Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Brennan K. Smith"'
Autor:
Bo Wang, Evangelia E. Tsakiridis, Shuman Zhang, Andrea Llanos, Eric M. Desjardins, Julian M. Yabut, Alexander E. Green, Emily A. Day, Brennan K. Smith, James S. V. Lally, Jianhan Wu, Amogelang R. Raphenya, Krishna A. Srinivasan, Andrew G. McArthur, Shingo Kajimura, Jagdish Suresh Patel, Michael G. Wade, Katherine M. Morrison, Alison C. Holloway, Gregory R. Steinberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Chlorpyrifos is a widely-used pesticide and a common residue on vegetables and fruits. Here the authors show that at non-neurotoxic doses, chlorpyrifos reduces energy expenditure, by inhibiting diet induced thermogenesis, and promotes obesity and ins
Externí odkaz:
https://doaj.org/article/17efe75eaf7346188e0d2025067371da
Autor:
Arun Bhaskar, Alan Bell, Michael Boivin, Wellington Briques, Matthew Brown, Hance Clarke, Claude Cyr, Elon Eisenberg, Ricardo Ferreira de Oliveira Silva, Eva Frohlich, Peter Georgius, Malcolm Hogg, Tina Ingrid Horsted, Caroline A. MacCallum, Kirsten R. Müller-Vahl, Colleen O’Connell, Robert Sealey, Marc Seibolt, Aaron Sihota, Brennan K. Smith, Dustin Sulak, Antonio Vigano, Dwight E. Moulin
Publikováno v:
Journal of Cannabis Research, Vol 3, Iss 1, Pp 1-12 (2021)
Abstract Background Globally, medical cannabis legalization has increased in recent years and medical cannabis is commonly used to treat chronic pain. However, there are few randomized control trials studying medical cannabis indicating expert guidan
Externí odkaz:
https://doaj.org/article/0b02aa14e0ff414db8032de89f403549
Autor:
Emily A. Day, Rebecca J. Ford, Brennan K. Smith, Vanessa P. Houde, Stephanie Stypa, Sonia Rehal, Sarka Lhotak, Bruce E. Kemp, Bernardo L. Trigatti, Geoff H. Werstuck, Richard C. Austin, Morgan D. Fullerton, Gregory R. Steinberg
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101321- (2021)
Objective: Salsalate is a prodrug of salicylate that lowers blood glucose in people with type 2 diabetes. AMP-activated protein kinase (AMPK) is an αβγ heterotrimer which inhibits macrophage inflammation and the synthesis of fatty acids and choles
Externí odkaz:
https://doaj.org/article/ac41af7c053648d78768cda15dc2b35a
Autor:
Ryan M. Esquejo, Christopher T. Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K. Smith, Emily A. Day, Chuong Nguyen, Kieran F. Geoghegan, John M. Kreeger, Alan Opsahl, Jessica Ward, Amit S. Kalgutkar, David Tess, Lynne Butler, Norimitsu Shirai, Timothy F. Osborne, Gregory R. Steinberg, Morris J. Birnbaum, Kimberly O. Cameron, Russell A. Miller
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 122-132 (2018)
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-A
Externí odkaz:
https://doaj.org/article/3a6b1a8ecd964eee8550aafb2b27ef05
Autor:
Denis Choquette, Jonathan Chan, Mohammad Bardi, Carolyn Whiskin, Gabriel Torani, Brennan K. Smith, Aaron Sihota
Publikováno v:
Pharmacy Practice, Vol 19, Iss 3, p 2377 (2021)
Background: Recent approvals for novel agents such as the small molecule Janus kinase inhibitors (JAKi), combined with the advent of biosimilars has widened the gamut of available therapeutic options in the treatment of rheumatoid arthritis (RA). Thi
Externí odkaz:
https://doaj.org/article/b06dff93a722404299da840680bc5778
Autor:
