Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Brennan Murphy"'
Publikováno v:
Molecules, Vol 22, Iss 10, p 1669 (2017)
Skeletal muscle is a major insulin-target tissue and plays an important role in glucose homeostasis. Impaired insulin action in muscles leads to insulin resistance and type 2 diabetes mellitus. 5′ AMP-activated kinase (AMPK) is an energy sensor, it
Externí odkaz:
https://doaj.org/article/9e949df417b44942b55eca61879be73d
Autor:
Veronica F. Busa, Barbara S. Slusher, Morgan Dasovich, Jürgen Bosch, Aravinth Kumar Jayabalan, Jack Wei, Ajit G. Thomas, Karli R Redinger, Takashi Tsukamoto, Shang-Jung Cheng, Brennan Murphy, Jack A Goodman, Robert Lyle McPherson, Anthony K.L. Leung, Junlin Zhuo
Macrodomains are a class of conserved ADP-ribosylhydrolases expressed by viruses of pandemic concern, including coronaviruses and alphaviruses. Viral macrodomains are critical for replication and virus-induced pathogenesis; therefore, these enzymes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d858df342bafdd113eb438d9f0eb438
https://doi.org/10.1101/2021.10.07.463234
https://doi.org/10.1101/2021.10.07.463234
Autor:
Atanas D. Radkov, Brennan Murphy, Edward Hall, Yves V. Brun, Caitlyn Mulcahey, Garrett Booher, Jacob Yablonowski, Michael S. VanNieuwenhze, Felipe Cava, Laura Alvarez, Erkin Kuru, Yen-Pang Hsu
Publikováno v:
Nature chemistry
Peptidoglycan (PG) is an essential cell wall component that maintains the morphology and viability of nearly all bacteria. Its biosynthesis requires periplasmic transpeptidation reactions which construct peptide cross-linkages between polysaccharide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61ddafb2a7ff303a66c6d2f86a85b5d
http://europepmc.org/articles/PMC6444347
http://europepmc.org/articles/PMC6444347
Autor:
Yifan Zhang, Daniel J. Raines, Hongwei Wu, Chuchu Guo, Elizabeth M. Nolan, Michael S. VanNieuwenhze, Brennan Murphy, Anne-K. Duhme-Klair, Katherine A. Edmonds, David P. Giedroc
Publikováno v:
Prof. Nolan via Ye Li
Streptococcus pneumoniae (Spn) is an important Gram-positive human pathogen that causes millions of infections worldwide with an increasing occurrence of antibiotic resistance. Fe acquisition is a crucial virulence determinant in Spn; further, Spn re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd51d084fe5cb25b514b87a0a31ec80
https://hdl.handle.net/1721.1/128018
https://hdl.handle.net/1721.1/128018
Publikováno v:
Organic Letters. 19:1156-1159
The hydroxylated cyclohexenone carboxylic acid moiety of xylosmin was synthesized in eight steps from benzoic acid. The key steps in the synthesis involved the enzymatic dihydroxylation of benzoic acid by the whole cell fermentation with Ralstonia eu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0160881458525183daa60538a568dce6
https://doi.org/10.1021/acs.orglett.7b00194
https://doi.org/10.1021/acs.orglett.7b00194
Publikováno v:
Organic letters. 21(7)
Lantibiotics are a class of peptide antibiotics with activity against most Gram-positive bacteria. Lanthionine (Lan) and β-MeLan are unusual thioether-bridged, non-proteinogenic amino acids, which are characteristic features of lantibiotics. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db7387205d296bf72a08a77150f84ec
https://pubmed.ncbi.nlm.nih.gov/30855974
https://pubmed.ncbi.nlm.nih.gov/30855974
Publikováno v:
Angewandte Chemie (International ed. in English). 57(34)
Advanced intermediates for the syntheses of tetrodotoxin reported by the groups of Fukuyama, Alonso, and Sato were prepared. Key steps include the toluene dioxygenase mediated dihydroxylation of either iodobenzene or benzyl acetate. The resulting die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8094da6bd4c365871f9359ee91246ff
https://pubmed.ncbi.nlm.nih.gov/29750851
https://pubmed.ncbi.nlm.nih.gov/29750851
Autor:
Mary Ann A. Endoma-Arias, D. Phillip Cox, Brennan Murphy, Ivan Šnajdr, Ales Machara, Tomáš Hudlický, Theocharis C. Stamatatos
Publikováno v:
Advanced Synthesis & Catalysis. 356:2679-2687
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a13e8b0d9099f2183c0bbc0894d1be2e
https://doi.org/10.1002/adsc.201400445
https://doi.org/10.1002/adsc.201400445
Publikováno v:
Clinical and experimental pharmacologyphysiology. 44(1)
Compounds that increase the activity of the energy sensor AMP-activated kinase (AMPK) have the potential to regulate blood glucose levels. Although rosemary extract (RE) has been reported to activate AMPK and reduce blood glucose levels in vivo, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1d82f3a537d2df8670cdc0ed01a6dc
https://pubmed.ncbi.nlm.nih.gov/27716981
https://pubmed.ncbi.nlm.nih.gov/27716981
Publikováno v:
Angewandte Chemie International Edition. 57:11079-11079
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27879546f05d4538adbb880e0ae1adf1
https://doi.org/10.1002/anie.201806823
https://doi.org/10.1002/anie.201806823