Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Brendy E.W.M. van den Akker"'
Autor:
Daniel Baumhoer, Judith V.M.G. Bovée, Arjen H.G. Cleven, Suk Wai Lam, Dilara C. Savci-Heijink, Sheena L.M. Ong, Anne-Marie Cleton-Jansen, Herman M. Kroon, Brendy E.W.M. van den Akker, Inge H. Briaire-de Bruijn, Karoly Szuhai
Publikováno v:
American Journal of Surgical Pathology, 45(12), 1669-1681. LIPPINCOTT WILLIAMS & WILKINS
A simple bone cyst (SBC) is a cystic bone lesion predominantly affecting young males. The cyst is lined by a fibrous membrane and filled with serosanguinous fluid. EWSR1/FUS-NFATC2 rearrangements were recently identified in SBC. We here report exactl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0541c96baaad602270d348ce83331d65
https://hdl.handle.net/1887/3249798
https://hdl.handle.net/1887/3249798
Autor:
Anne-Marie Cleton-Jansen, Bertine Niessen, Jan Oosting, Ieva Palubeckaitė, Inge H. Briaire-de Bruijn, Natasja Franceschini, Alwine B. Kruisselbrink, Maud Tamsma, Judith V.M.G. Bovée, Brendy E.W.M. van den Akker
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 12
International Journal of Molecular Sciences, 22(12). MDPI
International Journal of Molecular Sciences, Vol 22, Iss 6273, p 6273 (2021)
Volume 22
Issue 12
International Journal of Molecular Sciences, 22(12). MDPI
International Journal of Molecular Sciences, Vol 22, Iss 6273, p 6273 (2021)
For osteosarcoma (OS), the most common primary malignant bone tumor, overall survival has hardly improved over the last four decades. Especially for metastatic OS, novel therapeutic targets are urgently needed. A hallmark of cancer is aberrant metabo
Autor:
Renske D.M. Steenbergen, Renée X. de Menezes, Wim Vos, Maaike C G Bleeker, Taylor Saunders-Wood, Jossie Rotman, Heather Griffin, John Doorbar, Gemma G. Kenter, Sanne Samuels, Maryam Khelil, Ke Zheng, Brendy E.W.M. van den Akker, Ekaterina S. Jordanova
Publikováno v:
Cancer Research, 81(7), 1909-1921. American Association for Cancer Research Inc.
Khelil, M, Griffin, H, Bleeker, M C G, Steenbergen, R D M, Zheng, K, Saunders-Wood, T, Samuels, S, Rotman, J, Vos, W, van den Akker, B E, de Menezes, R X, Kenter, G G, Doorbar, J & Jordanova, E S 2021, ' Delta-like ligand-notch1 signaling is selectively modulated by HPV16 e6 to promote squamous cell proliferation and correlates with cervical cancer prognosis ', Cancer Research, vol. 81, no. 7, pp. 1909-1921 . https://doi.org/10.1158/0008-5472.CAN-20-1996
Khelil, M, Griffin, H, Bleeker, M C G, Steenbergen, R D M, Zheng, K, Saunders-Wood, T, Samuels, S, Rotman, J, Vos, W, van den Akker, B E, de Menezes, R X, Kenter, G G, Doorbar, J & Jordanova, E S 2021, ' Delta-like ligand-notch1 signaling is selectively modulated by HPV16 e6 to promote squamous cell proliferation and correlates with cervical cancer prognosis ', Cancer Research, vol. 81, no. 7, pp. 1909-1921 . https://doi.org/10.1158/0008-5472.CAN-20-1996
Human papillomavirus (HPV) drives high-grade intraepithelial neoplasia and cancer; for unknown reasons, this occurs most often in the cervical transformation zone. Either mutation or HPV E6–driven inhibition of Notch1 can drive neoplastic developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ed5b452bf07faa2097cb26fd0475d5
https://research.vumc.nl/en/publications/6217b3f2-ec90-4073-9dbe-b428ae4d07dd
https://research.vumc.nl/en/publications/6217b3f2-ec90-4073-9dbe-b428ae4d07dd
Autor:
Hans Gelderblom, Augustinus D.G. Krol, Brendy E.W.M. van den Akker, Judith V.M.G. Bovée, Sanne Venneker, Inge H. Briaire-de Bruijn, Ieva Palubeckaitė
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in Molecular Biosciences, 7. FRONTIERS MEDIA SA
Frontiers in Molecular Biosciences, 7. Frontiers Media {SA}
Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in Molecular Biosciences, 7. FRONTIERS MEDIA SA
Frontiers in Molecular Biosciences, 7. Frontiers Media {SA}
Purpose: Chondrosarcomas are a group of cartilaginous malignant neoplasms characterized by the deposition of chondrogenic extracellular matrix. Surgical resection is currently the only curative treatment option, due to their high resistance to conven
