Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Brent J. Guppy"'
Autor:
Jamie Zagozewski, Stephanie Borlase, Brent J. Guppy, Ludivine Coudière-Morrison, Ghazaleh M. Shahriary, Victor Gordon, Lisa Liang, Stephen Cheng, Christopher J. Porter, Rhonda Kelley, Cynthia Hawkins, Jennifer A. Chan, Yan Liang, Jingjing Gong, Carolina Nör, Olivier Saulnier, Robert J. Wechsler-Reya, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
RNA sequencing of MEK inhibitor (selumetinib)-treated tumors reveals an upregulation of the JAK/STAT3 pathway, with combinatorial therapeutic strategies of JAK/STAT3 inhibitors and selumetinib investigated for the SHH subgroup of medulloblastoma.
Externí odkaz:
https://doaj.org/article/7089de720db644bf9d6c9ef8dd5e7822
Autor:
Philippe Henry, Surender Khatodia, Karan Kapoor, Britni Gonzales, Alexis Middleton, Kevin Hong, Aaron Hilyard, Steve Johnson, Davis Allen, Zachary Chester, Dan Jin, José Carlos Rodriguez Jule, Iain Wilson, Manu Gangola, Jason Broome, Deron Caplan, Dinesh Adhikary, Michael K. Deyholos, Michael Morgan, Oliver W. Hall, Brent J. Guppy, Cindy Orser
Publikováno v:
Journal of Cannabis Research, Vol 2, Iss 1, Pp 1-11 (2020)
Abstract Background The taxonomic classification of Cannabis genus has been delineated through three main types: sativa (tall and less branched plant with long and narrow leaves), indica (short and highly branched plant with broader leaves) and ruder
Externí odkaz:
https://doaj.org/article/9405951ac8cd47b0bc0b8edb2919ae6f
Publikováno v:
Cancers, Vol 13, Iss 5, p 1043 (2021)
Chromosome instability (CIN) is an enabling feature of oncogenesis associated with poor patient outcomes, whose genetic determinants remain largely unknown. As mitotic chromatin compaction defects can compromise the accuracy of chromosome segregation
Externí odkaz:
https://doaj.org/article/85f24b526c1c49df9380987d868efd31
Publikováno v:
Cancers, Vol 5, Iss 3, Pp 739-761 (2013)
Cancer is a leading cause of death throughout the World. A limitation of many current chemotherapeutic approaches is that their cytotoxic effects are not restricted to cancer cells, and adverse side effects can occur within normal tissues. Consequent
Externí odkaz:
https://doaj.org/article/7e02ab21c48b4a89a94385023fe613e0
Autor:
Derek M. van Pel, Irene J. Barrett, Yoko Shimizu, Babu V. Sajesh, Brent J. Guppy, Tom Pfeifer, Kirk J. McManus, Philip Hieter
Publikováno v:
PLoS Genetics, Vol 9, Iss 2 (2013)
Externí odkaz:
https://doaj.org/article/4541f3c0452a463297e0b6e7f1767a3b
Autor:
Dan Jin, Surender Khatodia, Alexis Middleton, Jose Carlos Rodriguez Jule, Deron Caplan, Philippe Henry, Brent J. Guppy, Britni Gonzales, Steve Johnson, Michael K. Deyholos, Kevin Hong, Karan Kapoor, Oliver W. Hall, Manu Gangola, Iain Wilso, Ernest Jason Broome, Zachary Chester, Michael Morgan, Cindy Orser, Aaron Hilyard, Davis Allen, Dinesh Adhikary
Publikováno v:
Journal of Cannabis Research, Vol 2, Iss 1, Pp 1-11 (2020)
Journal of Cannabis Research
Journal of Cannabis Research
Background The taxonomic classification of Cannabis genus has been delineated through three main types: sativa (tall and less branched plant with long and narrow leaves), indica (short and highly branched plant with broader leaves) and ruderalis (hei
Autor:
Brent J. Guppy, Kirk J. McManus
Publikováno v:
Cellular Oncology. 40:281-292
The identification of novel therapeutic targets that exploit the aberrant genetics driving oncogenesis is critical to better combat cancer. RNF20 is somatically altered in numerous cancers, and its diminished expression drives genome instability, a d
Publikováno v:
Current Molecular Biology Reports. 3:18-27
This review describes how disruptor of telomeric silencing 1-like (DOT1L) and histone H3 at lysine 79 (H3K79) methylation maintain genome stability under normal conditions and discusses the consequences of their dysregulation. We highlight the roles
Publikováno v:
Cancers, Vol 13, Iss 1043, p 1043 (2021)
Cancers
Volume 13
Issue 5
Cancers
Volume 13
Issue 5
Simple Summary Chromosome instability (CIN) promotes cancer initiation and progression, but its genetic origins remain largely unknown. As aberrant mitotic processes such as chromatin compaction defects can induce CIN, characterizing the molecular de
Autor:
Brent J. Guppy, Kirk J. McManus
Publikováno v:
Genetics
The loss of genome stability is an early event that drives the development and progression of virtually all tumor types. Recent studies have revealed that certain histone post-translational modifications exhibit dynamic and global increases in abunda