Single-cell analysis of chromatin and expression reveals age- and sex-associated alterations in the human heart

Autor: David F. Read, Gregory T. Booth, Riza M. Daza, Dana L. Jackson, Rula Green Gladden, Sanjay R. Srivatsan, Brent Ewing, Jennifer M. Franks, Cailyn H. Spurrell, Anne Roshella Gomes, Diana O’Day, Aishwarya A. Gogate, Beth K. Martin, Haleigh Larson, Christian Pfleger, Lea Starita, Yiing Lin, Jay Shendure, Shin Lin, Cole Trapnell

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)

Abstract Sex differences and age-related changes in the human heart at the tissue, cell, and molecular level have been well-documented and many may be relevant for cardiovascular disease. However, how molecular programs within individual cell types v

Externí odkaz: https://doaj.org/article/c78d59de759c46328c8bc8b520ab680e

Single-cell analysis of chromatin and expression reveals age- and sex-associated alterations in the human heart

Autor: David F Read, Gregory T Booth, Riza M Daza, Dana L Jackson, Rula Green Gladden, Sanjay R Srivatsan, Brent Ewing, Jennifer M Franks, Cailyn H Spurrell, Anne Roshella Gomes, Diana O’Day, Aishwarya A Gogate, Beth K Martin, Lea Starita, Yiing Lin, Jay Shendure, Shin Lin, Cole Trapnell

Sex differences and age-related changes in the human heart at the tissue, cell, and molecular level have been well-documented and many may be relevant for cardiovascular disease. However, how molecular programs within individual cell types vary acros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78a5e2ad749e3c77922df18cb42ac3c8
https://doi.org/10.1101/2022.07.12.496461

The

Autor: Adam D, Warner, Louis, Gevirtzman, LaDeana W, Hillier, Brent, Ewing, Robert H, Waterston

Publikováno v: Genome research. 29(6)

We have used RNA-seq in Caenorhabditis elegans to produce transcription profiles for seven specific embryonic cell populations from gastrulation to the onset of terminal differentiation. The expression data for these seven cell populations, covering

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bbd1acfc69dab612a25c3b0ecd0d6ec0
https://pubmed.ncbi.nlm.nih.gov/31123079

Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project

Autor: L. Dick, Mark S. Guyer, D. Mecenas, William C. Spencer, Ming Sin Cheung, Sebastian D. Mackowiak, Tao Liu, A. Vielle, Abby F. Dernburg, Mitzi Morris, Bradley I. Arshinoff, Sheldon J. McKay, Amber Leahey, Thea A. Egelhofer, Lukas Habegger, Michael Snyder, Teruaki Takasaki, Roger P. Alexander, Stuart K. Kim, Ashish Agarwal, Ting Han, A. Leo Iniguez, Eric L. Van Nostrand, Gos Micklem, S. Taing, Ekta Khurana, Joel Rozowsky, Beijing Wu, Steven Henikoff, Adrian Carr, Philip Green, Angie S. Hinrichs, A. Muroyama, Jason D. Lieb, Paul Lloyd, Yaniv Lubling, P. Scheid, Kevin Y. Yip, Stefan R. Henz, Chao Cheng, Jiang Du, Mei Zhong, P. Alves, Elicia Preston, Zhi John Lu, Vishal Khivansara, Robert H. Waterston, J. Janette, C. Slightam, Frank J. Slack, David M. Miller, Eo Stinson, Nikolaus Rajewsky, Eran Segal, Jing Leng, Tony Hyman, R. Robilotto, C. Shou, Gunnar Rätsch, Eric C. Lai, Mihail Sarov, X. Shirley Liu, Isabel J. Latorre, A. Chateigner, Francois Gullier, Raymond K. Auerbach, W. James Kent, Sergio Contrino, Jeremy Brouillet, Lincoln Stein, T. Phippen, Andrea Sboner, Marco Mangone, Georg Zeller, Hoang Pham, Mark Gerstein, Michael J. MacCoss, Siew Loon Ooi, Cathleen M. Brdlik, D. Vafeados, Nicole L. Washington, Andreas Rechtsteiner, Peter J. Good, Susan Strome, Galt P. Barber, Kristin C. Gunsalus, John I. Murray, Valerie Reinke, Luke Dannenberg, Masaomi Kato, M. Jensen, X. Feng, John Kim, Kahn Rhrissorrakrai, H. Holster, Kohta Ikegami, Christina M. Whittle, M. Gutwein, Rachel Lyne, Wei Niu, Richard J.H. Smith, LaDeana W. Hillier, P. Kolasinska-Zwierz, Heidi Rosenbaum, Andréa C. Dosé, Xingliang Zhou, Marc D. Perry, Rajkumar Sasidharan, Rebecca F. Lowdon, Arshad Desai, Z. Zha, J. Brennan, Guilin Wang, P. Ruzanov, Brent Ewing, Gennifer E. Merrihew, Kim Rutherford, Reto Gassmann, Elise A. Feingold, Fabio Piano, Julie Ahringer, E. Kephart, Lucas Lochovsky, Sevinc Ercan, Suzanna E. Lewis, Ksenia Voronina, Koon-Kiu Yan, Jorja G. Henikoff, Hyunjin Shin, Hiram Clawson, Ghia Euskirchen

Publikováno v: Science. 330:1775-1787

From Genome to Regulatory Networks For biologists, having a genome in hand is only the beginning—much more investigation is still needed to characterize how the genome is used to help to produce a functional organism (see the Perspective by Blaxter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af1c9379c54f3982c93a77444265918c
https://doi.org/10.1126/science.1196914

Transcription-associated mutational asymmetry in mammalian evolution

Autor: Philip Green, Eric D. Green, Webb Miller, Brent Ewing, Pamela J. Thomas

Publikováno v: Nature Genetics. 33:514-517

Although mutation is commonly thought of as a random process, evolutionary studies show that different types of nucleotide substitution occur with widely varying rates that presumably reflect biases intrinsic to mutation and repair mechanisms1,2,3,4.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc0182b1caabe436acdd694cc5415fd
https://doi.org/10.1038/ng1103