Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Brent Holmes"'
1
Akademický článek
mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics
Autor: Brent Holmes, Angelica Benavides-Serrato, Jacquelyn T. Saunders, Sunil Kumar, Robert N. Nishimura, Joseph Gera
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 951-965 (2021)
The Hippo and mTOR signaling cascades are major regulators of cell growth and division. Aberrant regulation of these pathways has been demonstrated to contribute to gliomagenesis and result in enhanced glioblastoma proliferation and invasive characte
Externí odkaz: https://doaj.org/article/b01e8986ccf741549a1fff9a968ce1fb
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3
Akademický článek
Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma.
Autor: Angelica Benavides-Serrato, Jihye Lee, Brent Holmes, Kenna A Landon, Tariq Bashir, Michael E Jung, Alan Lichtenstein, Joseph Gera
Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0176599 (2017)
A small molecule which specifically blocks the interaction of Rictor and mTOR was identified utilizing a high-throughput yeast two-hybrid screen and evaluated as a potential inhibitor of mTORC2 activity in glioblastoma multiforme (GBM). In vitro, CID
Externí odkaz: https://doaj.org/article/dfba5d1f920047d6a7daff473ec6327c
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4
Akademický článek
Conditional astroglial Rictor overexpression induces malignant glioma in mice.
Autor: Tariq Bashir, Cheri Cloninger, Nicholas Artinian, Lauren Anderson, Andrew Bernath, Brent Holmes, Angelica Benavides-Serrato, Nesrin Sabha, Robert N Nishimura, Abhijit Guha, Joseph Gera
Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47741 (2012)
Hyperactivation of the mTORC2 signaling pathway has been shown to contribute to the oncogenic properties of gliomas. Moreover, overexpression of the mTORC2 regulatory subunit Rictor has been associated with increased proliferation and invasive charac
Externí odkaz: https://doaj.org/article/721fd34cf976430c8349f3a93c63e338
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5
Translation of circHGF RNA encodes an HGF protein variant promoting glioblastoma growth through stimulation of c-MET
Autor: Jacquelyn T. Saunders, Sunil Kumar, Angelica Benavides-Serrato, Brent Holmes, Kennedy E. Benavides, Muhammad T. Bashir, Robert N. Nishimura, Joseph Gera
Publikováno v: Journal of Neuro-Oncology. 163:207-218
Introduction HGF/c-MET signaling is a significant driver of glioblastoma (GBM) growth and disease progression. Unfortunately, c-MET targeted therapies have been found to be largely ineffective suggesting additional redundant mechanisms of c-MET activ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7af1f1b527e20811fcb6f4bcd6e455df
https://doi.org/10.1007/s11060-023-04331-5
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6
Data from Inhibition of SAPK2/p38 Enhances Sensitivity to mTORC1 Inhibition by Blocking IRES-Mediated Translation Initiation in Glioblastoma
Autor: Joseph Gera, Alan Lichtenstein, Janine Masri, Lauren Anderson, Teresa Ruegg, Nicholas Artinian, Brent Holmes, Tariq Bashir, Andrew Bernath, Cheri Cloninger
A variety of mechanisms confer hypersensitivity of tumor cells to the macrolide rapamycin, the prototypic mTORC1 inhibitor. Several studies have shown that the status of the AKT kinase plays a critical role in determining hypersensitivity. Cancer cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ab69775d46fd3d83a1f2aad6c02274
https://doi.org/10.1158/1535-7163.c.6535204
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