Výsledky vyhledávání - "Brent Kleintop"

Akademický článek

Development and validation of a sensitive and robust chiral method for (R)-propylene oxide: From chiral gas chromatography to chiral liquid chromatography with pre-column derivatization

Autor: Brian Lingfeng He, Michelle Kubin, Yueer Shi, Brent Kleintop

Publikováno v: Journal of Chromatography Open, Vol 5, Iss , Pp 100141- (2024)

Propylene oxide (PO) is an important chemical commodity and a chiral building block to prepare pharmaceutical compounds. It is crucial to develop a sensitive and robust chiral method that can be used to assess the enantiomeric purity of PO and safegu

Externí odkaz: https://doaj.org/article/7af2e66860b24257aebef3a894228caa

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Advancing stereoisomeric separation of an atropisomeric Bruton's tyrosine kinase inhibitor by using sub-2 µm immobilized polysaccharide-based chiral columns in supercritical fluid chromatography

Autor: Nicole G. Kleinsorge, Brent Kleintop, Ling Zhang, Brian Lingfeng He

Publikováno v: Journal of chromatography. A. 1626

BMS-986142 is a Bruton's tyrosine kinase inhibitor under development to treat several disease types. The compound contains three chiral elements: one chiral center and two chiral axes, resulting in three potential atropisomeric impurities in its drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df6113acd820c4a7b844c647de9272b
https://pubmed.ncbi.nlm.nih.gov/32797816

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Suppression of peak tailing of phosphate prodrugs in reversed-phase liquid chromatography

Autor: Qinggang Wang, Jin Zhang, Thomas Raglione, Brent Kleintop

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 98:247-252

Peak tailing of phosphate prodrugs in acidic mobile phases was thoroughly investigated. The results indicated that both metal–phosphate interactions and silanophilic interactions contributed to the observed peak tailing. Column pretreatment with ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6411486d2b323fa33c803de4eab3b32
https://doi.org/10.1016/j.jpba.2014.05.027

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Peak purity assessment in a triple-active fixed-dose combination drug product related substances method using a commercial two-dimensional liquid chromatography system

Autor: Brent Kleintop, Jonathan G. Shackman

Publikováno v: Journal of Separation Science. 37:2688-2695

Pharmaceutical formulations containing multiple active components challenge the development of analytical methods, especially as the individual active ingredients diverge in their physicochemical properties. Establishing specificity, especially peak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ad3017b0043ad4a48e37c1b62f44377
https://doi.org/10.1002/jssc.201400515

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Regeneration of Tetrabutylammonium Ion-Pairing Reagent Distribution in a Gradient Elution of Reversed Phase Ion-Pair Chromatography

Autor: Jin Zhang, Frank P. Tomasella, Qinggang Wang, Thomas Raglione, Xiaozhong Liang, Brent Kleintop

Publikováno v: Journal of Chromatographic Science. 49:825-831

The regeneration of ion-pairing reagent distribution on liquid chromatography columns after gradient elution has been well recognized as the cause for long column equilibration time, a major drawback associated with gradient elution reverse phase ion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890fd9d35bd9d089195eda495bd1d674
https://doi.org/10.1093/chrsci/49.10.825

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Direct and indirect separations of five isomers of Brivanib Alaninate using chiral high-performance liquid chromatography☆

Autor: Brent Kleintop, Thomas Raglione, Yueer Shi, Brian Lingfeng He

Publikováno v: Journal of Chromatography B. 875:122-135

Brivanib Alaninate is a novel chiral prodrug possessing two stereogenic centers. Simultaneous HPLC separation of five isomers of Brivanib Alaninate was systematically investigated on a wide variety of polysaccharide-based chiral stationary phases (CS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50be0563d1083b59521e30d3087e5c38
https://doi.org/10.1016/j.jchromb.2008.08.022

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Differences in In Vitro Dissolution Rates Using Single-Point and Multi-Point Sampling

Autor: Barry Scheer, Khanh Ha, Shannon Phillips, Brent Kleintop, Limin Zhang, Bristol-Myers Squibb

Publikováno v: Dissolution Technologies. 14:27-31

INTRODUCTION In vitro dissolution testing is an important physicochemical tool used to measure drug release rates during both early and late stages of drug development. In both cases, a product-specific discriminating dissolution method is utilized a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4baa8bbd9df9c27ea62bb07a682d210a
https://doi.org/10.14227/dt140407p27

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Transition metal-induced degradation of a pharmaceutical compound in reversed-phase liquid chromatographic analysis

Autor: Brent Kleintop, Yande Huang, Jin Zhang, Qinggang Wang, Thomas Raglione, Brian Lingfeng He

Publikováno v: Journal of pharmaceutical and biomedical analysis. 111

Drug degradation that occurs in HPLC analysis, during either sample preparation or chromatographic separation, can greatly impact method robustness and result accuracy. In this work, we report a case study of drug dimerization in HPLC analysis where

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c933b4f51702821f7ed5119ddb1ad897
https://pubmed.ncbi.nlm.nih.gov/25916912

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