Zobrazeno 1 - 10
of 425
pro vyhledávání: '"Brendan W, Wren"'
Autor:
Emily J. Kay, Manoj K. Dooda, Joseph C. Bryant, Amanda J. Reid, Brendan W. Wren, Jerry M. Troutman, Matthew A. Jorgenson
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Background Bacterial surface glycans are assembled by glycosyltransferases (GTs) that transfer sugar monomers to long-chained lipid carriers. Most bacteria employ the 55-carbon chain undecaprenyl phosphate (Und-P) to scaffold glycan assembly
Externí odkaz:
https://doaj.org/article/0c94afe6c3a647e5b5a37e7a029dae63
Autor:
Burhan Lehri, Elizabeth Atkins, Timothy A. Scott, Sherif Abouelhadid, Brendan W. Wren, Jon Cuccui
Publikováno v:
Microbial Biotechnology, Vol 17, Iss 6, Pp n/a-n/a (2024)
Abstract The application of bacterial oligosaccharyltransferases (OSTs) such as the Campylobacter jejuni PglB for glycoengineering has attracted considerable interest in glycoengineering and glycoconjugate vaccine development. However, PglB has limit
Externí odkaz:
https://doaj.org/article/a3b5ae37e13f4b36941199417dc21b76
Autor:
Sherif Abouelhadid, Elizabeth R. Atkins, Emily J. Kay, Ian J. Passmore, Simon J. North, Burhan Lehri, Paul Hitchen, Eirik Bakke, Mohammed Rahman, Janine T. Bossé, Yanwen Li, Vanessa S. Terra, Paul R. Langford, Anne Dell, Brendan W. Wren, Jon Cuccui
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-13 (2023)
Abstract Conjugate vaccines produced either by chemical or biologically conjugation have been demonstrated to be safe and efficacious in protection against several deadly bacterial diseases. However, conjugate vaccine assembly and production have sev
Externí odkaz:
https://doaj.org/article/7c268aec51534a47a4626a4fff3d99d6
Autor:
Mark A. Harrison, Rebecca J. Farthing, Nyasha Allen, Lucy M. Ahern, Kristian Birchall, Michael Bond, Harparkash Kaur, Brendan W. Wren, Julien R. C. Bergeron, Lisa F. Dawson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Treatment of Clostridioides difficile infection (CDI) is expensive and complex, with a high proportion of patients suffering infection relapse (20–35%), and some having multiple relapses. A healthy, unperturbed gut microbiome provides colo
Externí odkaz:
https://doaj.org/article/626593c26e0f40ee86a76ba8bb599235
Autor:
Ricardo Corona-Torres, Prerna Vohra, Cosmin Chintoan-Uta, Abi Bremner, Vanessa S. Terra, Marta Mauri, Jon Cuccui, Lonneke Vervelde, Brendan W. Wren, Mark P. Stevens
Publikováno v:
Vaccines, Vol 12, Iss 4, p 395 (2024)
Campylobacter is a major cause of acute gastroenteritis in humans, and infections can be followed by inflammatory neuropathies and other sequelae. Handling or consumption of poultry meat is the primary risk factor for human campylobacteriosis, and C.
Externí odkaz:
https://doaj.org/article/425311bf8ef64f3aa1a2c9d2faef25d0
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract The Group A Carbohydrate (GAC) is a defining feature of Group A Streptococcus (Strep A) or Streptococcus pyogenes. It is a conserved and simple polysaccharide, comprising a rhamnose backbone and GlcNAc side chains, further decorated with gly
Externí odkaz:
https://doaj.org/article/4a853855392a45c3981d9cd12eabe8f9
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background Glycoengineering, in the biotechnology workhorse bacterium, Escherichia coli, is a rapidly evolving field, particularly for the production of glycoconjugate vaccine candidates (bioconjugation). Efficient production of glycoconjuga
Externí odkaz:
https://doaj.org/article/9f731b36816a4c29ae3d8c183184edb7
Autor:
Geunhye Hong, Cadi Davies, Zahra Omole, Janie Liaw, Anna D. Grabowska, Barbara Canonico, Nicolae Corcionivoschi, Brendan W. Wren, Nick Dorrell, Abdi Elmi, Ozan Gundogdu
Publikováno v:
Cellular Microbiology, Vol 2023 (2023)
Campylobacter jejuni is the major bacterial cause of foodborne gastroenteritis worldwide. Mechanistically, how this pathogen interacts with intrinsic defence machinery of human intestinal epithelial cells (IECs) remains elusive. To address this, we i
Externí odkaz:
https://doaj.org/article/44ad18a07c584fa8ba09f381bec1ebca
Autor:
Arnone Nithichanon, Chidchamai Kewcharoenwong, Hudadini Da-oh, Sirithorn Surajinda, Aranya Khongmee, Surathinee Koosakunwat, Brendan W. Wren, Richard A. Stabler, Jeremy S. Brown, Ganjana Lertmemongkolchai
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Infections by Acinetobacter species are recognized as a serious global threat due to causing severe disease and their high levels of antibiotic resistance. Acinetobacter baumannii is the most prevalent pathogen in the genus, but infection by
Externí odkaz:
https://doaj.org/article/499c8e4bbeea4e71955c22b6cfcfc8e1
Autor:
Vanessa S. Terra, Marta Mauri, Thippeswamy H. Sannasiddappa, Alexander A. Smith, Mark P. Stevens, Andrew J. Grant, Brendan W. Wren, Jon Cuccui, the Glycoengineering of Veterinary Vaccines consortium (GoVV)
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-14 (2022)
Abstract Background Campylobacter is an animal and zoonotic pathogen of global importance, and a pressing need exists for effective vaccines, including those that make use of conserved polysaccharide antigens. To this end, we adapted Protein Glycan C
Externí odkaz:
https://doaj.org/article/9ef74ec04b684752a39faf7ab2b79bf2