Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions

Autor: Payne, RO, Silk, SE, Elias, SC, Miura, K, Diouf, A, Galaway, F, de Graaf, H, Brendish, NJ, Poulton, ID, Griffiths, OJ, Edwards, NJ, Jin, J, Labbé, GM, Alanine, DG, Siani, L, Di Marco, S, Roberts, R, Green, N, Berrie, E, Ishizuka, A.S., Nielsen, C.M., Bardelli, M., Partey, F.D., Ofori, M.F., Barfod, L., Wambua, J., Murungi, L.M., Osier, F.H., Biswas, S., McCarthy, J.S., Minassian, A.M., Ashfield, R., Viebig, N.K., Nugent, F.L., Douglas, A.D., Vekemans, J., Wright, G.J., Faust, S.N., Hill, A.V., Long, C.A., Lawrie, A.M., Draper, S.J.

Publikováno v: Payne, R O, Silk, S E, Elias, S C, Miura, K, Diouf, A, Galaway, F, de Graaf, H, Brendish, N J, Poulton, I D, Griffiths, O J, Edwards, N J, Jin, J, Labbé, G M, Alanine, D G, Siani, L, Di Marco, S, Roberts, R, Green, N, Berrie, E, Ishizuka, A S, Nielsen, C M, Bardelli, M, Partey, F D, Ofori, M F, Barfod, L, Wambua, J, Murungi, L M, Osier, F H, Biswas, S, McCarthy, J S, Minassian, A M, Ashfield, R, Viebig, N K, Nugent, F L, Douglas, A D, Vekemans, J, Wright, G J, Faust, S N, Hill, A V, Long, C A, Lawrie, A M & Draper, S J 2017, ' Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions ', JCI insight, vol. 2, no. 21, e96381 . https://doi.org/10.1172/jci.insight.96381

The development of a highly effective vaccine remains a key strategic goal to aid the control and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte-binding protein homolog 5 (RH5) has emerged as the most promisi

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Clinical Outcomes of Rapid Respiratory Virus Testing in Emergency Departments: A Systematic Review and Meta-Analysis.

Autor: Schober T; Department of Pediatrics, McGill University, Montreal, Quebec, Canada.; Dr von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Wong K; Department of Pediatrics, McGill University, Montreal, Quebec, Canada.; Research Institute McGill University Health Centre, Montreal, Quebec, Canada., DeLisle G; Department of Pediatrics, McGill University, Montreal, Quebec, Canada.; Department of Pediatrics, Université de Montréal, Montreal, Quebec, Canada., Caya C; Research Institute McGill University Health Centre, Montreal, Quebec, Canada., Brendish NJ; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, England.; Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, England.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, England., Clark TW; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, England.; Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, England.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, England., Dendukuri N; Research Institute McGill University Health Centre, Montreal, Quebec, Canada., Doan Q; Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada., Fontela PS; Department of Pediatrics, McGill University, Montreal, Quebec, Canada.; Research Institute McGill University Health Centre, Montreal, Quebec, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Gore GC; Schulich Library of Physical Sciences, Life Sciences, and Engineering, McGill University, Montreal, Quebec, Canada., Li P; Department of Pediatrics, McGill University, Montreal, Quebec, Canada.; Research Institute McGill University Health Centre, Montreal, Quebec, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., McGeer AJ; Department of Microbiology, Sinai Health System, Toronto, Ontario, Canada., Noël KC; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Robinson JL; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada., Suarthana E; Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.; Health Technology Assessment Unit, McGill University Health Centre, Montreal, Quebec, Canada., Papenburg J; Department of Pediatrics, McGill University, Montreal, Quebec, Canada.; Research Institute McGill University Health Centre, Montreal, Quebec, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.; Division of Microbiology, Department of Clinical Laboratory Medicine, McGill University Health Centre, Montreal, Quebec, Canada.

Publikováno v: JAMA internal medicine [JAMA Intern Med] 2024 May 01; Vol. 184 (5), pp. 528-536.

Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial.

Autor: Brendish NJ; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre and Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, UK. Electronic address: n.brendish@soton.ac.uk., Beard KR; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre and Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Malachira AK; Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Tanner AR; Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Sanga-Nyirongo L; Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Gwiggner M; Department of Gastroenterology, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Cummings JRF; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre and Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Department of Gastroenterology, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Moyses HE; NIHR Southampton Biomedical Research Centre and Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Clark TW; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre and Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, UK; University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Publikováno v: The Lancet. Infectious diseases [Lancet Infect Dis] 2023 Aug; Vol. 23 (8), pp. 945-955. Date of Electronic Publication: 2023 Apr 25.

FebriDx host response point-of-care testing improves patient triage for coronavirus disease 2019 (COVID-19) in the emergency department - ADDENDUM.

Autor: Mansbridge CT, Tanner AR, Beard KR, Borca F, Phan HTT, Brendish NJ, Poole S, Hill C, Kiuber M, Crouch R, Waddington D, Clark TW

Publikováno v: Infection control and hospital epidemiology [Infect Control Hosp Epidemiol] 2022 Aug; Vol. 43 (8), pp. 1099. Date of Electronic Publication: 2022 Apr 11.

Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19.

Autor: Legebeke J; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom., Lord J; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Penrice-Randal R; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Vallejo AF; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Poole S; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom.; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Brendish NJ; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom.; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Dong X; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Hartley C; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Holloway JW; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom., Lucas JS; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom.; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Williams AP; Cancer Sciences Division, Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom., Wheway G; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Strazzeri F; TopMD Precision Medicine Ltd, Southampton, United Kingdom., Gardner A; TopMD Precision Medicine Ltd, Southampton, United Kingdom., Schofield JPR; TopMD Precision Medicine Ltd, Southampton, United Kingdom., Skipp PJ; TopMD Precision Medicine Ltd, Southampton, United Kingdom.; Centre for Proteomic Research, School of Biological Sciences, University of Southampton, Southampton, United Kingdom., Hiscox JA; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, United Kingdom.; ASTAR Infectious Diseases Laboratories (ASTAR ID Labs), Agency for Science, Technology and Research (ASTAR) Singapore, Singapore, Singapore., Polak ME; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom., Clark TW; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom.; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Baralle D; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 May 19; Vol. 13, pp. 853265. Date of Electronic Publication: 2022 May 19 (Print Publication: 2022).