Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Brennan PE"'
Autor:
Johanssen, T, Wren, SP, Woffindale, C, Priestley, R, De Cesco, S, Ehebauer, MT, Dixon-Clarke, S, Katsouri, L, England, K, Bennet, JM, Fedorov, O, Brennan, PE, Di Daniel, E, Davis, JB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::f7c75c41f7d4cbf97933d57f7502c585
https://ora.ox.ac.uk/objects/uuid:7929f64e-a44b-4de8-a6e6-e44c894cb045
https://ora.ox.ac.uk/objects/uuid:7929f64e-a44b-4de8-a6e6-e44c894cb045
Autor:
Le Bihan, Y-V, Lanigan, RM, Atrash, B, McLaughlin, MG, Velupillai, S, Malcolm, AG, England, KS, Ruda, GF, Mok, NY, Tumber, A, Tomlin, K, Saville, H, Shehu, E, McAndrew, C, Carmichael, L, Bennett, JM, Jeganathan, F, Eve, P, Donovan, A, Hayes, A, Wood, F, Raynaud, FI, Fedorov, O, Brennan, PE, Burke, R, Van Montfort, RLM, Rossanese, OW, Blagg, J, Bavetsias, V
Publikováno v:
European Journal of Medicinal Chemistry
Le Bihan, Y-V, Lanigan, R M, Atrash, B, McLaughlin, M G, Velupillai, S, Malcolm, A G, England, K S, Ruda, G F, Mok, N Y, Tumber, A, Tomlin, K, Saville, H, Shehu, E, McAndrew, C, Carmichael, L, Bennett, J M, Jeganathan, F, Eve, P, Donovan, A, Hayes, A, Wood, F, Raynaud, F I, Fedorov, O, Brennan, P, Burke, R, van Montfort, R L M, Rossanese, O W, Blagg, J & Bavetsias, V 2019, ' C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays ', European Journal of Medicinal Chemistry, vol. 177, pp. 316-337 . https://doi.org/10.1016/j.ejmech.2019.05.041
Le Bihan, Y-V, Lanigan, R M, Atrash, B, McLaughlin, M G, Velupillai, S, Malcolm, A G, England, K S, Ruda, G F, Mok, N Y, Tumber, A, Tomlin, K, Saville, H, Shehu, E, McAndrew, C, Carmichael, L, Bennett, J M, Jeganathan, F, Eve, P, Donovan, A, Hayes, A, Wood, F, Raynaud, F I, Fedorov, O, Brennan, P, Burke, R, van Montfort, R L M, Rossanese, O W, Blagg, J & Bavetsias, V 2019, ' C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays ', European Journal of Medicinal Chemistry, vol. 177, pp. 316-337 . https://doi.org/10.1016/j.ejmech.2019.05.041
Residues in the histone substrate binding sites that differ between the KDM4 and KDM5 subfamilies were identified. Subsequently, a C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one series was designed to rationally exploit these residue differences bet
Autor:
Carvalho, D, Taylor, KR, Olaciregui, NG, Molinari, V, Clarke, M, Mackay, A, Ruddle, R, Henley, A, Valenti, M, Hayes, A, Brandon, ADH, Eccles, SA, Raynaud, F, Boudhar, A, Monje, M, Popov, S, Moore, AS, Mora, J, Cruz, O, Vinci, M, Brennan, PE, Bullock, AN, Carcaboso, AM, Jones, C
Publikováno v:
Communications Biology
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Communications Biology, Vol 2, Iss 1, Pp 1-10 (2019)
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Communications Biology, Vol 2, Iss 1, Pp 1-10 (2019)
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
Diffuse intrinsic pontine glioma (DIPG) is a lethal childhood brainstem tumour, with a quarter of patients harbouring somatic mutations in ACVR1, encoding the serine/threonine kinase ALK2. Despite being an amenable drug target, little has been done t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7537cf4decd8e8aea8ddd7d009f50ee8
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16288
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16288
Publikováno v:
