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Comparison of the effects of lisinopril and a prolyl 4-hydroxylase inhibitor (FG041) on left ventricular function after acute myocardial infarction

Autor: Nwogu, John I., Bean, Maurice, Geenen, David L., Bagai, Jay, De, Ajanta, Reed, Beth E., Nafissi, Mehdi, Brenner, Mitchell, Buttrick, Peter M.

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Stimulation of HIF-1α, HIF-2α, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells

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Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.

Autor: Xingnan Zheng¹, Bo Zhai², Koivunen, Peppi³, Shin, Sandra J.⁴, Gang Lu⁵, Jiayun Liu⁵, Geisen, Christoph⁵, Chakraborty, Abhishek A.⁵, Moslehi, Javid J.⁵, Smalley, David M.⁶, Xin Wei⁷, Xian Chen⁷, Zhengming Chen⁸, Beres, Justine M.¹, Jing Zhang¹, Jen Lan Tsao⁹, Brenner, Mitchell C.⁹, Yuqing Zhang⁴, Cheng Fan¹, DePinho, Ronald A.¹⁰

Publikováno v: Genes & Development. Jul2014, Vol. 28 Issue 13, p10-10. 1p.

Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.

Autor: Li D; Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN-90014, Oulu, Finland., Hirsilä M, Koivunen P, Brenner MC, Xu L, Yang C, Kivirikko KI, Myllyharju J

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2004 Dec 31; Vol. 279 (53), pp. 55051-9. Date of Electronic Publication: 2004 Oct 12.