Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Brent A. Appleton"'
Autor:
Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik
PDF file - 166K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ad7594fcd5df49250ddfdaff9459d2
https://doi.org/10.1158/1541-7786.22511388
https://doi.org/10.1158/1541-7786.22511388
Autor:
Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik
PDF file - 74K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab586f9613d97b5fef19284a31f81a52
https://doi.org/10.1158/1541-7786.22511394
https://doi.org/10.1158/1541-7786.22511394
Autor:
Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik
PDF file - 28K, Percent Inhibition of MDA-MB-231 or H358 cells when grown as colonies on Scivax plates in the presence of LJI308.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac94484c1d0dc1a9aeed55e1da54f5f1
https://doi.org/10.1158/1541-7786.22511382
https://doi.org/10.1158/1541-7786.22511382
Autor:
Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik
PDF file - 650K, Figure S1. RSK N-terminal Kinase Directly Phosphorylates YB1 on Ser102. COS7 cells either (A) untransfected or (B) transiently expressing WT RSK2 or T493M RSK2 were placed under serum starvation conditions for 20 hrs, followed by 3 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0775c12e2c455a77f0f6170b2bd449e4
https://doi.org/10.1158/1541-7786.22511391
https://doi.org/10.1158/1541-7786.22511391
Autor:
Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik
The p90 ribosomal S6 kinase (RSK) family of serine/threonine kinases is expressed in a variety of cancers and its substrate phosphorylation has been implicated in direct regulation of cell survival, proliferation, and cell polarity. This study charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8ae1dcb5259c892f097fe0a3db0af33
https://doi.org/10.1158/1541-7786.c.6539931.v1
https://doi.org/10.1158/1541-7786.c.6539931.v1
Autor:
Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik
XLSX file - 27K, Competition binding of LJH685, LJI308, BI-D1870-AE, and FMK-PA at 10 microM concentration to either 96 or 492 kinases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c710e99010aa509d4e83e6d2196235f
https://doi.org/10.1158/1541-7786.22511385.v1
https://doi.org/10.1158/1541-7786.22511385.v1
Autor:
Francesco Hofmann, William R. Sellers, Clive McCarthy, Markus Wartmann, Peter Drueckes, Dorothea Haasen, Jutta Blank, Michael D. Jones, John E. Monahan, David A. Ruddy, Emily Buck, Joseph Schoepfer, Sabrina Wagner, Brent A. Appleton, Pascal Furet, Elisa Degenkolbe, Ralph Tiedt
Supplementary Figures 1-2, Tables 1-4, Methods from A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3613711d07dd229641d5f5262ca31848
https://doi.org/10.1158/0008-5472.22388450.v1
https://doi.org/10.1158/0008-5472.22388450.v1
Autor:
Daniel Baird, John H. Brumell, Kirsty Hooper, Leon Murphy, Jonathan M. Goodwin, Jeff Saunders, Sreekanth R. Rouduri, Sravya Kommineni, Archana Jha, Aylwin Ng, Oliver Florey, Menghao Wei, Taoyingnan Li, Mark R. Chance, Ward G. Walkup, Timothy Lehmberg, Sagar R. Budhe, Qing Tang, Jorge Garcia-Fortanet, Yaya Fan, Asmita Agrawal, Katherine Fletcher, Brent A. Appleton, Andrea Ballabio, Chieko Kishi-Itakura, Janna Kiselar
Publikováno v:
Science Advances. 7
Adaptive changes in lysosomal capacity are driven by the transcription factors TFEB and TFE3 in response to increased autophagic flux and endolysosomal stress, yet the molecular details of their activation are unclear. LC3 and GABARAP members of the
Autor:
Sagar R. Budhe, Qing Tang, Timothy Lehmberg, Andrea Ballabio, Katherine Fletcher, Menghao Wei, Asmita Agrawal, Daniel Baird, Sreekanth R. Rouduri, Ward G. Walkup, Oliver Florey, Archana Jha, John H. Brumell, Jorge Garcia-Fortanet, Leon Murphy, Sravya Kommineni, Kirsty Hooper, Jonathan M. Goodwin, Chieko Kishi-Itakura, Brent A. Appleton, Yaya Fan, Aylwin Ng, Janna Kiselar, Jeffrey J. Saunders, Mark R. Chance, Taoyingnan Li
Adaptive changes in lysosomal capacity are driven by the transcription factors TFEB and TFE3 in response to increased autophagic flux and endolysosomal stress, yet the molecular details of their activation are unclear. LC3 and GABARAP members of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::539ee4ceb1fc409289003ea1203b8149
https://doi.org/10.1101/2021.02.22.432209
https://doi.org/10.1101/2021.02.22.432209
Autor:
Colin K. Skepper, Robert J. Moreau, Brent A. Appleton, Bret M. Benton, Joseph E. Drumm, Brian Y. Feng, Mei Geng, Cheng Hu, Cindy Li, Andreas Lingel, Yipin Lu, Mulugeta Mamo, Wosenu Mergo, Mina Mostafavi, Christopher M. Rath, Micah Steffek, Kenneth T. Takeoka, Kyoko Uehara, Lisha Wang, Jun-Rong Wei, Lili Xie, Wenjian Xu, Qiong Zhang, Javier de Vicente
Publikováno v:
Journal of Medicinal Chemistry. 61:3325-3349
In the preceding manuscript [ Moreau et al. 2018 , 10.1021/acs.jmedchem.7b01691 ] we described a successful fragment-based lead discovery (FBLD) strategy for discovery of bacterial phosphopantetheine adenylyltransferase inhibitors (PPAT, CoaD). Follo