Výsledky vyhledávání - "Brent A Dickinson"

A synthetic microRNA-92a inhibitor (MRG-110) accelerates angiogenesis and wound healing in diabetic and nondiabetic wounds

Autor: Aimee L. Jackson, Brent A Dickinson, Corrie L. Gallant-Behm, Christina Dalby, Joseph Piper, Linda A Pestano

Publikováno v: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 26(4)

There is a strong unmet need for new therapeutics to accelerate wound healing across both chronic and acute indications. It is well established that local tissue hypoxia, vascular insufficiency, and/or insufficient angiogenesis contribute to inadequa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadc221330a84deb01b3da639152eb69
https://pubmed.ncbi.nlm.nih.gov/30118158

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Feasibility, distribution, and efficacy of an inhaled oligonucleotide mimic of miR-29 for pulmonary fibrosis induced by bleomycin in rats

Autor: Rusty L. Montgomery, Linda A Pestano, Catherine Nicholas, Guoying Yu, Farida Ahangari, Naftali Kaminski, Jacob D. McDonald, Philip J. Kuehl, Jeremy Brower, Christina Dalby, Jose D. Herazo-Maya, Brent A Dickinson, Corrie L. Gallant-Behm

Publikováno v: Mechanisms of Lung Injury and Repair.

miRNA-29 targets multiple profibrotic molecules and is down-regulated during organ fibrosis, including IPF. Previously, we showed a synthetic, chemically stabilized oligonucleotide mimic of miR-29b could repress collagen expression and abrogate pulmo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ef82326a3ad9bf8b949062a6c3a1331
https://doi.org/10.1183/1393003.congress-2017.pa3480

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Plasma microRNAs serve as biomarkers of therapeutic efficacy and disease progression in hypertension-induced heart failure

Autor: Rusty L. Montgomery, Steven M. Lewton, Brent A Dickinson, Christianna Stack, Anita G. Seto, Hillary M. Semus, Paul Latimer, Thomas G. Hullinger, Joshua M. Lynch, Eva van Rooij

Publikováno v: European Journal of Heart Failure, 15(6), 650-9. Oxford University Press

AIMS: Recent studies have shown that microRNAs (miRNAs), besides being potent regulators of gene expression, can additionally serve as circulating biomarkers of disease. The aim of this study is to determine if plasma miRNAs can be used as indicators

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59fe942d9389bbbf8771aa230f3affc
https://hdl.handle.net/20.500.11755/d7ceac73-e504-42f1-b4a9-80643075dff5

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Phase 1 Study of the Safety and Efficacy of MRG-106, a Synthetic Inhibitor of microRNA-155, in CTCL Patients

Publikováno v: Blood. 130:820-820

Introduction & Objectives: MRG-106 is an oligonucleotide inhibitor of miR-155, a microRNA with a strong mechanistic link to CTCL. The goals of this first-in-human study are to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a51ffe91183cf62256d181ae09c8403e
https://doi.org/10.1182/blood.v130.suppl_1.820.820

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Phase 1 trial evaluating MRG-106, a synthetic inhibitor of microRNA-155, in patients with cutaneous t-cell lymphoma (CTCL)

Autor: Gilad Gordon, Paul Rubin, David M. Rodman, Linda A Pestano, Francine M. Foss, Brent A Dickinson, Anita G. Seto, Basem M. William, Christiane Querfeld, Theresa R. Pacheco, Pierluigi Porcu, Judy Ruckman, Jennifer DeSimone, William Marshall, Aimee L. Jackson, Mark Sanseverino, Youn H. Kim, Michele L Landry, Ahmad Halwani

Publikováno v: Journal of Clinical Oncology. 35:7564-7564

7564 Background: MRG-106 is an oligonucleotide inhibitor of miR-155, a microRNA with a strong mechanistic link to CTCL, selected based on its activity in mycosis fungoides (MF) cell lines. The objective of this first-in-human study is to evaluate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::194bfc9397baa6f7c8ace8213857f85e
https://doi.org/10.1200/jco.2017.35.15_suppl.7564

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MicroRNA-214 antagonism protects against renal fibrosis

Autor: Arin B. Aurora, Ruifang Lu, John D. McClure, Laura Denby, Brent A Dickinson, Jennifer S. Grant, Christian Delles, Eva van Rooij, Andrew H. Baker, David Kipgen, Vasudev Ramdas, Bryan R. Conway

Publikováno v: Journal of the American Society of Nephrology, 25(1), 65-80. American Society of Nephrology

Renal tubulointerstitial fibrosis is the common end point of progressive renal disease. MicroRNA (miR)-214 and miR-21 are upregulated in models of renal injury, but the function of miR-214 in this setting and the effect of its manipulation remain unk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786ab850d88e66a0237f50212de87eed
https://pure.knaw.nl/portal/en/publications/418747d1-2c5a-4d08-9a2d-b2a475a261a9

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Preliminary Results of a Phase 1 Trial Evaluating MRG-106, a Synthetic microRNA Antagonist (LNA antimiR) of microRNA-155, in Patients with CTCL

Autor: Linda A Pestano, Anita G. Seto, Theresa R. Pacheco, William Marshall, Gilad Gordon, Judy Ruckman, Mark Sanseverino, David M. Rodman, Christiane Querfeld, Brent A Dickinson, Francine M. Foss, Aimee L. Jackson, Pierluigi Porcu, Michele L Landry, Ahmad Halwani

Publikováno v: Blood. 128:1829-1829

Introduction and Objectives: microRNAs are small, non-coding RNAs that regulate expression of multiple genes which impact physiological processes and cellular phenotypes. miR-155-5p is a well-described onco-miR with a strong mechanistic link to cutan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c18d56691db26a85ec482da6815ca75
https://doi.org/10.1182/blood.v128.22.1829.1829

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Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha

Autor: Thomas R. Cech, Stacie J. Froelich-Ammon, Steve C. Schultz, Joanne M. Bevilacqua, Brent A. Dickinson

Publikováno v: Genes & Development. 12:1504-1514

Telomeres, the protein–DNA complexes at the termini of eukaryotic chromosomes, are vital for the preservation and complete replication of the genome (for reviews, see Blackburn 1991; Zakian 1995; Greider 1996). The past few years have seen explosiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafb71b22e1e539bd2d20920eb30b281
https://doi.org/10.1101/gad.12.10.1504

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