Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Brennan C. McEwan"'
Autor:
Jason S. Wasserman, Bulat Faezov, Kishan R. Patel, Alison M. Kurimchak, Seren M. Palacio, David J. Glass, Holly Fowle, Brennan C. McEwan, Qifang Xu, Ziran Zhao, Lauren Cressey, Neil Johnson, James S. Duncan, Arminja N. Kettenbach, Roland L. Dunbrack, Xavier Graña
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The Ser/Thr protein phosphatase 2 A (PP2A) regulates the dephosphorylation of many phosphoproteins. Substrate recognition are mediated by B regulatory subunits. Here, we report the identification of a substrate conserved motif [RK]-V-x-x-[VI
Externí odkaz:
https://doaj.org/article/6e9017a5c5d34b82817862a82164f6a6
Autor:
Holly Fowle, Ziran Zhao, Qifang Xu, Jason S Wasserman, Xinru Wang, Mary Adeyemi, Felicity Feiser, Alison N Kurimchak, Diba Atar, Brennan C McEwan, Arminja N Kettenbach, Rebecca Page, Wolfgang Peti, Roland L Dunbrack, Xavier Graña
Publikováno v:
eLife, Vol 10 (2021)
Protein phosphorylation is a reversible post-translation modification essential in cell signaling. This study addresses a long-standing question as to how the most abundant serine/threonine protein phosphatase 2 (PP2A) holoenzyme, PP2A/B55α, specifi
Externí odkaz:
https://doaj.org/article/6761c6a9c42749159283c5b22082407f
Autor:
S Zachary Swartz, Hieu T Nguyen, Brennan C McEwan, Mark E Adamo, Iain M Cheeseman, Arminja N Kettenbach
Publikováno v:
eLife, Vol 10 (2021)
Meiosis is a specialized cell cycle that requires sequential changes to the cell division machinery to facilitate changing functions. To define the mechanisms that enable the oocyte-to-embryo transition, we performed time-course proteomics in synchro
Externí odkaz:
https://doaj.org/article/f633bbf5007145098af78b2bf58abe6b
Autor:
Gianmatteo Vit, Joana Duro, Girish Rajendraprasad, Emil P T Hertz, Lya Katrine Kauffeldt Holland, Melanie Bianca Weisser, Brennan C McEwan, Blanca Lopez‐Mendez, Paula Sotelo‐Parrilla, A Arockia Jeyaprakash, Guillermo Montoya, Niels Mailand, Kenji Maeda, Arminja Kettenbach, Marin Barisic, Jakob Nilsson
Publikováno v:
Vit, G, Duro, J, Rajendraprasad, G, Hertz, E P T, Holland, L K K, Weisser, M B, McEwan, B C, Lopez-Mendez, B, Sotelo-Parrilla, P, Jeyaprakash, A A, Montoya, G, Mailand, N, Maeda, K, Kettenbach, A, Barisic, M & Nilsson, J 2022, ' Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061 ', EMBO Journal, vol. 41, no. 14, e110611 . https://doi.org/10.15252/embj.2022110611
Protein phosphatase 2A (PP2A) is an abundant phosphoprotein phosphatase that acts as a tumor suppressor. For this reason, compounds able to activate PP2A are attractive anticancer agents. The compounds iHAP1 and DT-061 have recently been reported to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17bdcd227aeee9bfe729ad771c85b7dc
https://doi.org/10.15252/embj.2022110611
https://doi.org/10.15252/embj.2022110611
Autor:
Alison N Kurimchak, Rebecca Page, Brennan C McEwan, Arminja N. Kettenbach, Wolfgang Peti, Holly Fowle, Xavier Graña, Qifang Xu, Jason S. Wasserman, Xinru Wang, Ziran Zhao, Roland L. Dunbrack, Diba Atar, Mary Adeyemi, Felicity Feiser
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Protein phosphorylation is a reversible post-translation modification essential in cell signaling. This study addresses a long-standing question as to how the most abundant serine/threonine protein phosphatase 2 (PP2A) holoenzyme, PP2A/B55α, specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3ec302472311e87c32e0b164ec9980
https://doi.org/10.7554/elife.63181
https://doi.org/10.7554/elife.63181
Autor:
Alison N Kurimchak, Rebecca Page, Jason S. Wasserman, Holly Fowle, Arminja N. Kettenbach, Felicity Feiser, Xavier Graña, Wolfgang Peti, Xinru Wang, Diba Atar, Qifang Xu, Roland L. Dunbrack, Brennan C McEwan, Mary Adeyemi, Ziran Zhao
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6e0cc5ebe4ae4229a838aedcf3ca4e0
https://doi.org/10.7554/elife.63181.sa2
https://doi.org/10.7554/elife.63181.sa2
Autor:
Mark E. Adamo, Iain M. Cheeseman, Arminja N. Kettenbach, Brennan C McEwan, S. Zachary Swartz, Hieu T Nguyen
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Meiosis is a specialized cell cycle that requires sequential changes to the cell division machinery to facilitate changing functions. To define the mechanisms that enable the oocyte-to-embryo transition, we performed time-course proteomics in synchro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e98d10f3863e0ddccd5c7dad17bb16
http://europepmc.org/articles/PMC8370769
http://europepmc.org/articles/PMC8370769
Autor:
Brennan C McEwan, Marin Barisic, Gianmatteo Vit, Blanca López-Méndez, Kenji Maeda, Jakob Nilsson, Guillermo Montoya, Arminja N. Kettenbach, Lya Katrine Kauffeldt Holland, Niels Mailand, Emil Peter Thrane Hertz, Girish Rajendraprasad, Joana Duro, Melanie Bianca Weisser
PP2A is an abundant phosphoprotein phosphatase that acts as a tumor suppressor. For this reason, compounds able to activate PP2A are attractive anticancer agents. The small molecule compounds iHAP1 and DT-061 have recently been reported by Leonard et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::451c3956bfc6131e63300f7ccff8637b
https://doi.org/10.1101/2021.07.08.451586
https://doi.org/10.1101/2021.07.08.451586
Autor:
S. Zachary Swartz, Brennan C McEwan, Iain M. Cheeseman, Arminja N. Kettenbach, Hieu T Nguyen, Mark E. Adamo
Meiosis is a specialized cell cycle that requires sequential changes to the cell division machinery to facilitate changing functions. To define the mechanisms that enable the oocyte-to-embryo transition, we performed time-course proteomics in sea sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4e80e800fbf6ac710eb4c236f616597
https://doi.org/10.1101/2020.08.21.260216
https://doi.org/10.1101/2020.08.21.260216