Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis

Autor: Brenig, R, Pop, OT, Triantafyllou, E, Geng, A, Singanayagam, A, Perez-Shibayama, C, Besse, L, Cupovic, J, Kuenzler, P, Boldanova, T, Brand, S, Semela, D, Duong, FHT, Weston, CJ, Ludewig, B, Heim, MH, Wendon, J, Antoniades, CG, Bernsmeier, C

Publikováno v: Life Science Alliance

Immune dysfunction determines morbidity and mortality in liver cirrhosis. Distinct AXL-expressing circulating monocytes, which regulate antimicrobial responses, expand with progression of the disease.
Infectious complications in patients with ci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::44943e8645de8544194cdaf558b41c48
http://europepmc.org/articles/PMC6907389

CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure

Autor: Bernsmeier, C, Triantafyllou, E, Brenig, R, Lebosse, F, Singanayagam, A, Patel, V, Pop, O, Khamri, W, Nathwani, R, Tidswell, R, Weston, C, Adams, D, Thursz, M, Wendon, J, Antoniades, C

OBJECTIVE: Immune paresis in patients with acute-on-chronic liver failure (ACLF) accounts for infection susceptibility and increased mortality. Immunosuppressive mononuclear CD14+HLA-DR- myeloid-derived suppressor cells (M-MDSCs) have recently been i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c0fba1ac82f67a71d24a2064904db34e

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

CD14 ⁺ CD15 ^- HLA-DR ^- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure.

Autor: Bernsmeier C; Institute of Liver Studies, King's College Hospital, King's College London, London, UK.; Liver Biology Laboratory, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Triantafyllou E; Institute of Liver Studies, King's College Hospital, King's College London, London, UK.; Division of Digestive Diseases, St. Mary's Campus, Imperial College London, London, UK.; Institute of Immunology and Immunotherapy, NIHR Biomedical Research Unit, Centre for Liver Research, University of Birmingham, Birmingham, UK., Brenig R; Liver Biology Laboratory, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Lebosse FJ; Division of Digestive Diseases, St. Mary's Campus, Imperial College London, London, UK., Singanayagam A; Institute of Liver Studies, King's College Hospital, King's College London, London, UK.; Division of Digestive Diseases, St. Mary's Campus, Imperial College London, London, UK.; Institute of Immunology and Immunotherapy, NIHR Biomedical Research Unit, Centre for Liver Research, University of Birmingham, Birmingham, UK., Patel VC; Institute of Liver Studies, King's College Hospital, King's College London, London, UK., Pop OT; Institute of Liver Studies, King's College Hospital, King's College London, London, UK., Khamri W; Division of Digestive Diseases, St. Mary's Campus, Imperial College London, London, UK., Nathwani R; Division of Digestive Diseases, St. Mary's Campus, Imperial College London, London, UK., Tidswell R; Institute of Liver Studies, King's College Hospital, King's College London, London, UK., Weston CJ; Institute of Immunology and Immunotherapy, NIHR Biomedical Research Unit, Centre for Liver Research, University of Birmingham, Birmingham, UK., Adams DH; Institute of Immunology and Immunotherapy, NIHR Biomedical Research Unit, Centre for Liver Research, University of Birmingham, Birmingham, UK., Thursz MR; Division of Digestive Diseases, St. Mary's Campus, Imperial College London, London, UK., Wendon JA; Institute of Liver Studies, King's College Hospital, King's College London, London, UK., Antoniades CG; Institute of Liver Studies, King's College Hospital, King's College London, London, UK.; Division of Digestive Diseases, St. Mary's Campus, Imperial College London, London, UK.; Institute of Immunology and Immunotherapy, NIHR Biomedical Research Unit, Centre for Liver Research, University of Birmingham, Birmingham, UK.

Publikováno v: Gut [Gut] 2018 Jun; Vol. 67 (6), pp. 1155-1167. Date of Electronic Publication: 2017 Jun 07.