Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Brent J Guppy"'
Autor:
Derek M van Pel, Irene J Barrett, Yoko Shimizu, Babu V Sajesh, Brent J Guppy, Tom Pfeifer, Kirk J McManus, Philip Hieter
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003254 (2013)
Harnessing genetic differences between cancerous and noncancerous cells offers a strategy for the development of new therapies. Extrapolating from yeast genetic interaction data, we used cultured human cells and siRNA to construct and evaluate a synt
Externí odkaz:
https://doaj.org/article/7008e5b95da64f1da627f0bb212a729a
Autor:
Jamie Zagozewski, Stephanie Borlase, Brent J. Guppy, Ludivine Coudière-Morrison, Ghazaleh M. Shahriary, Victor Gordon, Lisa Liang, Stephen Cheng, Christopher J. Porter, Rhonda Kelley, Cynthia Hawkins, Jennifer A. Chan, Yan Liang, Jingjing Gong, Carolina Nör, Olivier Saulnier, Robert J. Wechsler-Reya, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
RNA sequencing of MEK inhibitor (selumetinib)-treated tumors reveals an upregulation of the JAK/STAT3 pathway, with combinatorial therapeutic strategies of JAK/STAT3 inhibitors and selumetinib investigated for the SHH subgroup of medulloblastoma.
Externí odkaz:
https://doaj.org/article/7089de720db644bf9d6c9ef8dd5e7822
Autor:
Philippe Henry, Surender Khatodia, Karan Kapoor, Britni Gonzales, Alexis Middleton, Kevin Hong, Aaron Hilyard, Steve Johnson, Davis Allen, Zachary Chester, Dan Jin, José Carlos Rodriguez Jule, Iain Wilson, Manu Gangola, Jason Broome, Deron Caplan, Dinesh Adhikary, Michael K. Deyholos, Michael Morgan, Oliver W. Hall, Brent J. Guppy, Cindy Orser
Publikováno v:
Journal of Cannabis Research, Vol 2, Iss 1, Pp 1-11 (2020)
Abstract Background The taxonomic classification of Cannabis genus has been delineated through three main types: sativa (tall and less branched plant with long and narrow leaves), indica (short and highly branched plant with broader leaves) and ruder
Externí odkaz:
https://doaj.org/article/9405951ac8cd47b0bc0b8edb2919ae6f
Autor:
Dan Jin, Surender Khatodia, Alexis Middleton, Jose Carlos Rodriguez Jule, Deron Caplan, Philippe Henry, Brent J. Guppy, Britni Gonzales, Steve Johnson, Michael K. Deyholos, Kevin Hong, Karan Kapoor, Oliver W. Hall, Manu Gangola, Iain Wilso, Ernest Jason Broome, Zachary Chester, Michael Morgan, Cindy Orser, Aaron Hilyard, Davis Allen, Dinesh Adhikary
Publikováno v:
Journal of Cannabis Research, Vol 2, Iss 1, Pp 1-11 (2020)
Journal of Cannabis Research
Journal of Cannabis Research
Background The taxonomic classification of Cannabis genus has been delineated through three main types: sativa (tall and less branched plant with long and narrow leaves), indica (short and highly branched plant with broader leaves) and ruderalis (hei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1194f2b6f5b79d47363a93504c213c7
https://doaj.org/article/9405951ac8cd47b0bc0b8edb2919ae6f
https://doaj.org/article/9405951ac8cd47b0bc0b8edb2919ae6f
Autor:
Brent J. Guppy, Kirk J. McManus
Publikováno v:
Cellular Oncology. 40:281-292
The identification of novel therapeutic targets that exploit the aberrant genetics driving oncogenesis is critical to better combat cancer. RNF20 is somatically altered in numerous cancers, and its diminished expression drives genome instability, a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3102af74f500469d0886b2c649ef8b6e
https://doi.org/10.1007/s13402-017-0323-y
https://doi.org/10.1007/s13402-017-0323-y
Publikováno v:
Current Molecular Biology Reports. 3:18-27
This review describes how disruptor of telomeric silencing 1-like (DOT1L) and histone H3 at lysine 79 (H3K79) methylation maintain genome stability under normal conditions and discusses the consequences of their dysregulation. We highlight the roles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b25795331dfdf5f0c3bd18de379618bf
https://doi.org/10.1007/s40610-017-0051-0
https://doi.org/10.1007/s40610-017-0051-0
Publikováno v:
Cancers, Vol 13, Iss 1043, p 1043 (2021)
Cancers
Volume 13
Issue 5
Cancers
Volume 13
Issue 5
Simple Summary Chromosome instability (CIN) promotes cancer initiation and progression, but its genetic origins remain largely unknown. As aberrant mitotic processes such as chromatin compaction defects can induce CIN, characterizing the molecular de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f28ccaf0081e12b9ec5ee789bcc143
https://doi.org/10.3390/cancers13051043
https://doi.org/10.3390/cancers13051043
Autor:
Brent J. Guppy, Kirk J. McManus
Publikováno v:
Genetics
The loss of genome stability is an early event that drives the development and progression of virtually all tumor types. Recent studies have revealed that certain histone post-translational modifications exhibit dynamic and global increases in abunda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69b5f1bb90fe37100a98319b63bb147
http://europepmc.org/articles/PMC4317652
http://europepmc.org/articles/PMC4317652
Autor:
Babu V. Sajesh1 babu@cc.umanitoba.ca, Brent J. Guppy1 umguppyb@cc.umanitoba.ca, Kirk J. McManus1 mcmanusk@cc.umanitoba.ca
Publikováno v:
Cancers. Sep2013, Vol. 5 Issue 3, p739-761. 23p.
Autor:
Kari M. Wosnitza, Jyothi Sethuraman, Georg Hausner, Shelly M. Rudski, Mohamed Hafez, Brent J. Guppy
Publikováno v:
Fungal Biology. 117:791-806
The mtDNA rnl-U7 region has been examined for the presence of introns in selected species of the genus Ceratocystis. Comparative sequence analysis identified group I and group II introns encoding single and double motif LAGLIDADG open reading frames
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d8655517560a6a600d09b6089ada15
https://doi.org/10.1016/j.funbio.2013.10.002
https://doi.org/10.1016/j.funbio.2013.10.002