Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Brent, Johnston"'
Autor:
Adam Nelson, Nichole McMullen, Simon Gebremeskel, Roberto De Antueno, Duncan Mackenzie, Roy Duncan, Brent Johnston
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-17 (2024)
Abstract Background Metastatic breast cancer is a leading cause of cancer death in woman. Current treatment options are often associated with adverse side effects and poor outcomes, demonstrating the need for effective new treatments. Immunotherapies
Externí odkaz:
https://doaj.org/article/149fda54df0043feaa5581db68f00768
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen capable of exploiting barriers and immune defects to cause chronic lung infections in conditions such as cystic fibrosis. In these contexts, host immune responses are ineffective at
Externí odkaz:
https://doaj.org/article/8b015517b76a4d5f9da338ae995056b0
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/2a11c742814c47859ba424e93861f13a
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Pancreatic cancer is one of the leading causes of cancer death, with a 5-year -year survival rate of less than 10%. This results from late detection, high rates of metastasis, and resistance to standard chemotherapies. Furthermore, chemoth
Externí odkaz:
https://doaj.org/article/ab754f0b3e7843e7ac702d1e8de97a79
Autor:
Simon Gebremeskel, Adam Nelson, Brynn Walker, Tora Oliphant, Lynnea Lobert, Douglas Mahoney, Brent Johnston
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background Oncolytic viruses reduce tumor burden in animal models and have generated promising results in clinical trials. However, it is likely that oncolytic viruses will be more effective when used in combination with other therapies. Current ther
Externí odkaz:
https://doaj.org/article/b3b902b4ff724b35a49d74931c02c94f
Publikováno v:
Cancers, Vol 13, Iss 20, p 5174 (2021)
NKT cells are a specialized subset of lipid-reactive T lymphocytes that play direct and indirect roles in immunosurveillance and anti-tumor immunity. Preclinical studies have shown that NKT cell activation via delivery of exogenous glycolipids elicit
Externí odkaz:
https://doaj.org/article/5d24ad999382496ea412a482cd655f82
Autor:
Brent Johnston, Graham Dellaire, Livia E. Clarke, Tora Oliphant, Brynn Walker, Kaitlyn Tanner, Lynnea Lobert, Simon Gebremeskel
Cell death pathways induced by gemcitabine and mafosfamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2429e8525273a0b17decf1c1a26ab9da
https://doi.org/10.1158/2326-6066.22537828
https://doi.org/10.1158/2326-6066.22537828
Autor:
Brent Johnston, Graham Dellaire, Livia E. Clarke, Tora Oliphant, Brynn Walker, Kaitlyn Tanner, Lynnea Lobert, Simon Gebremeskel
Figure legends for supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce1e515108c7c96e15abd6a4c85f1ec
https://doi.org/10.1158/2326-6066.22537822.v1
https://doi.org/10.1158/2326-6066.22537822.v1
Autor:
Fabrice Le Boeuf, Simon Gebremeskel, Nichole McMullen, Han He, Anna L. Greenshields, David W. Hoskin, John C. Bell, Brent Johnston, Chungen Pan, Roy Duncan
Publikováno v:
Molecular Therapy: Oncolytics, Vol 6, Iss C, Pp 80-89 (2017)
The reovirus fusion-associated small transmembrane (FAST) proteins are the smallest known viral fusogens (∼100–150 amino acids) and efficiently induce cell-cell fusion and syncytium formation in multiple cell types. Syncytium formation enhances c
Externí odkaz:
https://doaj.org/article/3cd936949ec64f11bd4b289f8ff2b5b9
Autor:
Brendan T. McKeown, Nicholas J. Relja, Steven R. Hall, Simon Gebremeskel, Jeanna M. MacLeod, Chansey J. Veinotte, Leah G. Bennett, Leanne B. Ohlund, Lekha Sleno, David L. Jakeman, Jason N. Berman, Brent Johnston, Kerry B. Goralski
Publikováno v:
Canadian journal of physiology and pharmacology.
Despite numerous therapeutic options, multidrug resistance (MDR) remains an obstacle to successful breast cancer therapy. Jadomycin B, a natural product derived from Streptomyces venezuelae ISP5230, maintains cytotoxicity in MDR human breast cancer c