Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Brenna M Henn"'
Autor:
Oshiomah P Oyageshio, Justin W Myrick, Jamie Saayman, Lena van der Westhuizen, Dana R Al-Hindi, Austin W Reynolds, Noah Zaitlen, Eileen G Hoal, Caitlin Uren, Marlo Möller, Brenna M Henn
Publikováno v:
PLOS Global Public Health, Vol 4, Iss 7, p e0002643 (2024)
South Africa is among the world's top eight tuberculosis (TB) burden countries, and despite a focus on HIV-TB co-infection, most of the population living with TB are not HIV co-infected. The disease is endemic across the country, with 80-90% exposure
Externí odkaz:
https://doaj.org/article/f3c07423a3cf4bc49bb6904f085684b3
Autor:
Kimberly F McManus, Angela M Taravella, Brenna M Henn, Carlos D Bustamante, Martin Sikora, Omar E Cornejo
Publikováno v:
PLoS Genetics, Vol 13, Iss 3, p e1006560 (2017)
The human DARC (Duffy antigen receptor for chemokines) gene encodes a membrane-bound chemokine receptor crucial for the infection of red blood cells by Plasmodium vivax, a major causative agent of malaria. Of the three major allelic classes segregati
Externí odkaz:
https://doaj.org/article/a8019be581f548d5ba90a9f82a765938
Autor:
Caitlin Uren, Brenna M Henn, Andre Franke, Michael Wittig, Paul D van Helden, Eileen G Hoal, Marlo Möller
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174738 (2017)
Utilizing data from published tuberculosis (TB) genome-wide association studies (GWAS), we use a bioinformatics pipeline to detect all polymorphisms in linkage disequilibrium (LD) with variants previously implicated in TB disease susceptibility. The
Externí odkaz:
https://doaj.org/article/40591fd29e34426b8e16a2d2b0827a42
Autor:
Hugo G Hilton, Paul J Norman, Neda Nemat-Gorgani, Ana Goyos, Jill A Hollenbach, Brenna M Henn, Christopher R Gignoux, Lisbeth A Guethlein, Peter Parham
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005439 (2015)
Modulating natural killer cell functions in human immunity and reproduction are diverse interactions between the killer cell immunoglobulin-like receptors (KIR) of Natural Killer (NK) cells and HLA class I ligands on the surface of tissue cells. Domi
Externí odkaz:
https://doaj.org/article/48d329440aa04ca99896e97fb5f0f631
Autor:
Alicia R Martin, Helio A Costa, Tuuli Lappalainen, Brenna M Henn, Jeffrey M Kidd, Muh-Ching Yee, Fabian Grubert, Howard M Cann, Michael Snyder, Stephen B Montgomery, Carlos D Bustamante
Publikováno v:
PLoS Genetics, Vol 10, Iss 8, p e1004549 (2014)
Large-scale sequencing efforts have documented extensive genetic variation within the human genome. However, our understanding of the origins, global distribution, and functional consequences of this variation is far from complete. While regulatory v
Externí odkaz:
https://doaj.org/article/034634dd18804c91bad00abc6cb5c6c2
Autor:
Martin Sikora, Meredith L Carpenter, Andres Moreno-Estrada, Brenna M Henn, Peter A Underhill, Federico Sánchez-Quinto, Ilenia Zara, Maristella Pitzalis, Carlo Sidore, Fabio Busonero, Andrea Maschio, Andrea Angius, Chris Jones, Javier Mendoza-Revilla, Georgi Nekhrizov, Diana Dimitrova, Nikola Theodossiev, Timothy T Harkins, Andreas Keller, Frank Maixner, Albert Zink, Goncalo Abecasis, Serena Sanna, Francesco Cucca, Carlos D Bustamante
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004353 (2014)
Genome sequencing of the 5,300-year-old mummy of the Tyrolean Iceman, found in 1991 on a glacier near the border of Italy and Austria, has yielded new insights into his origin and relationship to modern European populations. A key finding of that stu
Externí odkaz:
https://doaj.org/article/b5bbf105664b4daf83ea8d4ab7feb9bc
Autor:
Michelle Daya, Lize van der Merwe, Ushma Galal, Marlo Möller, Muneeb Salie, Emile R Chimusa, Joshua M Galanter, Paul D van Helden, Brenna M Henn, Chris R Gignoux, Eileen Hoal
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82224 (2013)
Admixture is a well known confounder in genetic association studies. If genome-wide data is not available, as would be the case for candidate gene studies, ancestry informative markers (AIMs) are required in order to adjust for admixture. The predomi
Externí odkaz:
https://doaj.org/article/f67a454426964a82b186f80ce36b0e1e
Autor:
Emile R Chimusa, Michelle Daya, Marlo Möller, Raj Ramesar, Brenna M Henn, Paul D van Helden, Nicola J Mulder, Eileen G Hoal
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73971 (2013)
Admixed populations can make an important contribution to the discovery of disease susceptibility genes if the parental populations exhibit substantial variation in susceptibility. Admixture mapping has been used successfully, but is not designed to
Externí odkaz:
https://doaj.org/article/151d690633a348dd9b3bed133a6f68ec
Autor:
Brenna M Henn, Laura R Botigué, Simon Gravel, Wei Wang, Abra Brisbin, Jake K Byrnes, Karima Fadhlaoui-Zid, Pierre A Zalloua, Andres Moreno-Estrada, Jaume Bertranpetit, Carlos D Bustamante, David Comas
Publikováno v:
PLoS Genetics, Vol 8, Iss 1, p e1002397 (2012)
North African populations are distinct from sub-Saharan Africans based on cultural, linguistic, and phenotypic attributes; however, the time and the extent of genetic divergence between populations north and south of the Sahara remain poorly understo
Externí odkaz:
https://doaj.org/article/e868eb557dc94e459cf112cf9d7b8405
Autor:
Brenna M Henn, Lawrence Hon, J Michael Macpherson, Nick Eriksson, Serge Saxonov, Itsik Pe'er, Joanna L Mountain
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34267 (2012)
Although a few hundred single nucleotide polymorphisms (SNPs) suffice to infer close familial relationships, high density genome-wide SNP data make possible the inference of more distant relationships such as 2(nd) to 9(th) cousinships. In order to c
Externí odkaz:
https://doaj.org/article/bbdd4fac64fa49518bb5186fde30fd42