Zobrazeno 1 - 10
of 7 140
pro vyhledávání: '"Brent M"'
Autor:
Brenton P. Munson, Michael Chen, Audrey Bogosian, Jason F. Kreisberg, Katherine Licon, Ruben Abagyan, Brent M. Kuenzi, Trey Ideker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Polypharmacology drugs—compounds that inhibit multiple proteins—have many applications but are difficult to design. To address this challenge we have developed POLYGON, an approach to polypharmacology based on generative reinforcement le
Externí odkaz:
https://doaj.org/article/55b169129e9145c5abf476bbec8ac7f5
Autor:
Sverre E. Kjeldsen, Brent M. Egan, Michel Burnier, Krzysztof Narkiewicz, Reinhold Kreutz, Giuseppe Mancia
Publikováno v:
Blood Pressure, Vol 33, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/f98dd0917e1b4c7c924aefefdd2bae09
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Mantle melt generation in response to glacial unloading has been linked to enhanced magmatic volatile release in Iceland and global eruptive records. It is unclear whether this process is important in systems lacking evidence of enhanced eru
Externí odkaz:
https://doaj.org/article/cd637d80f3a145d386174d6b7f68ce39
Publikováno v:
Organoids, Vol 2, Iss 4, Pp 239-255 (2023)
Organoids have emerged as a powerful tool for studying organ development, disease modeling, and drug discovery due to their ability to mimic the in vivo structure and function of organs in a three-dimensional in vitro model. During in vivo organ matu
Externí odkaz:
https://doaj.org/article/3adc396927154d549c396ce57e6b671b
Publikováno v:
ACS Omega, Vol 9, Iss 1, Pp 1287-1297 (2023)
Externí odkaz:
https://doaj.org/article/18172e44c2b54ba0badee3f1c300c557
Publikováno v:
Brain Sciences, Vol 14, Iss 10, p 999 (2024)
Background: Post-treatment side effects of chemotherapy can include cognitive deficits commonly known as Chemo-brain. The treatment of patients with Doxorubicin (DOX), one of the most widely used chemotherapeutic drugs in the treatment of cancer, can
Externí odkaz:
https://doaj.org/article/a248f947884f4f66b9bf1a4306663706
Autor:
João Vicente da Silveira, Carine Sangaleti, Cleber Camacho, Ana Alice Wolf Maciel, Maria Claudia Irigoyen, Thiago Macedo, José Jayme G. De Lima, Luciano F. Drager, Luiz Aparecido Bortolotto, Heno Ferreira Lopes, Madson Q. Almeida, Brent M. Egan, Fernanda Marciano Consolim-Colombo
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 11, Iss 10, p 299 (2024)
Primary aldosteronism (PA) is commonly associated with resistant hypertension. Biochemical tests can be clinically useful in the screening and diagnosis of primary aldosteronism. This study aimed to identify the cutoff values of aldosterone levels (A
Externí odkaz:
https://doaj.org/article/f54f78d1e2504a93984c339f55ccc3b5
Autor:
Brice Nzigou Mombo, Brent M. Bijonowski, Christopher A. Raab, Stephan Niland, Katrin Brockhaus, Marc Müller, Johannes A. Eble, Seraphine V. Wegner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many essential processes, including embryogenesis, wound healing and tissue organization, with dysregulation manifesting as tumorigenesis and metastasis. However,
Externí odkaz:
https://doaj.org/article/95180b5c11be448fa2645bf8fa403228
Autor:
Brent M. Troy, Kiesha Fraser Doh, Allison F. Linden, Yijin Xiang, Scott Gillespie, Maneesha Agarwal
Publikováno v:
Injury Epidemiology, Vol 10, Iss S1, Pp 1-9 (2023)
Abstract Background Unintentional injuries, including traumatic brain injuries (TBI), are the leading cause of pediatric morbidity and mortality in the USA. Helmet usage can reduce TBI incidence and severity; however, the epidemiology of pediatric TB
Externí odkaz:
https://doaj.org/article/26eb0075354242489d0ab3d9772320b5
Autor:
Jason M. Wood, Camilla Urbaniak, Ceth Parker, Nitin Kumar Singh, Season Wong, Arunkumar Arumugam, Dana J. Skorupa, Ashlyn Hemmah, Phoebe Laaguiby, Fathi Karouia, Brent M. Peyton, Scott Tighe, Kasthuri Venkateswaran
Publikováno v:
Frontiers in Ecology and Evolution, Vol 12 (2024)
Microbial diversity estimation involves extracting nucleic acids from intricate sample matrices. Preparing nucleic acid samples is time-consuming, necessitating effective cell lysis and obtaining pure, inhibitor-free nucleic acid purifications before
Externí odkaz:
https://doaj.org/article/f595ff73c82a4193b406034b869efa83