Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis.

Autor: Li J; Department of Chemistry, Washington University in St. Louis , St. Louis, Missouri 63130-4889, United States., Wei H; Biologics Development, Bristol-Myers Squibb , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States., Krystek SR Jr; Molecular Structure & Design, Bristol-Myers Squibb , Rt. 206 & Province Line Rd., Princeton, New Jersey 08543, United States., Bond D; Process Development, Bristol-Myers Squibb , 1201 Eastlake Ave E., Seattle Washington 98102, United States., Brender TM; Discovery Biology, Bristol-Myers Squibb , 1201 Eastlake Ave E., Seattle Washington 98102, United States., Cohen D; Protein Science, Bristol-Myers Squibb , Rt. 206 & Province Line Rd., Princeton, New Jersey 08543, United States., Feiner J; Applied Genomics, Bristol-Myers Squibb , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States., Hamacher N; Molecular Structure & Design, Bristol-Myers Squibb , Rt. 206 & Province Line Rd., Princeton, New Jersey 08543, United States., Harshman J; Molecular Structure & Design, Bristol-Myers Squibb , Rt. 206 & Province Line Rd., Princeton, New Jersey 08543, United States., Huang RY; Bioanalytical and Discovery Analytical Sciences, Research and Development, Bristol-Myers Squibb , Rt. 206 & Province Line Rd., Princeton, New Jersey 08543, United States., Julien SH; Protein Engineering, Bristol-Myers Squibb , 1201 Eastlake Ave E., Seattle Washington 98102, United States., Lin Z; Protein Science, Bristol-Myers Squibb , Rt. 206 & Province Line Rd., Princeton, New Jersey 08543, United States., Moore K; Protein Science, Bristol-Myers Squibb , Rt. 206 & Province Line Rd., Princeton, New Jersey 08543, United States., Mueller L; Bioanalytical and Discovery Analytical Sciences, Research and Development, Bristol-Myers Squibb , Rt. 206 & Province Line Rd., Princeton, New Jersey 08543, United States., Noriega C; Protein Engineering, Bristol-Myers Squibb , 1201 Eastlake Ave E., Seattle Washington 98102, United States., Sejwal P; Bioanalytical and Discovery Analytical Sciences, Research and Development, Bristol-Myers Squibb , Rt. 206 & Province Line Rd., Princeton, New Jersey 08543, United States., Sheppard P; Protein Engineering, Bristol-Myers Squibb , 1201 Eastlake Ave E., Seattle Washington 98102, United States., Stevens B; Protein Engineering, Bristol-Myers Squibb , 1201 Eastlake Ave E., Seattle Washington 98102, United States., Chen G; Bioanalytical and Discovery Analytical Sciences, Research and Development, Bristol-Myers Squibb , Rt. 206 & Province Line Rd., Princeton, New Jersey 08543, United States., Tymiak AA; Bioanalytical and Discovery Analytical Sciences, Research and Development, Bristol-Myers Squibb , Rt. 206 & Province Line Rd., Princeton, New Jersey 08543, United States., Gross ML; Department of Chemistry, Washington University in St. Louis , St. Louis, Missouri 63130-4889, United States., Schneeweis LA; Protein Science, Bristol-Myers Squibb , Rt. 206 & Province Line Rd., Princeton, New Jersey 08543, United States.

Publikováno v: Analytical chemistry [Anal Chem] 2017 Feb 21; Vol. 89 (4), pp. 2250-2258. Date of Electronic Publication: 2017 Feb 09.

Covalent labeling and mass spectrometry reveal subtle higher order structural changes for antibody therapeutics.

Autor: Limpikirati, Patanachai, Hale, John E., Hazelbaker, Mark, Huang, Yongbo, Jia, Zhiguang, Yazdani, Mahdieh, Graban, Eric M., Vaughan, Robert C., Vachet, Richard W.

Publikováno v: mAbs; Apr2019, Vol. 11 Issue 3, p463-476, 14p

Exploring the potential of 3D Zernike descriptors and SVM for protein–protein interface prediction.

Autor: Daberdaku, Sebastian¹ sebastian.daberdaku@dei.unipd.it, Ferrari, Carlo¹ carlo.ferrari@unipd.it

Publikováno v: BMC Bioinformatics. 2/6/2018, Vol. 19, p1-1. 1p. 8 Charts, 4 Graphs.

Determination of IL-23 Pharmacokinetics by Highly Sensitive Accelerator Mass Spectrometry and Subsequent Modeling to Project IL-23 Suppression in Psoriasis Patients Treated with Anti-IL-23 Antibodies.

Autor: Zhang, Ting-Ting, Ma, Junli, Durbin, Kenneth R., Montavon, Timothy, Lacy, Susan E., Jenkins, Gary J., Doktor, Stella, Kalvass, J. Cory

Publikováno v: AAPS Journal; Sep2019, Vol. 21 Issue 5, pN.PAG-N.PAG, 1p