Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brennon O'Callaghan"'
Autor:
Brennon O’Callaghan, Bente Hofstra, Hillary P. Handler, Holly B. Kordasiewicz, Tracy Cole, Lisa Duvick, Jillian Friedrich, Orion Rainwater, Praseuth Yang, Michael Benneyworth, Tessa Nichols-Meade, Wesley Heal, Rachel Ter Haar, Christine Henzler, Harry T. Orr
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 1006-1016 (2020)
Spinocerebellar ataxia type 1 (SCA1) is a lethal, autosomal dominant neurodegenerative disease caused by a polyglutamine expansion in the ATAXIN-1 (ATXN1) protein. Preclinical studies demonstrate the therapeutic efficacy of approaches that target and
Externí odkaz:
https://doaj.org/article/15f7655d7b4b46cf81aff01299a0c211
Autor:
Judit M. Pérez Ortiz, Nissa Mollema, Nicholas Toker, Carolyn J. Adamski, Brennon O'Callaghan, Lisa Duvick, Jillian Friedrich, Michael A. Walters, Jessica Strasser, Jon E. Hawkinson, Huda Y. Zoghbi, Christine Henzler, Harry T. Orr, Sarita Lagalwar
Publikováno v:
Neurobiology of Disease, Vol 116, Iss , Pp 93-105 (2018)
Spinocerebellar ataxia type 1 (SCA1) is a polyglutamine (polyQ) repeat neurodegenerative disease in which a primary site of pathogenesis are cerebellar Purkinje cells. In addition to polyQ expansion of ataxin-1 protein (ATXN1), phosphorylation of ATX
Externí odkaz:
https://doaj.org/article/b9f62c15636b4d38bc9157a6c5c1ed0f
Autor:
Sricharan Bandhakavi, Hongwei Xie, Brennon O'Callaghan, Hiroshi Sakurai, Do-Hyung Kim, Timothy J Griffin
Publikováno v:
PLoS ONE, Vol 3, Iss 2, p e1598 (2008)
TOR kinases integrate environmental and nutritional signals to regulate cell growth in eukaryotic organisms. Here, we describe results from a study combining quantitative proteomics and comparative expression analysis in the budding yeast, S. cerevis
Externí odkaz:
https://doaj.org/article/ebd1db4f63ea48c7ade200fc54d1228f
Autor:
Lisa Duvick, W. Michael Southern, Kellie Benzow, Hillary P. Handler, Jason S. Mitchell, Hannah Kuivinen, Udaya Keerthy Gadiparthi, Praseuth Yang, Alyssa Soles, Carrie Scheeler, Orion Rainwater, Serres Shannah, Erin Larson, Tessa Nichols-Meade, Yun You, Brennon O’Callaghan, Huda Y. Zoghbi, James M. Ervasti, Marija Cvetanovic, Michael D. Koob, Harry T. Orr
Publikováno v:
bioRxiv
Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by an expanded polyglutamine tract in the widely expressed ATXN1 protein. To elucidate anatomical regions and cell types that underlie mutant ATXN1-induced disease pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097ef39977231952db5f84fa6647e9d2
https://europepmc.org/articles/PMC9934664/
https://europepmc.org/articles/PMC9934664/
Autor:
Hillary P. Handler, Lisa Duvick, Jason S. Mitchell, Marija Cvetanovic, Molly Reighard, Alyssa Soles, Kathleen B. Mather, Orion Rainwater, Shannah Serres, Tessa Nichols-Meade, Stephanie L. Coffin, Yun You, Brian L. Ruis, Brennon O’Callaghan, Christine Henzler, Huda Y. Zoghbi, Harry T. Orr
Publikováno v:
Neuron. 111:493-507.e6
Spinocerebellar ataxia type 1 (SCA1) is a dominant trinucleotide repeat neurodegenerative disease characterized by motor dysfunction, cognitive impairment, and premature death. Degeneration of cerebellar Purkinje cells is a frequent and prominent pat
Autor:
Hillary P. Handler, Lisa Duvick, Jason Mitchell, Marija Cvetanovic, Molly Reighard, Alyssa Soles, Orion Rainwater, Shannah Serres, Tessa Nichols-Meade, Stephanie L. Coffin, Yun You, Brian Ruis, Brennon O’Callaghan, Christine Henzler, Huda Y. Zoghbi, Harry T. Orr
SUMMARYSpinocerebellar ataxia type 1 (SCA1) is a dominant trinucleotide repeat neurodegenerative disease characterized by motor dysfunction, cognitive impairment, and premature death. Degeneration of cerebellar Purkinje cells is a frequent and promin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99b0a7086a08ec6f57f5d9f58b01f2e7
https://doi.org/10.1101/2021.12.16.472987
https://doi.org/10.1101/2021.12.16.472987
Publikováno v:
Gene. 145:257-259
The nucleotide sequence of a cloned satellite DNA from Antilocapra americana (American pronghorn antelope) is presented. The 1477-bp satellite is composed of degenerate 31-bp sub-repeats which are very similar in sequence to those of the major satell