Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Brent L Nannenga"'
Autor:
Pascal Krotee, Jose A Rodriguez, Michael R Sawaya, Duilio Cascio, Francis E Reyes, Dan Shi, Johan Hattne, Brent L Nannenga, Marie E Oskarsson, Stephan Philipp, Sarah Griner, Lin Jiang, Charles G Glabe, Gunilla T Westermark, Tamir Gonen, David S Eisenberg
Publikováno v:
eLife, Vol 6 (2017)
hIAPP fibrils are associated with Type-II Diabetes, but the link of hIAPP structure to islet cell death remains elusive. Here we observe that hIAPP fibrils are cytotoxic to cultured pancreatic β-cells, leading us to determine the structure and cytot
Externí odkaz:
https://doaj.org/article/f0207c5ac18e49debe0019586fe78051
Publikováno v:
eLife, Vol 3 (2014)
MicroED is a recently developed method that uses electron diffraction for structure determination from very small three-dimensional crystals of biological material. Previously we used a series of still diffraction patterns to determine the structure
Externí odkaz:
https://doaj.org/article/f127022da7dc4abfa0e8386c3a47fb36
Publikováno v:
eLife, Vol 2 (2013)
We demonstrate that it is feasible to determine high-resolution protein structures by electron crystallography of three-dimensional crystals in an electron cryo-microscope (CryoEM). Lysozyme microcrystals were frozen on an electron microscopy grid, a
Externí odkaz:
https://doaj.org/article/a777cdf2777740819d275e4733e3fdb4
Publikováno v:
Journal of Structural Biology: X, Vol 9, Iss , Pp 100102- (2024)
Microcrystal electron diffraction (MicroED) has emerged as a powerful technique for unraveling molecular structures from microcrystals too small for X-ray diffraction. However, a significant hurdle arises with plate-like crystals that consistently or
Externí odkaz:
https://doaj.org/article/8535d678483245299ce21056f86413f3
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5727 (2009)
Misfolding- and aggregation-prone proteins underlying Parkinson's, Huntington's and Machado-Joseph diseases, namely alpha-synuclein, huntingtin, and ataxin-3 respectively, adopt numerous intracellular conformations during pathogenesis, including glob
Externí odkaz:
https://doaj.org/article/2ae34fd95bff4605a086c78e9aa13d5e
Autor:
Brent L. Nannenga
Publikováno v:
IUCrJ, Vol 11, Iss 1, Pp 7-8 (2024)
This commentary describes a novel method for serial electron diffraction data collection in electron crystallography, utilizing a scanning transmission electron microscope to rapidly obtain patterns with low radiation dose. This approach, demonstrate
Externí odkaz:
https://doaj.org/article/ad244f2f430f4aa3b221e773755b825f
Autor:
Ryan Puskar, Chloe Du Truong, Kyle Swain, Saborni Chowdhury, Ka-Yi Chan, Shan Li, Kai-Wen Cheng, Ting Yu Wang, Yu-Ping Poh, Yuval Mazor, Haijun Liu, Tsui-Fen Chou, Brent L. Nannenga, Po-Lin Chiu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Cryo-EM reveals an asymmetric bacterial photosynthetic supercomplex built upon a homodimeric reaction center core. The structure provides mechanistic insights into light excitation transfer and a possible evolutionary transition intermediate of photo
Externí odkaz:
https://doaj.org/article/ca1fde03a9924a1988079932a5dcdece
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Metabolomics has emerged as a powerful discipline to study complex biological systems from a small molecule perspective. The success of metabolomics hinges upon reliable annotations of spectral features obtained from MS and/or NMR. In spite of tremen
Externí odkaz:
https://doaj.org/article/830be7100f9e46d2a0f3a56764daae9a
Autor:
Sankarsan Biswas, Sayan Banerjee, Milan A. Shlain, Andrey A. Bardin, Rein V. Ulijn, Brent L. Nannenga, Andrew M. Rappe, Adam B. Braunschweig
Publikováno v:
Faraday Discussions. 241:266-277
Unique and orthogonal photomechanochemical and photosolvochemical stereoselective routes for cycloaddition of acenaphthylene with high yields of syn and anti products are reported.
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2021)
Structural characterization of small molecules is a crucial component of organic synthesis. In this work, we applied microcrystal electron diffraction (MicroED) to analyze the structure of the product of an enzymatic reaction that was intended to pro
Externí odkaz:
https://doaj.org/article/fdd1b25f424c417b89c4258541a6fc6b