Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Brent H Cochran"'
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174775 (2017)
The growth factor and cytokine regulated transcription factor STAT3 is required for the self-renewal of several stem cell types including tumor stem cells from glioblastoma. Here we show that STAT3 inhibition leads to the upregulation of the histone
Externí odkaz:
https://doaj.org/article/a62399f4f404489e97069283aaade663
Autor:
Annette Shepard-Barry, Karel Pacak, Inna Lomakin, James F. Powers, Sun Jin Moon, Troy F. Langford, Yingbin Ouyang, Arthur S. Tischler, Brent H. Cochran, Richard W. Tothill, Hadley D. Sikes, Kassi T. Stein, Xue Zhang, James D. Baleja, Andrew D Pattison
Publikováno v:
Endocrine-Related Cancer
Tumors caused by loss-of-function mutations in genes encoding TCA cycle enzymes have been recently discovered and are now of great interest. Mutations in succinate dehydrogenase (SDH) subunits cause pheochromocytoma/paraganglioma (PCPG) and syndromic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89519ad1319245b825bf6d446638703f
https://doi.org/10.1530/erc-19-0474
https://doi.org/10.1530/erc-19-0474
Signaling network models are usually assembled from information in literature and expert knowledge or inferred from data. The goal of modeling is to gain mechanistic understanding of key signaling pathways and provide predictions on how perturbations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c844f164108fc401a60de6505c11776a
https://doi.org/10.1101/2021.07.04.451062
https://doi.org/10.1101/2021.07.04.451062
Publikováno v:
BioNLP@NAACL-HLT
The amount of biomedical literature has vastly increased over the past few decades. As a result, the sheer quantity of accessible information is overwhelming, and complicates manual information retrieval. Automated methods seek to speed up informatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95bef0a3e2f1b6ec98196b1a4f4a20f7
https://doi.org/10.18653/v1/2021.bionlp-1.26
https://doi.org/10.18653/v1/2021.bionlp-1.26
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783030601515
HCI (45)
HCI (45)
In this paper we present Jarvis, a multimodal explorer and navigation system for biocuration data, from both curated sources and text-derived datasets. This system harnesses voice and haptic control for a bioinformatic research context, specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a63d216d701da696103bcaf5b6eba89f
https://doi.org/10.1007/978-3-030-60152-2_9
https://doi.org/10.1007/978-3-030-60152-2_9
Publikováno v:
NLP4COVID@EMNLP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be544a8d16666180f9cae0e12b421b49
https://doi.org/10.18653/v1/2020.nlpcovid19-2.28
https://doi.org/10.18653/v1/2020.nlpcovid19-2.28
Autor:
Xue Zhang, Troy F. Langford, James D. Baleja, Hadley D. Sikes, Inna Lomakin, James F. Powers, Arthur S. Tischler, Kassi T. Stein, Brent H. Cochran
Publikováno v:
PMC
We describe a unique patient-derived xenograft (PDX) and cell culture model of succinate dehydrogenase-deficient gastrointestinal stromal tumor (SDH-deficient GIST), a rare mesenchymal tumor that can occur in association with paragangliomas in heredi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1758437a382bf1ada725ff1b9c21f1c4
https://doi.org/10.1530/erc-18-0115
https://doi.org/10.1530/erc-18-0115
Publikováno v:
Neuro-oncology Advances
Glioblastomas and glioblastoma stem cells are heterogeneous with respect to mutations, gene expression, and response to drugs. To make predictive responses of individual GBM stem cell lines to drugs, we have constructed a causal model of glioblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca14c7a750dbf119afe2f7da399da9cb
https://doi.org/10.1093/noajnl/vdab070.018
https://doi.org/10.1093/noajnl/vdab070.018
Publikováno v:
Cancer Research. 75:A2-65
Glioblastoma multiforme (GBM) is the most common and most aggressive tumor of the central nervous system, with a mean survival of only 12-14 months post diagnosis and treatment. A major reason for the poor prognosis of GBM is attributed to a small po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5822185c47166177fffd3a9e3d0b92c
https://doi.org/10.1158/1538-7445.transcagen-a2-65
https://doi.org/10.1158/1538-7445.transcagen-a2-65
Publikováno v:
Molecular cancer research : MCR. 16(1)
Glioblastoma multiforme (GBM) is the most common type of primary malignant brain cancer and has a very poor prognosis. A subpopulation of cells known as GBM stem-like cells (GBM-SC) have the capacity to initiate and sustain tumor growth and possess m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d2624603b71d757cea6602e635e334
https://pubmed.ncbi.nlm.nih.gov/28993509
https://pubmed.ncbi.nlm.nih.gov/28993509