Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Brent A. French"'
Autor:
Tamara Straub, Julia Nave, Pascal Bouvain, Mohammad Akbarzadeh, Siva Sai Krishna Dasa, Julia Kistner, Zhaoping Ding, Aseel Marzoq, Stefanie Stepanow, Katrin Becker, Julia Hesse, Karl Köhrer, Ulrich Flögel, Mohammad R. Ahmadian, Brent A. French, Jürgen Schrader, Sebastian Temme
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract After myocardial infarction (MI), epicardial cells reactivate their embryonic program, proliferate and migrate into the damaged tissue to differentiate into fibroblasts, endothelial cells and, if adequately stimulated, to cardiomyocytes. Tar
Externí odkaz:
https://doaj.org/article/926c75b0bc764b2880ee83245f14ba59
Publikováno v:
Cardiology Research and Practice, Vol 2020 (2020)
Background. We hypothesized that daily administration of a potent antioxidant (α-lipoic acid: ALA) would protect the heart against both acute myocardial infarction (AMI) and left ventricular remodeling (LVR) post-AMI. Methods and Results. Two separa
Externí odkaz:
https://doaj.org/article/425ce28e7ed34f1bb14799d8e28ec96d
Autor:
Xiucui Ma, Kartik Mani, Haiyan Liu, Attila Kovacs, John T. Murphy, Layla Foroughi, Brent A. French, Carla J. Weinheimer, Aldi Kraja, Ivor J. Benjamin, Joseph A. Hill, Ali Javaheri, Abhinav Diwan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 4 (2019)
Background Mutations in αB‐crystallin result in proteotoxic cardiomyopathy with desmin mislocalization to protein aggregates. Intermittent fasting (IF) is a novel approach to activate transcription factor EB (TFEB), a master regulator of the autop
Externí odkaz:
https://doaj.org/article/ad805593a61c4dcbbca1bbb8a105465c
Autor:
Daniel M. O'Connor, Robert S. Smith, Bryan A. Piras, Ronald J. Beyers, Dan Lin, John A. Hossack, Brent A. French
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 4 (2016)
BackgroundIvabradine selectively inhibits the pacemaker current of the sinoatrial node, slowing heart rate. Few studies have examined the effects of ivabradine on the mechanical properties of the heart after reperfused myocardial infarction (MI). Adv
Externí odkaz:
https://doaj.org/article/4c9f74416deb4b1fb6e06209cae6788f
Autor:
Prasad R. Konkalmatt, Defeng eDeng, Stephanie eThomas, Michael T. Wu, Craig D. Logsdon, Brent A. French, Kimberly A Kelly
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
Pancreatic ductal adenocarcinoma (PDAC) is highly malignant disease that is the 4th leading cause of cancer-related death in the US. Gene therapy using AAV vectors to selectively deliver genes to PDAC cells is an attractive treatment option for pancr
Externí odkaz:
https://doaj.org/article/bc580d6f5e0549c082577fe778c9bea0
Autor:
Soham A. Shah, Claire E. Reagan, Julia E. Bresticker, Abigail G. Wolpe, Miranda E. Good, Edgar H. Macal, Helen O. Billcheck, Leigh A. Bradley, Brent A. French, Brant E. Isakson, Matthew J. Wolf, Frederick H. Epstein
Publikováno v:
JACC: Basic to Translational Science. 8:501-514
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a388786b22f91065b5a3284451adc9b6
https://doi.org/10.1016/j.jacbts.2022.11.005
https://doi.org/10.1016/j.jacbts.2022.11.005
Autor:
Alyssa B. Becker, Lanlin Chen, Bo Ning, Song Hu, John A. Hossack, Alexander L. Klibanov, Brian H. Annex, Brent A. French
Publikováno v:
Ultrasound Med Biol
Mouse models are critical in developing new therapeutic approaches to treat peripheral arterial disease (PAD). Despite decades of research and numerous clinical trials, the efficacy of available therapies is limited. This may suggest shortcomings in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1f3b3217af4bd17ecb41b161a1df08
https://doi.org/10.1016/j.ultrasmedbio.2022.02.002
https://doi.org/10.1016/j.ultrasmedbio.2022.02.002
Autor:
Gang Yu, Susmita Chakrabarti, Miroslava Tischenko, Ai-Lan Chen, Zhijie Wang, Hyosuk Cho, Brent A. French, Sathyamangla V. Naga Prasad, Qiuyun Chen, Qing K. Wang
Publikováno v:
Science translational medicine. 14(648)
Brugada syndrome (BrS) is a fatal arrhythmia that causes an estimated 4% of all sudden death in high-incidence areas. SCN5A encodes cardiac sodium channel Na V 1.5 and causes 25 to 30% of BrS cases. Here, we report generation of a knock-in (KI) mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ebcce9de322e222278be42ef528e26
https://pubmed.ncbi.nlm.nih.gov/35764821
https://pubmed.ncbi.nlm.nih.gov/35764821
Using wastewater surveillance as a continuous pooled sampling technique has been in place in many countries since the early stages of the outbreak of COVID-19. Since the beginning of the outbreak, many research works have emerged, studying different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a1d9040206d6f32757c5faee3f3c67
https://doi.org/10.1101/2021.10.19.21265221
https://doi.org/10.1101/2021.10.19.21265221
Autor:
Xiucui Ma, David R. Rawnsley, Attila Kovacs, Moydul Islam, John T. Murphy, Chen Zhao, Minu Kumari, Layla Foroughi, Haiyan Liu, Kevin Qi, Aaradhya Diwan, Krzysztof Hyrc, Sarah Evans, Takashi Satoh, Brent A. French, Kenneth B. Margulies, Ali Javaheri, Babak Razani, Douglas L. Mann, Kartik Mani, Abhinav Diwan
Publikováno v:
JACC. Basic to translational science. 7(3)
Mitochondria are essential for cardiac myocyte function, but damaged mitochondria trigger cardiac myocyte death. Although mitophagy, a lysosomal degradative pathway to remove damaged mitochondria, is robustly active in cardiac myocytes in the unstres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647130cf8ff3be7b140d9df6c1821861
https://pubmed.ncbi.nlm.nih.gov/35411325
https://pubmed.ncbi.nlm.nih.gov/35411325