Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Brenden W. Smith"'
Publikováno v:
Stem Cells International, Vol 2016 (2016)
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that increases the expression of detoxifying enzymes upon ligand stimulation. Recent studies now suggest that novel endogenous roles of the AHR exist throughout developmen
Externí odkaz:
https://doaj.org/article/377cd6377cae445d82f756f7ca529a32
Autor:
George J. Murphy, Brenden W. Smith
Publikováno v:
Current Opinion in Hematology. 21:430-437
Stem cells are an important tool for the study of ex-vivo models of megakaryopoiesis and the production of functional platelets. In this manuscript, we review the optimization of megakaryocyte and platelet differentiation and discuss the mechanistic
Autor:
Alan D. Michelson, Gustavo Mostoslavsky, Ashley J. Parks, Roger Théberge, George J. Murphy, Jessalyn M. Ubellacker, Amy Leung, David H.K. Chui, Brenden W. Smith, Paul Gadue, Darrell N. Kotton, Martin H. Steinberg, Shirley K. Nah, Catherine E. Costello, David H. Sherr, Mark E. McComb, Sarah S. Rozelle, Stefano Monti, Andrew L. Frelinger, Deborah L. French
Publikováno v:
Blood. 122:376-385
The evolutionarily conserved aryl hydrocarbon receptor (AhR) has been studied for its role in environmental chemical-induced toxicity. However, recent studies have demonstrated that the AhR may regulate the hematopoietic and immune systems during dev
Autor:
George J. Murphy, Elizabeth A. Stanford, Esther Landesman-Bollag, Stefano Monti, Brenden W. Smith, Olga Novikov, David H. Sherr, David C. Seldin, Zhongyan Wang, Francesca Mulas
Publikováno v:
BMC Biology
Background Self-renewing, chemoresistant breast cancer stem cells are believed to contribute significantly to cancer invasion, migration and patient relapse. Therefore, the identification of signaling pathways that regulate the acquisition of stem-li
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Stem Cells International
Stem Cells International
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that increases the expression of detoxifying enzymes upon ligand stimulation. Recent studies now suggest that novel endogenous roles of the AHR exist throughout developmen
Autor:
Elizabeth A. Stanford, George J. Murphy, A. Ramirez-Cardenas, Francesca Mulas, Z. Wang, Brenden W. Smith, Stefano Monti, Olga Novikov, M.V. Bais, M.A. Kukuruzinska, Esther Landesman-Bollag, David H. Sherr
Publikováno v:
Toxicology Letters. 259:S20
Autor:
Darrell N. Kotton, Spencer K. Sullivan, Deborah L. French, George J. Murphy, Seonmi Park, Sarah S. Rozelle, Brenden W. Smith, Paul Gadue, Jason A. Mills, Amulya Iyer, Gustavo Mostoslavsky, Andreia Gianotti Sommer
Publikováno v:
Journal of Visualized Experiments.
Through the ectopic expression of four transcription factors, Oct4, Klf4, Sox2 and cMyc, human somatic cells can be converted to a pluripotent state, generating so-called induced pluripotent stem cells (iPSCs)(1-4). Patient-specific iPSCs lack the et
Autor:
Jenny M. Jean, George J. Murphy, Amel Omari, Robert Lafyatis, Paul Gadue, Cesar Sommer, Marie-France Demierre, Lei Ying, Brenden W. Smith, Gustavo Mostoslavsky, Christopher C. Ford, Jyh-Chang Jean, Deborah L. French, Aba Somers, Andreia Gianotti Sommer, Daniel J. Weiss, Jason A. Mills, Darrell N. Kotton
Publikováno v:
Stem cells (Dayton, Ohio). 28(10)
The development of methods to achieve efficient reprogramming of human cells while avoiding the permanent presence of reprogramming transgenes represents a critical step toward the use of induced pluripotent stem cells (iPSC) for clinical purposes, s
Autor:
George J. Murphy, Efthymia Melista, Brenden W. Smith, Ehimen Aneni, Martin H. Steinberg, Sarah S. Rozelle, Abdulrahman Alsultan, Paola Sebastiani, David H.K. Chui, Gustavo Mostoslavsky, Clinton T. Baldwin
Publikováno v:
Blood. 120:3233-3233
Abstract 3233 As they can be generated from the somatic cells of any individual, induced pluripotent stem cells (iPSC) represent renewable, potentially unlimited cell sources that circumvent the possibility of inappropriate immune response and open t
Autor:
George J. Murphy, Paul Gadue, Brenden W. Smith, David H. Sherr, Sarah S. Rozelle, Martin H. Steinberg, Deborah L. French, David H.K. Chui
Publikováno v:
Blood. 120:766-766
Abstract 766 The evolutionarily conserved aryl hydrocarbon receptor (AhR), a member of the basic helix-loop-helix Per-ARNT-Sim family, has been studied for its role in environmental chemical-induced toxicity. Recent studies now demonstrate that the A