Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brent Lyda"'
Autor:
Libin Ye, Chris Neale, Adnan Sljoka, Brent Lyda, Dmitry Pichugin, Nobuyuki Tsuchimura, Sacha T. Larda, Régis Pomès, Angel E. García, Oliver P. Ernst, Roger K. Sunahara, R. Scott Prosser
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
G protein-coupled receptors (GPCRs) are membrane receptors and are important drug targets, whose regulation by cations is poorly understood. Here authors use NMR to elucidate effects of cations on functional states of the GPCR, adenosine A2Areceptor
Externí odkaz:
https://doaj.org/article/25e0679825f24b93877531f883a95c68
Autor:
Libin, Ye, Chris, Neale, Adnan, Sljoka, Brent, Lyda, Dmitry, Pichugin, Nobuyuki, Tsuchimura, Sacha T, Larda, Régis, Pomès, Angel E, García, Oliver P, Ernst, Roger K, Sunahara, R Scott, Prosser
Publikováno v:
Nature Communications
Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their mechanisms are poorly understood. Here, 19F NMR is used to delineate the effects of cations on functional states of the adenosine A2A GPCR. While Na+ reinforces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9019286364f425d6a50c6c6a2cae69dc
https://pubmed.ncbi.nlm.nih.gov/29636462
https://pubmed.ncbi.nlm.nih.gov/29636462
Publikováno v:
Arthritis & Rheumatology. 66:579-588
Objective The nuclear receptor retinoic acid receptor–related orphan nuclear receptor γ (RORγ; T cell–specific isoform RORγt) is a key regulator of Th17 cell differentiation, controlling the production of the inflammatory cytokine interleukin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6886335243e8ce70ca9d10a5296e745
https://doi.org/10.1002/art.38272
https://doi.org/10.1002/art.38272
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 66(3)
The nuclear receptor retinoic acid receptor-related orphan nuclear receptor γ (RORγ; T cell-specific isoform RORγt) is a key regulator of Th17 cell differentiation, controlling the production of the inflammatory cytokine interleukin-17 (IL-17). Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d257019b6a65a1611ceb32252a3dd61
https://pubmed.ncbi.nlm.nih.gov/24574218
https://pubmed.ncbi.nlm.nih.gov/24574218
Autor:
Mi Ra Chang, Brent Lyda, Theodore M. Kamenecka, Laura A. Solt, Thomas P. Burris, Janelle L. Lauer, Naresh Kumar, Patrick R. Griffin
Nuclear receptors (NRs) are ligand-regulated transcription factors that display canonical domain structure with highly conserved DNA-binding and ligand-binding domains. The identification of the endogenous ligands for several receptors remains elusiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c496d5117c3c72d253c376194bf796
https://europepmc.org/articles/PMC3331898/
https://europepmc.org/articles/PMC3331898/
Publikováno v:
The Journal of Immunology. 190:212.4-212.4
The nuclear receptor RORγ has been shown to play an essential role in the development of Th17 cells. Previously, it was reported that the potent and selective RORγ inverse agonist SR2211 was effective at modulating RORγ activity in cell culture. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d49c590d7ea1857215a4bcc0b2bb28c2
https://doi.org/10.4049/jimmunol.190.supp.212.4
https://doi.org/10.4049/jimmunol.190.supp.212.4
Publikováno v:
MedChemComm. 4:764
Nuclear receptors (NR) are ligand-regulated transcription factors that control the expression of target genes involved in a range of physiological processes such as development, metabolism, and immunity. The retinoic acid receptor-related orphan rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::089c8e50e6083338ca94fb2fbefc46a0
https://doi.org/10.1039/c3md00005b
https://doi.org/10.1039/c3md00005b