Autor:
Connie M. van Rhijn, Jaap F. Hamming, Brendy E.W.M. van den Akker, Laura E. Bruijn, J H N Lindeman
Publikováno v:
Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 9(23). WILEY
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Human mesenchymal cells are culprit factors in vascular (patho)physiology and are hallmarked by phenotypic and functional heterogeneity. At present, they are subdivided by classic umbrella terms, such as “fibroblasts,” “myofibroblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6495cb844711547d52607a2fd78b51
https://doi.org/10.1161/jaha.120.017094
https://doi.org/10.1161/jaha.120.017094
Autor:
Morgane Monchanin, David Monderer, Aurélie Dutour, Emeline Brandinelli, Brendy E.W.M. van den Akker, Yvonne de Jong, Judith V.M.G. Bovée, Jolieke G. van Oosterwijk, Jean-Yves Blay
Publikováno v:
Oncogenesis
Oncogenesis, Vol 7, Iss 9, Pp 1-9 (2018)
Oncogenesis, 7
Oncogenesis, Vol 7, Iss 9, Pp 1-9 (2018)
Oncogenesis, 7
Chondrosarcomas are malignant cartilage tumors showing relative resistance to conventional chemo- and radiotherapy. Previous studies showed that chondrosarcoma cells could be sensitized to chemotherapy by inhibiting the Bcl-2 family members Bcl-2, Bc
Autor:
Brendy E.W.M. van den Akker, Remco J. Molenaar, Elisabeth F.P. Peterse, Ruben D. Addie, Yvonne de Jong, Anne-Marie Cleton-Jansen, Judith V.M.G. Bovée, Bertine Niessen, Alwine B. Kruisselbrink, Arjen H.G. Cleven
Publikováno v:
British Journal of Cancer, 118(8), 1074-1083
British Journal of Cancer
British journal of cancer, 118(8), 1074-1083. Nature Publishing Group
British Journal of Cancer
British journal of cancer, 118(8), 1074-1083. Nature Publishing Group
Introduction: Chondrosarcoma is a malignant cartilage-forming bone tumour in which mutations in IDH1 and IDH2 frequently occur. Previous studies suggest an increased dependency on glutaminolysis in IDH1/2 mutant cells, which resulted in clinical tria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756c4845d002924f05a65af4399301a3
https://hdl.handle.net/1887/79889
https://hdl.handle.net/1887/79889
Autor:
Judith V.M.G. Bovée, Elisabeth F.P. Peterse, Jan Oosting, Erik H.J. Danen, Bertine Niessen, Johnny Suijker, Brendy E.W.M. van den Akker, Anne-Marie Cleton-Jansen, Yvonne de Jong
Publikováno v:
Molecular Cancer Research
Molecular Cancer Research, 15(12), 1714-1721
Molecular Cancer Research, 15(12), 1714-1721
Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyltransferase (NAPRT) are rate-limiting enzymes in the NAD+ synthesis pathway. Chondrosarcoma is a malignant cartilage forming bone tumor, in which mutations altering isoci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7561fbf24fc719c5228f25f219a18df
https://doi.org/10.1158/1541-7786.mcr-17-0293
https://doi.org/10.1158/1541-7786.mcr-17-0293
Autor:
Daniela I. Paiva-Oliveira, Inge H. Briaire-de-Bruijn, Willem E. Corver, Célia Gomes, Anne-Marie Cleton-Jansen, Brendy E.W.M. van den Akker, Judith V.M.G. Bovée, Sara R. Martins-Neves
Publikováno v:
Journal of Cellular Physiology. 231:876-886
Osteosarcoma is a bone tumor, displaying significant cellular and histological heterogeneity and a complex genetic phenotype. Although multiple studies strongly suggest the presence of cancer stem cells in osteosarcoma, a consensus on their character
Autor:
Anne M.L. Jansen, Frederik J. Hes, Marina Ventayol Garcia, Stijn Crobach, Dina Ruano, Brendy E.W.M. van den Akker, Carli M. J. Tops, Tom van Wezel, Juul T. Wijnen, Hans Morreau, Willemina R. R. Geurts-Giele, Winand N.M. Dinjens, Maartje Nielsen
Publikováno v:
Gastroenterology, 152(3), 546
Gastroenterology, 152(3), 546-+. W.B. Saunders
Gastroenterology, 152(3), 546-+. W.B. Saunders
We investigated the presence and patterns of mosaicism in the APC gene in patients with colon neoplasms not associated with any other genetic variants; we performed deep sequence analysis of APC in at least 2 adenomas or carcinomas per patient. We id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051f0874001a5fc7990d4c97b2768144
https://hdl.handle.net/1887/116005
https://hdl.handle.net/1887/116005