Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Brent, Wilkinson"'
Autor:
Jianzhi Jiang, Brent Wilkinson, Ilse Flores, Nicolas Hartel, Simeon R. Mihaylov, Veronica A. Clementel, Helen R. Flynn, Fowsan S. Alkuraya, Sila Ultanir, Nicholas A. Graham, Marcelo P. Coba
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
A large number of synaptic proteins have been recurrently associated with complex brain disorders. One of these proteins, the Traf and Nck interacting kinase (TNIK), is a postsynaptic density (PSD) signaling hub, with many variants reported in neurod
Externí odkaz:
https://doaj.org/article/71c2f47483de4fde9adf3e8577e72175
Autor:
Michael J. Hurley, Claudio Urra, B. Maximiliano Garduno, Agostino Bruno, Allison Kimbell, Brent Wilkinson, Cristina Marino-Buslje, Marcelo Ezquer, Fernando Ezquer, Pedro F. Aburto, Elie Poulin, Rodrigo A. Vasquez, Robert Deacon, Ariel Avila, Francisco Altimiras, Peter Whitney Vanderklish, Guido Zampieri, Claudio Angione, Gabriele Constantino, Todd C. Holmes, Marcelo P. Coba, Xiangmin Xu, Patricia Cogram
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
The degu (Octodon degus) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology
Externí odkaz:
https://doaj.org/article/e09a35f5fb5646e3af0bc630bdc8e841
Autor:
Murat Kilinc, Vineet Arora, Thomas K Creson, Camilo Rojas, Aliza A Le, Julie Lauterborn, Brent Wilkinson, Nicolas Hartel, Nicholas Graham, Adrian Reich, Gemma Gou, Yoichi Araki, Àlex Bayés, Marcelo Coba, Gary Lynch, Courtney A Miller, Gavin Rumbaugh
Publikováno v:
eLife, Vol 11 (2022)
Loss-of-function variants in SYNGAP1 cause a developmental encephalopathy defined by cognitive impairment, autistic features, and epilepsy. SYNGAP1 splicing leads to expression of distinct functional protein isoforms. Splicing imparts multiple cellul
Externí odkaz:
https://doaj.org/article/b2d529b24e8e40d98531dc9a6b1666ca
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory g
Externí odkaz:
https://doaj.org/article/fb039a57560646a886a69c1f53f3cebd
Autor:
Marcella Birtele, Ashley Del Dosso, Tiantian Xu, Tuan Nguyen, Brent Wilkinson, Jean-Paul Urenda, Gavin Knight, Roger Moore, Ritin Sharma, Patrick Pirrotte, Randolph S. Ashton, Eric J. Huang, Marcelo P. Coba, Giorgia Quadrato
Autism spectrum disorder (ASD) is a genetically heterogeneous disorder linked with rare, inherited and de novo mutations occurring in two main functional gene categories: gene expression regulation and synaptic function1. Accumulating evidence points
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bab7ddd31ecd5462381bafcc4ee896
https://doi.org/10.21203/rs.3.rs-1610145/v1
https://doi.org/10.21203/rs.3.rs-1610145/v1
Autor:
Murat Kilinc, Vineet Arora, Thomas K Creson, Camilo Rojas, Aliza A Le, Julie Lauterborn, Brent Wilkinson, Nicolas Hartel, Nicholas Graham, Adrian Reich, Gemma Gou, Yoichi Araki, Àlex Bayés, Marcelo Coba, Gary Lynch, Courtney A Miller, Gavin Rumbaugh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2632c3ea572bd76f5bc9d445cec22daf
https://doi.org/10.7554/elife.75707.sa2
https://doi.org/10.7554/elife.75707.sa2
Autor:
Murat Kilinc, Vineet Arora, Thomas K Creson, Camilo Rojas, Aliza A Le, Julie Lauterborn, Brent Wilkinson, Nicolas Hartel, Nicholas Graham, Adrian Reich, Gemma Gou, Yoichi Araki, Àlex Bayés, Marcelo Coba, Gary Lynch, Courtney A Miller, Gavin Rumbaugh
SummaryLoss-of-function variants in SYNAGP1 cause a developmental encephalopathy defined by cognitive impairment, autistic features, and epilepsy. SYNGAP1 splicing leads to expression of distinct functional protein isoforms. Splicing imparts multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb18f076d5c40f09c226078126faafd
https://doi.org/10.1101/2021.12.05.471306
https://doi.org/10.1101/2021.12.05.471306
Autor:
Murat, Kilinc, Vineet, Arora, Thomas K, Creson, Camilo, Rojas, Aliza A, Le, Julie, Lauterborn, Brent, Wilkinson, Nicolas, Hartel, Nicholas, Graham, Adrian, Reich, Gemma, Gou, Yoichi, Araki, Àlex, Bayés, Marcelo, Coba, Gary, Lynch, Courtney A, Miller, Gavin, Rumbaugh
Publikováno v:
eLife. 11
Loss-of-function variants in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5dbee7add81c55648ff7db937942db8
https://pubmed.ncbi.nlm.nih.gov/36285208
https://pubmed.ncbi.nlm.nih.gov/36285208
Autor:
Dongqing Zheng, Oleg V. Evgrafov, Marcelo P. Coba, Brent Wilkinson, Nicholas A. Graham, James A. Knowles, Justin K. Ichida, Nicolas G. Hartel
Publikováno v:
Biological Psychiatry. 85:305-316
Background Disrupted in schizophrenia 1 (DISC1) has been implicated in a number of psychiatric diseases along with neurodevelopmental phenotypes such as the proliferation and differentiation of neural progenitor cells. While there has been significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4ba0c530044ebfd3047afdfc73a98d
https://doi.org/10.1016/j.biopsych.2018.05.009
https://doi.org/10.1016/j.biopsych.2018.05.009
Autor:
Marcelo P. Coba, Brent Wilkinson
Publikováno v:
Cell Signal
The postsynaptic density (PSD) plays an essential role in the organization of the synaptic signaling machinery. It contains a set of core scaffolding proteins that provide the backbone to PSD protein-protein interaction networks (PINs). These core sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5abde4a54a61b4b64f9b9cb5830c60
https://pubmed.ncbi.nlm.nih.gov/32941943
https://pubmed.ncbi.nlm.nih.gov/32941943