Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Brendon Frank"'
Autor:
Cris Kamperschroer, Brendon Frank, Caroline Genell, Hervé Lebrec, Shermaine Mitchell-Ryan, Brigitte Molinier, Courtni Newsome, Marie-Soleil Piche, Daniel Weinstock, Mark Collinge, Wendy Freebern, Daniel Rubio
Publikováno v:
Journal of Immunotoxicology, Vol 20, Iss 1 (2023)
AbstractCytotoxic T-lymphocytes (CTL) are a subset of T-cells that play a critical role in protecting against intracellular infections and cancer, and have the ability to identify and kill infected or transformed cells expressing non-self peptides as
Externí odkaz:
https://doaj.org/article/e52be90ce9a64f71b5de2941c8e295cf
Publikováno v:
Journal of Immunotoxicology, Vol 18, Iss 1, Pp 154-162 (2021)
The immunotoxic potential of drug candidates is assessed through the examination of results from a variety of in vitro and in vivo immunophenotyping and functional study endpoints in pre-clinical studies. CD8+ cytotoxic T-lymphocyte (CTL) activity im
Externí odkaz:
https://doaj.org/article/e0ce9dcc7d614ab5b9780e895fd53896
Autor:
Brendon Frank, Yu-Ling Wei, Kyung-Hoon Kim, Abraham Guerrero, Hervé Lebrec, Mercedesz Balazs, Xiaoting Wang
Publikováno v:
Journal of Immunotoxicology, Vol 15, Iss 1, Pp 119-125 (2018)
The immunotoxic potential of drug candidates is assessed through the examination of results from a variety of studies and endpoints. While the functional assessment of CD8+ cytotoxic T-lymphocytes (CTL) is well-characterized in the clinic, the lack o
Externí odkaz:
https://doaj.org/article/0d61cdca2da642319ce676710d9aa3e1
Autor:
Karen Rex, Shawn Jeffries, Matthew L Brown, Timothy Carlson, Angela Coxon, Flordeliza Fajardo, Brendon Frank, Darin Gustin, Alexander Kamb, Paul D Kassner, Shyun Li, Yihong Li, Kurt Morgenstern, Matthew Plant, Kim Quon, Astrid Ruefli-Brasse, Joanna Schmidt, Elissa Swearingen, Nigel Walker, Zhulun Wang, J E Vivienne Watson, Dineli Wickramasinghe, Mariwil Wong, Guifen Xu, Holger Wesche
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68328 (2013)
Sphingosine kinases (SPHKs) are enzymes that phosphorylate the lipid sphingosine, leading to the formation of sphingosine-1-phosphate (S1P). In addition to the well established role of extracellular S1P as a mitogen and potent chemoattractant, SPHK a
Externí odkaz:
https://doaj.org/article/dfda1f39979a456d9edd17f32579cba1
Autor:
Daniel J. Capon, Larisa Troitskaya, Nelson Lap Shun Chan, Marina Fomin, Ursula Edman, Brendon Frank, Jing Jin, Rachel Martinelli, Benjamin Z. Capon, Ginger A. Ferguson, Malcolm L. Gefter, Graham Simmons
The ability of antibodies and Fc-fusion proteins to bind multiple targets cooperatively is limited by their topology. Here we describe our discovery that ACE2 Fc-fusion proteins spontaneously cross-dimerize, forming topologically distinct “superdim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba62b122f626d16857231cf213e8ee67
https://doi.org/10.1101/2022.03.23.485397
https://doi.org/10.1101/2022.03.23.485397
Autor:
Michael C. Boyle, Rocio Hernandez, Brendon Frank, Qinghong Yan, Chi-Ming Li, Herve Lebrec, Tara Arvedson, Oliver Homann, Xiaoting Wang, Rebecca Goldstein, K.H. Kim, Benjamin Brooks, Christine M. Karbowski, Gregor Adams, Kelly Hensley
Publikováno v:
Toxicological Sciences
Feline McDonough Sarcoma-like tyrosine kinase 3 (FLT3), a tyrosine-protein kinase involved in hematopoiesis, is detectable on the cell surface of approximately 80% of leukemia isolates from adult patients with acute myeloid leukemia (AML). AMG 553 is
Autor:
Mercedesz Balazs, Christina Krupka, Ryan Case, Dan A. Rock, Brendon Frank, Tara Arvedson, Sascha Haubner, Michael von Bergwelt-Baildon, Rebecca Goldstein, Michael C. Boyle, Christine Sastri, Priya Koppikar, Angela Coxon, Anja Henn, Bettina Brauchle, Klaus H. Metzeler, Tobias Raum, Christoph Dahlhoff, Joachim Wahl, Christine M. Karbowski, Veit Bücklein, Marion Subklewe, Matthias Friedrich, Karsten Spiekermann, Matthew J. Rardin, Chi-Ming Li
Publikováno v:
Molecular cancer therapeutics. 19(9)
Despite advances in the treatment of acute myeloid leukemia (AML), novel therapies are needed to induce deeper and more durable clinical response. Bispecific T-cell Engager (BiTE) molecules, which redirect patient T cells to lyse tumor cells, are a c
Autor:
Mercedesz Balazs, Brendon Frank, Abraham Guerrero, Herve Lebrec, Yu-Ling Wei, Kyung Hoon Kim, Xiaoting Wang
Publikováno v:
Journal of Immunotoxicology, Vol 15, Iss 1, Pp 119-125 (2018)
The immunotoxic potential of drug candidates is assessed through the examination of results from a variety of studies and endpoints. While the functional assessment of CD8+ cytotoxic T-lymphocytes (CTL) is well-characterized in the clinic, the lack o
Autor:
Brendon Frank, Ben Brooks, Michael C. Boyle, Herve Lebrec, Gregor Adams, Oliver Homann, Qinghong Yan, Bradford W. Gibson, Rebecca Goldstein, Chi-Ming Li, Christine M. Karbowski, K.H. Kim, Tara Arvedson, Rocio Hernandez, Kelly Hensley
Publikováno v:
Journal of Clinical Oncology. 37:7032-7032
7032 Background: FMS-like tyrosine kinase 3 (FLT3) is a tyrosine-protein kinase involved in hematopoiesis. In acute myeloid leukemia (AML), higher FLT3 transcript levels, independent of the presence of FLT3 mutations, correlate with higher leukocyte
Publikováno v:
The Journal of Immunology. 198:151.2-151.2
The preclinical evaluation of therapeutic agents contributes to the understanding of associated risks and benefits. The non-human primate, and notably the cynomolgus macaque, is often a species of choice for such pharmacological and toxicological ass