Scott, Yu-Qing Zhou, Philip A. Marsden, Andre C. Schuh, Melissa Lem, S. Lee Adamson

Publikováno v: Circulation research. 103(1)

To elucidate the role of endothelial NO synthase (eNOS)-derived NO during mammalian embryogenesis, we assessed the expression of the eNOS gene during development. Using transgenic eNOS promoter/reporter mice (with β-galactosidase and green fluoresce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d525c21f740f0c9684334a2563f8441d
https://pubmed.ncbi.nlm.nih.gov/18556578

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání