Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Brent D G, Page"'
Autor:
Jing Qian, Yanxia Ma, William M. Tahaney, Cassandra L. Moyer, Amanda Lanier, Jamal Hill, Darian Coleman, Negar Koupaei, Susan G. Hilsenbeck, Michelle I. Savage, Brent D. G. Page, Abhijit Mazumdar, Powel H. Brown
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-16 (2024)
Abstract Background The most aggressive form of breast cancer is triple-negative breast cancer (TNBC), which lacks expression of the estrogen receptor (ER) and progesterone receptor (PR), and does not have overexpression of the human epidermal growth
Externí odkaz:
https://doaj.org/article/c5475652d5314c798be163d273eb4871
Autor:
Jing Qian, Yanxia Ma, William M. Tahaney, Cassandra L. Moyer, Amanda Lanier, Jamal Hill, Darian Coleman, Negar Koupaei, Susan G. Hilsenbeck, Michelle I. Savage, Brent D. G. Page, Abhijit Mazumdar, Powel H. Brown
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/b3912f9d1d094f96a4a647202d931fca
Publikováno v:
ACS Omega, Vol 5, Iss 12, Pp 6872-6887 (2020)
Externí odkaz:
https://doaj.org/article/0b110f14fc6d4f0180b00a1b8ec71aef
Autor:
Jennifer I. Brown, Peng Wang, Alan Y. L. Wong, Boryana Petrova, Rosanne Persaud, Sepideh Soukhtehzari, Melanie Lopez McDonald, Danielle Hanke, Josephine Christensen, Petar Iliev, Weiyuan Wang, Daniel K. Everton, Karla C. Williams, David A. Frank, Naama Kanarek, Brent D. G. Page
Publikováno v:
Metabolites, Vol 13, Iss 2, p 151 (2023)
Dihydrofolate reductase (DHFR) is an established anti-cancer drug target whose inhibition disrupts folate metabolism and STAT3-dependent gene expression. Cycloguanil was proposed as a DHFR inhibitor in the 1950s and is the active metabolite of clinic
Externí odkaz:
https://doaj.org/article/dc113ce5c5ce4058bae4c79c8ea7ac25
Autor:
Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Beato, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
NUDIX hydrolases are an important family of nucleotide-metabolizing enzymes. Here, the authors identify potent, small molecule inhibitors of NUDT5, which is implicated in ADP-ribose and 8-oxo-guanine metabolism, and confirm its role in gene regulatio
Externí odkaz:
https://doaj.org/article/2bf99c4671d44e71969d21873ef164c4
Autor:
Jing Qian, Yanxia Ma, William Tahaney, Cassandra Moyer, Amanda Lanier, Jamal Hill, Darian Coleman, Negar Koupaei, Susan G. Hilsenbeck, Brent D. G. Page, Abhijit Mazumdar, Powel H. Brown
Background: The most aggressive form of breast cancer is triple-negative breast cancer (TNBC) which lacks expression of the estrogen receptor (ER), progesterone receptor (PR), and does not have overexpression of the human epidermal growth factor rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b82758693930a8c6b01c09d0c00d15c9
https://doi.org/10.21203/rs.3.rs-2640186/v1
https://doi.org/10.21203/rs.3.rs-2640186/v1
Autor:
Iryna Kolosenko, Yasmin Yu, Sander Busker, Matheus Dyczynski, Jianping Liu, Martin Haraldsson, Caroline Palm Apergi, Thomas Helleday, Katja Pokrovskaja Tamm, Brent D G Page, Dan Grander
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178844 (2017)
Activation of Signal Transducer and Activator of Transcription 3 (STAT3) has been linked to several processes that are critical for oncogenic transformation, cancer progression, cancer cell proliferation, survival, drug resistance and metastasis. Inh
Externí odkaz:
https://doaj.org/article/3c35e110683a4648b5aa13008599cdad
Publikováno v:
Chembiochem : a European journal of chemical biology. 23(20)
STAT3 protein is a sought-after drug target as it plays a key role in the progression of cancer. Many STAT3 inhibitors (STAT3i) have been reported, but accumulating evidence suggests many of these act as off-target/indirect inhibitors of STAT signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168b4a44d53ffbcc3b12febde4337081
https://pubmed.ncbi.nlm.nih.gov/35698729
https://pubmed.ncbi.nlm.nih.gov/35698729
Autor:
Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Beato, Thomas Helleday
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/8af88760aa3d4c38b6df8ba59624e3f1
Autor:
Annalisa Camporeale, Francesca Marino, Anna Papageorgiou, Paolo Carai, Sara Fornero, Steven Fletcher, Brent D. G. Page, Patrick Gunning, Marco Forni, Roberto Chiarle, Mara Morello, Ole Jensen, Renzo Levi, Stephane Heymans, Valeria Poli
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 4, Pp 572-590 (2013)
Abstract Myocarditis, often triggered by viral infection, may lead to heart auto‐immunity and dilated cardiomyopathy. What determines the switch between disease resolution and progression is however incompletely understood. We show that pharmacolog
Externí odkaz:
https://doaj.org/article/81c6abba30fc42669c6a3e17d5565c87