Kristen E. Boyle, Zachary W. Patinkin, Allison L.B. Shapiro, Carly Bader, Lauren Vanderlinden, Katerina Kechris, Rachel C. Janssen, Rebecca J. Ford, Brennan K. Smith, Gregory R. Steinberg, Elizabeth J. Davidson, Ivana V. Yang, Dana Dabelea, Jacob E. Friedman
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1503-1516 (2017)
Objective: Infants born to mothers with obesity have greater adiposity, ectopic fat storage, and are at increased risk for childhood obesity and metabolic disease compared with infants of normal weight mothers, though the cellular mechanisms mediatin
Externí odkaz:
https://doaj.org/article/c956e384a84b44429f534a27385f457e
Autor:
Stephen L. Pinkosky, Roger S. Newton, Emily A. Day, Rebecca J. Ford, Sarka Lhotak, Richard C. Austin, Carolyn M. Birch, Brennan K. Smith, Sergey Filippov, Pieter H.E. Groot, Gregory R. Steinberg, Narendra D. Lalwani
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Statins are lipid-lowering drugs that prevent cardiovascular disease but tolerability is limited by severe side effects in muscles. Here the authors elucidate a liver-specific activation mechanism for bempedoic acid, a novel cholesterol-lowering drug
Externí odkaz:
https://doaj.org/article/1f66c328c6054aecb4400856a6c02de9
Autor:
Linda A. Villani, Brennan K. Smith, Katarina Marcinko, Rebecca J. Ford, Lindsay A. Broadfield, Alex E. Green, Vanessa P. Houde, Paola Muti, Theodoros Tsakiridis, Gregory R. Steinberg
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 1048-1056 (2016)
Objective: The sodium-glucose transporter 2 (SGLT2) inhibitors Canagliflozin and Dapagliflozin are recently approved medications for type 2 diabetes. Recent studies indicate that SGLT2 inhibitors may inhibit the growth of some cancer cells but the me
Externí odkaz:
https://doaj.org/article/b9f92a22e002499f9a6381410683e0c8
Autor:
Katarina Marcinko, Adam L. Bujak, James S.V. Lally, Rebecca J. Ford, Tammy H. Wong, Brennan K. Smith, Bruce E. Kemp, Yonchu Jenkins, Wei Li, Todd M. Kinsella, Yasumichi Hitoshi, Gregory R. Steinberg
Publikováno v:
Molecular Metabolism, Vol 4, Iss 9, Pp 643-651 (2015)
Objective: Skeletal muscle AMP-activated protein kinase (AMPK) is important for regulating glucose homeostasis, mitochondrial content and exercise capacity. R419 is a mitochondrial complex-I inhibitor that has recently been shown to acutely activate
Externí odkaz:
https://doaj.org/article/8ea255508c3c42c6b55c6482ed5223f4
Autor:
Eric M. Desjardins, Brennan K. Smith, Emily A. Day, Serge Ducommun, Matthew J. Sanders, Joshua P. Nederveen, Rebecca J. Ford, Stephen L. Pinkosky, Logan K. Townsend, Robert M. Gutgesell, Rachel Lu, Kei Sakamoto, Gregory R. Steinberg
Publikováno v:
Desjardins, E M, Smith, B K, Day, E A, Ducommun, S, Sanders, M J, Nederveen, J P, Ford, R J, Pinkosky, S L, Townsend, L K, Gutgesell, R M, Lu, R, Sakamoto, K & Steinberg, G R 2022, ' The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 48, e2119824119 . https://doi.org/10.1073/pnas.2119824119
Fatty acids are vital for the survival of eukaryotes, but when present in excess can have deleterious consequences. The AMP-activated protein kinase (AMPK) is an important regulator of multiple branches of metabolism. Studies in purified enzyme prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ff00af91b3737ddb124470677dad36
https://pubmed.ncbi.nlm.nih.gov/36409897
https://pubmed.ncbi.nlm.nih.gov/36409897