Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Brendon P, Scicluna"'
Autor:
Hedwig D. Vrijmoeth, Jeanine Ursinus, Javier Botey-Bataller, Yunus Kuijpers, Xiaojing Chu, Freek R. van de Schoor, Brendon P. Scicluna, Cheng-Jian Xu, Mihai G. Netea, Bart Jan Kullberg, Cees C. van den Wijngaard, Yang Li, Joppe W. Hovius, Leo A. B. Joosten
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Genetic variation underly inter-individual variation in host immune responses to infectious diseases, and may affect susceptibility or the course of signs and symptoms. Methods We performed genome-wide association studies in a pro
Externí odkaz:
https://doaj.org/article/023b3359336f429c8886cecd6f302253
Autor:
Na Li, Junhui Zhu, Peiru Chen, Chuntong Bao, Jun Wang, Tamim Abdelaal, Dexi Chen, Sibo Zhu, Wenjing Wang, Jiangnan Mao, Brendon P. Scicluna, Frits Koning, Fengyang Li, Liancheng Lei
Publikováno v:
Veterinary Research, Vol 54, Iss 1, Pp 1-16 (2023)
Abstract Due to the increase in bacterial resistance, improving the anti-infectious immunity of the host is rapidly becoming a new strategy for the prevention and treatment of bacterial pneumonia. However, the specific lung immune responses and key i
Externí odkaz:
https://doaj.org/article/6d1b909ac931471a81e659654dea8472
Autor:
Erik H. A. Michels, Joe M. Butler, Tom D. Y. Reijnders, Olaf L. Cremer, Brendon P. Scicluna, Fabrice Uhel, Hessel Peters-Sengers, Marcus J. Schultz, Julian C. Knight, Lonneke A. van Vught, Tom van der Poll, MARS consortium
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-16 (2022)
Abstract Background The association of ageing with increased sepsis mortality is well established. Nonetheless, current investigations on the influence of age on host response aberrations are largely limited to plasma cytokine levels while neglecting
Externí odkaz:
https://doaj.org/article/78bc222ac0f646a5975cbe847cad3a1c
Autor:
Alex R. Schuurman, Joe M. Butler, Erik H.A. Michels, Natasja A. Otto, Xanthe Brands, Bastiaan W. Haak, Fabrice Uhel, Augustijn M. Klarenbeek, Daniël R. Faber, Bauke V. Schomakers, Michel van Weeghel, Alex F. de Vos, Brendon P. Scicluna, Riekelt H. Houtkooper, W. Joost Wiersinga, Tom van der Poll
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107181- (2023)
Summary: Neutrophils are potent immune cells with key antimicrobial functions. Previous in vitro work has shown that neutrophil effector functions are mainly fueled by intracellular glycolysis. Little is known about the state of neutrophils still in
Externí odkaz:
https://doaj.org/article/4e949718e4164c9fb99adf50b5dffd0d
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and severe disease characterized by excessive matrix deposition in the lungs. Macrophages play crucial roles in maintaining lung homeostasis but are also central in the
Externí odkaz:
https://doaj.org/article/c5b7c0e436bb4f81b2d2c86b9d92d80e
Autor:
Eleni Karakike, Brendon P. Scicluna, Maria Roumpoutsou, Ioannis Mitrou, Niki Karampela, Athanasios Karageorgos, Konstantinos Psaroulis, Eleni Massa, Achillefs Pitsoulis, Panagiotis Chaloulis, Evanthia Pappa, Irene T. Schrijver, Frantzeska Frantzeskaki, Malvina Lada, Nicolas Dauby, David De Bels, Ioannis Floros, Souzana Anisoglou, Eleni Antoniadou, Maria Patrani, Glykeria Vlachogianni, Eleni Mouloudi, Anastasia Antoniadou, David Grimaldi, Thierry Roger, W. Joost Wiersinga, Iraklis Tsangaris, Evangelos J. Giamarellos-Bourboulis
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-11 (2022)
Abstract Background Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, clinical evidence remains inconclusive. We aimed to evaluate whether clarithromycin improves 28-day mortality amo
Externí odkaz:
https://doaj.org/article/3fb6358b3e844d6284ce50b1283067ca
Autor:
Cansu Tekin, Brendon P. Scicluna, Sophie C. Lodestijn, Kun Shi, Maarten F. Bijlsma, C. Arnold Spek
Publikováno v:
Molecular Oncology, Vol 15, Iss 11, Pp 3091-3108 (2021)
Pancreatic acinar cells have high plasticity and can transdifferentiate into ductal‐like cells. This acinar‐to‐ductal metaplasia (ADM) contributes to tissue maintenance but may also contribute to the premalignant transformation that can eventua
Externí odkaz:
https://doaj.org/article/655bec2113474b9fb2695cc8e9d4dd14
Autor:
Liza Pereverzeva, Fabrice Uhel, Hessel Peters Sengers, Olaf L. Cremer, Marcus J. Schultz, Marc M. J. Bonten, Brendon P. Scicluna, Tom van der Poll, the MARS consortium
Publikováno v:
Annals of Intensive Care, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Background A delay in admission to the intensive care unit (ICU) of patients with community-acquired pneumonia (CAP) has been associated with an increased mortality. Decisions regarding interventions and eligibility for immune modulatory the
Externí odkaz:
https://doaj.org/article/3aa0b177ae904a869f4dc6f353e991b8
Autor:
Xanthe Brands, Bastiaan W. Haak, Augustijn M. Klarenbeek, Joe Butler, Fabrice Uhel, Wanhai Qin, Natasja A. Otto, Marja E. Jakobs, Daniël R. Faber, René Lutter, W. Joost Wiersinga, Tom van der Poll, Brendon P. Scicluna
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background The plasticity of monocytes enables them to exert multiple roles during an immune response, including promoting immune tolerance. How monocytes alter their functions to convey immune tolerance in the context of lower respiratory t
Externí odkaz:
https://doaj.org/article/b06b9c428497488dbd62d7b688aaab55
Autor:
Robert F.J. Kullberg, Xanthe Brands, Augustijn M. Klarenbeek, Joe M. Butler, Natasja A. Otto, Daniël R. Faber, Brendon P. Scicluna, Tom van der Poll, W. Joost Wiersinga, Bastiaan W. Haak
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104740- (2022)
Summary: Human studies describing the immunomodulatory role of the intestinal microbiota in systemic infections are lacking. Here, we sought to relate microbiota profiles from 115 patients with community-acquired pneumonia (CAP), both on hospital adm
Externí odkaz:
https://doaj.org/article/66433c03a1ff48519f96542990b54e96