Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Brent D. Weinberg"'
Autor:
Abinand C. Rejimon, Karthik K. Ramesh, Anuradha G. Trivedi, Vicki Huang, Eduard Schreibmann, Brent D. Weinberg, Lawrence R. Kleinberg, Hui-Kuo G. Shu, Hyunsuk Shim, Jeffrey J. Olson
Publikováno v:
Tomography, Vol 10, Iss 3, Pp 428-443 (2024)
Current diagnostic and therapeutic approaches for gliomas have limitations hindering survival outcomes. We propose spectroscopic magnetic resonance imaging as an adjunct to standard MRI to bridge these gaps. Spectroscopic MRI is a volumetric MRI tech
Externí odkaz:
https://doaj.org/article/96083e5061b6430facb2085954d78839
Autor:
Chi-Ming Chang, Karthik K. Ramesh, Vicki Huang, Saumya Gurbani, Lawrence R. Kleinberg, Brent D. Weinberg, Hyunsuk Shim, Hui-Kuo G. Shu
Publikováno v:
Tomography, Vol 9, Iss 3, Pp 942-954 (2023)
Histone deacetylase inhibitors (HDACis) are drugs that target the epigenetic state of cells by modifying the compaction of chromatin through effects on histone acetylation. Gliomas often harbor a mutation of isocitrate dehydrogenase (IDH) 1 or 2 that
Externí odkaz:
https://doaj.org/article/87774fd481ee4919b2a361c6eb91bdf0
Publikováno v:
Tomography, Vol 9, Iss 3, Pp 1062-1070 (2023)
Introduction: Imaging surveillance of contrast-enhancing lesions after the treatment of malignant brain tumors with radiation is plagued by an inability to reliably distinguish between tumor recurrence and treatment effects. Magnetic resonance perfus
Externí odkaz:
https://doaj.org/article/8669f738f5254045b3ae612001990c5c
Autor:
Anuradha G. Trivedi, Su Hyun Kim, Karthik K. Ramesh, Alexander S. Giuffrida, Brent D. Weinberg, Eric A. Mellon, Lawrence R. Kleinberg, Peter B. Barker, Hui Han, Hui-Kuo G. Shu, Hyunsuk Shim, Eduard Schreibmann
Publikováno v:
Tomography, Vol 9, Iss 3, Pp 1052-1061 (2023)
Accurate radiation therapy (RT) targeting is crucial for glioblastoma treatment but may be challenging using clinical imaging alone due to the infiltrative nature of glioblastomas. Precise targeting by whole-brain spectroscopic MRI, which maps tumor
Externí odkaz:
https://doaj.org/article/5e485b96372241f582bdefa0ac6356d7
Autor:
Syed A. Abidi, Michael J. Hoch, Ranliang Hu, Gelareh Sadigh, Alfredo Voloschin, Jeffrey J. Olson, Hui-Kuo G. Shu, Stewart G. Neill, Brent D. Weinberg
Publikováno v:
Tomography, Vol 9, Iss 2, Pp 859-870 (2023)
Multidisciplinary tumor boards (TB) are an essential part of brain tumor care, but quantifying the impact of imaging on patient management is challenging due to treatment complexity and a lack of quantitative outcome measures. This work uses a struct
Externí odkaz:
https://doaj.org/article/55d933f8593f4df1bd3df5362fb5a5e8
Autor:
Karthik K. Ramesh, Vicki Huang, Jeffrey Rosenthal, Eric A. Mellon, Mohammed Goryawala, Peter B. Barker, Saumya S. Gurbani, Anuradha G. Trivedi, Alexander S. Giuffrida, Eduard Schreibmann, Hui Han, Macarena de le Fuente, Erin M. Dunbar, Matthias Holdhoff, Lawrence R. Kleinberg, Hui-Kuo G. Shu, Hyunsuk Shim, Brent D. Weinberg
Publikováno v:
Tomography, Vol 9, Iss 1, Pp 362-374 (2023)
Glioblastoma (GBM) is a fatal disease, with poor prognosis exacerbated by difficulty in assessing tumor extent with imaging. Spectroscopic MRI (sMRI) is a non-contrast imaging technique measuring endogenous metabolite levels of the brain that can ser
Externí odkaz:
https://doaj.org/article/7e1bf384b7a148daa2140d6801c84cdc
Publikováno v:
Radiology Case Reports, Vol 17, Iss 3, Pp 623-627 (2022)
Greater occipital nerve blocks and thermal ablations have been widely discussed as an efficacious treatment strategy for multiple difficult to treat conditions, including occipital neuralgia, migraines, and cervicogenic headaches. Nerve blocks have a
Externí odkaz:
https://doaj.org/article/87efa7b9e73844a5a9b7024b1dd398d2
Autor:
Karen Xu, Karthik Ramesh, Vicki Huang, Saumya S. Gurbani, James Scott Cordova, Eduard Schreibmann, Brent D. Weinberg, Soma Sengupta, Alfredo D. Voloschin, Matthias Holdhoff, Peter B. Barker, Lawrence R. Kleinberg, Jeffrey J. Olson, Hui-Kuo G. Shu, Hyunsuk Shim
Publikováno v:
Tomography, Vol 8, Iss 2, Pp 688-700 (2022)
Glioblastoma (GBM) is highly aggressive and has a poor prognosis. Belinostat is a histone deacetylase inhibitor with blood–brain barrier permeability, anti-GBM activity, and the potential to enhance chemoradiation. The purpose of this clinical tria
Externí odkaz:
https://doaj.org/article/c5d64c1e66924dba9ace3ae3ee5433e3
Autor:
Karthik K. Ramesh, Karen M. Xu, Anuradha G. Trivedi, Vicki Huang, Vahid Khalilzad Sharghi, Lawrence R. Kleinberg, Eric A. Mellon, Hui-Kuo G. Shu, Hyunsuk Shim, Brent D. Weinberg
Publikováno v:
Cancers, Vol 15, Iss 15, p 3956 (2023)
Glioblastoma (GBM) has a poor survival rate even with aggressive surgery, concomitant radiation therapy (RT), and adjuvant chemotherapy. Standard-of-care RT involves irradiating a lower dose to the hyperintense lesion in T2-weighted fluid-attenuated
Externí odkaz:
https://doaj.org/article/aca9332a0a5445f69643065783db7ad4
Autor:
Anuradha G. Trivedi, Karthik K. Ramesh, Vicki Huang, Eric A. Mellon, Peter B. Barker, Lawrence R. Kleinberg, Brent D. Weinberg, Hui-Kuo G. Shu, Hyunsuk Shim
Publikováno v:
Cancers, Vol 15, Iss 13, p 3524 (2023)
Despite aggressive treatment, glioblastoma has a poor prognosis due to its infiltrative nature. Spectroscopic MRI-measured brain metabolites, particularly the choline to N-acetylaspartate ratio (Cho/NAA), better characterizes the extent of tumor infi
Externí odkaz:
https://doaj.org/article/d6f908a72e864f2a914f813d52df29dd