Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Brendon M Baker"'
Autor:
Hiba Kobeissi, Javiera Jilberto, M Çağatay Karakan, Xining Gao, Samuel J DePalma, Shoshana L Das, Lani Quach, Jonathan Urquia, Brendon M Baker, Christopher S Chen, David Nordsletten, Emma Lejeune
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0298863 (2024)
Advancing human induced pluripotent stem cell derived cardiomyocyte (hiPSC-CM) technology will lead to significant progress ranging from disease modeling, to drug discovery, to regenerative tissue engineering. Yet, alongside these potential opportuni
Externí odkaz:
https://doaj.org/article/b74873e42d354457bd949569e3768cc8
Autor:
Somnath Maji, Mitra Aliabouzar, Carole Quesada, Anjali Chiravuri, Aidan Macpherson, Abigail Pinch, Karsyn Kazyak, Ziyad Emara, Bachir A. Abeid, Robert N. Kent, III, Firaol S. Midekssa, Man Zhang, Brendon M. Baker, Renny T. Franceschi, Mario L. Fabiilli
Publikováno v:
Bioactive Materials, Vol 43, Iss , Pp 82-97 (2025)
Hydrogels can improve the delivery of mesenchymal stromal cells (MSCs) by providing crucial biophysical cues that mimic the extracellular matrix. The differentiation of MSCs is dependent on biophysical cues like stiffness and viscoelasticity, yet con
Externí odkaz:
https://doaj.org/article/81b099d5ebfa4d7aa354f8695d4cdc63
Autor:
Su-Jin Heo, Tristan P Driscoll, Stephen D Thorpe, Nandan L Nerurkar, Brendon M Baker, Michael T Yang, Christopher S Chen, David A Lee, Robert L Mauck
Publikováno v:
eLife, Vol 5 (2016)
Mesenchymal stem cell (MSC) differentiation is mediated by soluble and physical cues. In this study, we investigated differentiation-induced transformations in MSC cellular and nuclear biophysical properties and queried their role in mechanosensation
Externí odkaz:
https://doaj.org/article/16c1483368c14410ae3abebcf88a3596
Autor:
Yao-Chang Tsan, Samuel J. DePalma, Yan-Ting Zhao, Adela Capilnasiu, Yu-Wei Wu, Brynn Elder, Isabella Panse, Kathryn Ufford, Daniel L. Matera, Sabrina Friedline, Thomas S. O’Leary, Nadab Wubshet, Kenneth K. Y. Ho, Michael J. Previs, David Nordsletten, Lori L. Isom, Brendon M. Baker, Allen P. Liu, Adam S. Helms
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Investigations of human cardiac disease involving human pluripotent stem cell-derived cardiomyocytes are limited by the disorganized presentation of biomechanical cues resulting in cell immaturity. Here the authors develop a platform of micron-scale
Externí odkaz:
https://doaj.org/article/866175855d3a4449bdab9d5e10355c8b
Publikováno v:
Advanced Science, Vol 9, Iss 12, Pp n/a-n/a (2022)
Abstract While matrix stiffness regulates cell behavior on 2D substrates, recent studies using synthetic hydrogels have suggested that in 3D environments, cell behavior is primarily impacted by matrix degradability, independent of stiffness. However,
Externí odkaz:
https://doaj.org/article/ac0c6db7d0a8492aacbebcfbc5217a55
Autor:
Xiaotian Tan, Kathleen C. Day, Xuzhou Li, Luke J. Broses, Wen Xue, Weishu Wu, William Y. Wang, Ting-Wen Lo, Emma Purcell, Sicong Wang, Yun-Lu Sun, Maung Kyaw Khaing Oo, Brendon M. Baker, Sunitha Nagrath, Mark L. Day, Xudong Fan
Publikováno v:
Biosensors and Bioelectronics: X, Vol 8, Iss , Pp 100066- (2021)
The functional membrane proteins on tumor-cell-derived EVs contain a large amount of biomolecular information, and can serve as a comprehensive marker to delineate the molecular nature of cancer. However, due to low secretion rates, it is difficult t
Externí odkaz:
https://doaj.org/article/f0e5c940854b43aa825d015c3ef79244
Autor:
Harrison L. Hiraki, Daniel L. Matera, William Y. Wang, Eashan S. Prabhu, Zane Zhang, Firaol Midekssa, Anna E. Argento, Johanna M. Buschhaus, Brock A. Humphries, Gary D. Luker, Abdon Pena-Francesch, Brendon M. Baker
Publikováno v:
Acta Biomater
The peritumoral stroma is a complex 3D tissue that provides cells with myriad biophysical and biochemical cues. Histologic observations suggest that during metastatic spread of carcinomas, these cues influence transformed epithelial cells, prompting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556b964b47464276f557c022132b16d3
https://doi.org/10.1016/j.actbio.2022.09.043
https://doi.org/10.1016/j.actbio.2022.09.043
Autor:
Harrison L. Hiraki, Daniel L. Matera, Michael J. Rose, Robert N. Kent, Connor W. Todd, Mark E. Stout, Anya E. Wank, Maria C. Schiavone, Samuel J. DePalma, Alexander A. Zarouk, Brendon M. Baker
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Fibrous extracellular matrix (ECM) proteins provide mechanical structure and adhesive scaffolding to resident cells within stromal tissues. Aligned ECM fibers play an important role in directing morphogenetic processes, supporting mechanical loads, a
Externí odkaz:
https://doaj.org/article/8f526b155672443fa8b16674f3a0a638
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
How cells migrate in fibrous tissues is still poorly understood. Here, with synthetic 3D fibre matrices of controlled alignment and stiffness, the authors report that cells in stiff matrices move slowly and continuously, but in softer, deformable mat
Externí odkaz:
https://doaj.org/article/b6d65b2bec4e4f619c3788aad89acbbf
Autor:
Mitra Aliabouzar, Oliver D. Kripfgans, William Y. Wang, Brendon M. Baker, J. Brian Fowlkes, Mario L. Fabiilli
Publikováno v:
Ultrasonics Sonochemistry, Vol 72, Iss , Pp 105430- (2021)
Acoustically-responsive scaffolds (ARSs), which are fibrin hydrogels containing monodispersed perfluorocarbon (PFC) emulsions, respond to ultrasound in an on-demand, spatiotemporally-controlled manner via a mechanism termed acoustic droplet vaporizat
Externí odkaz:
https://doaj.org/article/08029374d5ea4d98be29c2fe3779cded