Výsledky vyhledávání - "Brent C. Welcher"

Ebola virus-like particles protect from lethal Ebola virus infection

Autor: Emily M. Deal, Kelly L. Warfield, M. Javad Aman, Sina Bavari, Mansour Mohamadzadeh, Catharine M. Bosio, Brent C. Welcher, Alan L. Schmaljohn

Publikováno v: Proceedings of the National Academy of Sciences. 100:15889-15894

The filovirus Ebola causes hemorrhagic fever with 70–80% human mortality. High case-fatality rates, as well as known aerosol infectivity, make Ebola virus a potential global health threat and possible biological warfare agent. Development of an eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6e0832e570e8beac2a92c6d6964235
https://doi.org/10.1073/pnas.2237038100

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Lethal Shock Induced by Streptococcal Pyrogenic Exotoxin A in Mice Transgenic for Human Leukocyte Antigen–DQ8 and Human CD4 Receptors: Implications for Development of Vaccines and Therapeutics

Autor: Sina Bavari, Chella S. David, Luis DaSilva, John H. Carra, Juli Hanson, M. Javad Aman, Brent C. Welcher

Publikováno v: The Journal of Infectious Diseases. 186:501-510

Streptococcal and staphylococcal infections result in significant human morbidity and mortality. This study used a transgenic murine model expressing human major histocompatibility complex (MHC) class II and human CD4 in which, without additional tox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c32cf82632d8063b3a8db730c9948df
https://doi.org/10.1086/341828

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Humanlike Immune Response of Human Leukocyte Antigen–DR3 Transgenic Mice to Staphylococcal Enterotoxins: A Novel Model for Superantigen Vaccines

Autor: Brent C. Welcher, Luis DaSilva, M. Javad Aman, Chella S. David, Sina Bavari, Robert G. Ulrich

Publikováno v: The Journal of Infectious Diseases. 185:1754-1760

This study examined the biologic responses of transgenic mice expressing human leukocyte antigen (HLA)-DR3 and human CD4 molecules, in the absence of murine major histocompatibility complex (MHC) class II molecules (Ab(0)), to staphylococcal enteroto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59d6c55bc89a8731e6bdf91a53e1962
https://doi.org/10.1086/340828

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Human leukocyte antigen-DQ8 transgenic mice: a model to examine the toxicity of aerosolized staphylococcal enterotoxin B

Autor: Kelly L. Warfield, Theresa Krakauer, Tom Larsen, Julie Hanson, Chad J. Roy, Sina Bavari, Raoul F. Gonzales, Brent C. Welcher, Chella S. David

Publikováno v: Infection and immunity. 73(4)

Staphylococcal enterotoxins (SEs) belong to a large group of bacterial exotoxins that cause severe immunopathologies, especially when delivered as an aerosol. SEs elicit the release of lethal amounts of cytokines by binding to major histocompatibilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c3e4bf872447feec991bf15f90babd
https://pubmed.ncbi.nlm.nih.gov/15784591

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Mutational effects on protein folding stability and antigenicity: the case of streptococcal pyrogenic exotoxin A

Autor: Brent C. Welcher, John H. Carra, Sina Bavari, Rowena D Schokman, Chella S. David

Publikováno v: Clinical immunology (Orlando, Fla.). 108(1)

The influence of mutationally induced changes in protein folding on development of effective neutralizing antibodies during vaccination remains largely unexplored. In this study, we probed how mutational substitutions of streptococcal pyrogenic exoto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f59d89e9b3ea284d88b9c5390902919
https://pubmed.ncbi.nlm.nih.gov/12865072

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