Mathematics, Vol 12, Iss 6, p 925 (2024)
This study introduces a novel particle model for biomass fast pyrolysis, incorporating an anisotropic cylindrical particle to address mass and energy transport coupled with aerosol ejection, which previous models have overlooked. The main contributio
Externí odkaz:
https://doaj.org/article/f85bdd4238f34b8684bad23ec8421cf7
Autor:
Meier, JC, Tallant, C, Fedorov, O, Witwicka, H, Hwang, SY, van Stiphout, RG, Lambert, JP, Rogers, C, Yapp, C, Gerstenberger, BS, Fedele, V, Savitsky, P, Heidenreich, D, Daniels, DL, Owen, DR, Fish, PV, Igoe, NM, Bayle, ED, Haendler, B, Oppermann, UCT, Buffa, F, Brennan, PE, Müller, S, Gingras, AC, Odgren, PR, Birnbaum, MJ, Knapp, S
Publikováno v:
ACS Chemical Biology
Histone acetyltransferases of the MYST family are recruited to chromatin by BRPF scaffolding proteins. We explored functional consequences and the therapeutic potential of inhibitors targeting acetyl-lysine dependent protein interaction domains (brom
In the last five years, the development of inhibitors of bromodomains has emerged as an area of intensive worldwide research. Emerging evidence has implicated a number of non-BET bromodomains in the onset and progression of diseases such as cancer, H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1182ef495f1facfe19b1286e962e68d2
https://ora.ox.ac.uk/objects/uuid:956a586d-603f-43df-af67-0eec13d94d0a
https://ora.ox.ac.uk/objects/uuid:956a586d-603f-43df-af67-0eec13d94d0a
Autor:
Fedorov, O, Lingard, H, Wells, C, Monteiro, OP, Picaud, S, Keates, T, Yapp, C, Philpott, M, Martin, SJ, Felletar, I, Marsden, BD, Filippakopoulos, P, Müller, S, Knapp, S, Brennan, PE
Publikováno v:
Journal of Medicinal Chemistry
Bromodomains are gaining increasing interest as drug targets. Commercially sourced and de novo synthesized substituted [1,2,4]triazolo[4,3-a]phthalazines are potent inhibitors of both the BET bromodomains such as BRD4 as well as bromodomains outside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::743d9b400d3d2c4d25a3a009d369870a
https://doi.org/10.1021/jm401568s
https://doi.org/10.1021/jm401568s
Autor:
Picaud, S, Wells, C, Felletar, I, Brotherton, D, Martin, S, Savitsky, P, Philpott, M, Bountra, C, Lingard, H, Fedorov, O, Müller, S, Brennan, PE, Knapp, S, Filippakopoulos, P, Diez-Dacal, B
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(49)
Bromodomains have emerged as attractive candidates for the development of inhibitors targeting gene transcription. Inhibitors of the bromo and extraterminal (BET) family recently showed promising activity in diverse disease models. However, the pleio
Autor:
Marco Antonio Ardila-Barragán, Ph. D. (c), Carlos Francisco Valdés-Rentería, Ph. D., Brennan Pecha, Ph. D., Alfonso López-Díaz, Ph. D., Eduardo Gil-Lancheros, M.Sc., Marley Cecilia Vanegas-Chamorro, Ph. D., Jesús Emilio Camporredondo-Saucedo, Ph. D., Luis Fernando Lozano-Gómez, M.Sc.
Publikováno v:
Revista Facultad de Ingeniería, Vol 28, Iss 53, Pp 53-77 (2019)
Gasification studies were performed on sub-bituminous coal of the province Centro in Boyacá state of Colombia, vegetable biomass Chenopodium album (cenizo) and co-gasification of coal-biomass mixtures agglomerated with paraffin in a thermogravimetri
Externí odkaz:
https://doaj.org/article/a176a29317db4258a1d2a548f2a7c399
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