Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Brent C. Behrens"'
1
SWOG 8825: Melphalan GM-CSF: A phase I study
Autor: Harriet O. Smith, David S. Alberts, James A. Neidhart, Lawrence E. Flaherty, Brent C. Behrens, Elizabeth Poplin, Bruce G. Redman
Publikováno v: Gynecologic Oncology. 44:66-70
The use of intravenous melphalan at higher doses is limited by severe myelosuppression. It was postulated that GM-CSF would permit the use of higher dose melphalan with only moderate myelosuppression easily manageable in an outpatient setting. Theref
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9c3eeb9c752326ce8ae7fc7b1c9c8b
https://doi.org/10.1016/0090-8258(92)90014-a
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2
Phase II Studies of Recombinant Human Tumor Necrosis Factor Alpha in Patients with Malignant Disease: A Summary of the Southwest Oncology Group Experience
Autor: G. T. Budd, Robert P. Whitehead, Barbara Metch, E. David Crawford, Evan M. Hersh, John J. Rinehart, Brent C. Behrens, Franco M. Muggia, Thomas D. Brown, John D. Bonnet
Publikováno v: Journal of Immunotherapy. 10:426-431
From June 1988 to November 1990 the Southwest Oncology Group initiated nine protocols for the phase II evaluation of recombinant human tumor necrosis factor alpha (rhuTNF alpha) in cancer patients. Patients with diverse metastatic malignancies includ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6a7c6c25786b2504889d335c805fc5
https://doi.org/10.1097/00002371-199112000-00006
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3
Phase II trial of interferon-beta-serine in metastatic renal cell carcinoma
Autor: Pierre L. Triozzi, Donn C. Young, Patricia Kinney, Joseph R. Drago, Brent C. Behrens, John J. Rinehart, Henry A. Wise
Publikováno v: Journal of Clinical Oncology. 8:881-885
Interferon-beta-serine (IFN-beta-ser) is a muteine, recombinant IFN that is tolerated at a dose fivefold to 10-fold higher than IFN-alfa and interacts with the same cell membrane receptor as IFN-alfa. We hypothesized that at high doses IFN-beta-ser m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b2b14f787fe889ab8c411e5f502111
https://doi.org/10.1200/jco.1990.8.5.881
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4
Randomized trial of cisplatin and ifosfamide with or without bleomycin in squamous carcinoma of the cervix: a gynecologic oncology group study
Autor: Robert S. Mannel, Anil K. Sood, John A. Blessing, Janet S. Rader, Brent C. Behrens, Maurie Markman, Jo Ann Benda, Jeffrey D. Bloss
Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 20(7)
PURPOSE: Phase II trial reports have suggested that the addition of bleomycin to the combination of cisplatin and ifosfamide may improve response rates and possible survival in squamous carcinoma of the cervix. This study prospectively evaluates the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adf3161b54dd48e23bf63f8582daed4
https://pubmed.ncbi.nlm.nih.gov/11919241
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5
Phase II study of pibenzimol in pancreatic cancer. A Southwest Oncology Group study
Autor: Brent C. Behrens, James A. Neidhart, John S. Macdonald, Eric H. Kraut, Mark Segal, Thomas R. Fleming
Publikováno v: Investigational new drugs. 9(1)
Twenty-three patients with advanced pancreatic adenocarcinoma were treated with Pibenzimol utilizing a daily intravenous schedule for five days. There were no objective responses seen. The major toxicity was pancreatic with grade 3 hyperglycemia in e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5c3ace5c883a891ae1def7991737fb
https://pubmed.ncbi.nlm.nih.gov/1709154
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6
Nitroreduction of 5-nitrofuran derivatives by rat liver xanthine oxidase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase
Autor: Ching Yung Wang, Brent C. Behrens, Masataka Ichikawa, George T. Bryan
Publikováno v: Biochemical Pharmacology. 23:3395-3404
Rat liver cytosol and microsomes catalyzed the nitroreduction of N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide (NFTA), a potent carcinogen for the mouse, rat, hamster and dog, and formed a metabolite capable of binding to protein. The cytosol nitrored
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24af89d74411c463c20262ed1f79c666
https://doi.org/10.1016/0006-2952(74)90342-6
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7
Activity of tricyclic nucleoside 5′-phosphate in model systems of human ovarian cancer
Autor: Takashi Tsuruo, Karen R. Grotzinger, Thomas C. Hamilton, Wilma M. McKoy, Karen G. Louie, Robert F. Ozols, Brent C. Behrens, Robert C. Young
Publikováno v: Investigational New Drugs. 4:295-304
Tricyclic nucleoside 5'-phosphate (TCN-P) was evaluated in two models of human ovarian cancer. TCN-P reduced both colony number and volume in clonogenic assays employing human ovarian cancer cell lines. TCN-P cytotoxicity depended on the concentratio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929e2ea758b2f4511a49b639b216514c
https://doi.org/10.1007/bf00173502
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8
Current Management of Hodgkin??s Disease
Autor: Brent C. Behrens, Robert C. Young, Vincent T. DeVita
Publikováno v: Drugs. 30:355-367
The prognosis of patients with Hodgkin's disease has dramatically improved over the past few decades. Treatment with currently standard radiotherapy or combination chemotherapy programmes will result in durable complete remissions and probable cure i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba9fc1529b25956758a12fd0a03cc3d
https://doi.org/10.2165/00003495-198530040-00004
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10
INDUCTION OF PROGESTERONE RECEPTOR WITH 17β-ESTRADI0L IN HUMAN OVARIAN CANCER
Autor: Thomas C. Hamilton, Brent C. Behrens, Robert F. Ozols, Karen G. Louie
Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 59:561-563
We utilized a xenograft model of human ovarian cancer to study the ability of estrogen to induce progesterone receptor. Tumor cytosol from 17 beta-estradiol treated oophorectomized animals, but not oophorectomized controls, contained a [3H]ORG 2058 b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7702d37f8e662b6791330abda86303af
https://doi.org/10.1210/jcem-59-3-561
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