Zobrazeno 1 - 10
of 487
pro vyhledávání: '"Brendan Twamley"'
Autor:
James P. McKeown, Andrew J. Byrne, Sandra A. Bright, Clara E. Charleton, Shubhangi Kandwal, Ivan Čmelo, Brendan Twamley, Anthony M. McElligott, Darren Fayne, Niamh M. O’Boyle, D. Clive Williams, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1034 (2024)
Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells, and it is the most frequent form of leukemia diagnosed in Western countries. It is characterized by the proliferation and accumulation of neoplastic B lymphocytes in the blood, lym
Externí odkaz:
https://doaj.org/article/ec8f4b69512c421787aea349de4351eb
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 79, Iss 7, Pp 592-595 (2023)
The crystal structure of (R,R)-4-bromo-2-{4-[4-bromo-1-(4-toluenesulfonyl)-1H-pyrrol-2-yl]-1,3-dinitrobutan-2-yl}-1-(4-toluenesulfonyl)-1H-pyrrole (1, C26H24Br2N4O8S2) is presented. The title compound was isolated in suitable yield as a by-product in
Externí odkaz:
https://doaj.org/article/5677d8ce108e4805bfeff6283ba5e29a
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 79, Iss 3, Pp 157-162 (2023)
The crystal structures of three S-(pyridin-2-yl) benzothioesters with varying para-phenyl substituents are presented, namely, S-(pyridin-2-yl) 4-nitrobenzothioate (1, C12H8N2O3S), S-(pyridin-2-yl) 4-methylbenzothioate (2, C13H11NO2S) and S-(pyridin-2
Externí odkaz:
https://doaj.org/article/58648ae1d4094bd08ab375db24253923
Autor:
Andrew J. Byrne, Sandra A. Bright, James. P. McKeown, Adam Bergin, Brendan Twamley, Anthony M. McElligott, Sara Noorani, Shubhangi Kandwal, Darren Fayne, Niamh M. O’Boyle, D. Clive Williams, Mary J. Meegan
Publikováno v:
Molecules, Vol 28, Iss 24, p 8095 (2023)
Chronic lymphocytic leukaemia (CLL) is a malignancy of the immune B lymphocyte cells and is the most common leukaemia diagnosed in developed countries. In this paper, we report the synthesis and antiproliferative effects of a series of (E)-9-(2-nitro
Externí odkaz:
https://doaj.org/article/4eb2cf5d956c4622b0b26f06f0efdc53
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2330 (2023)
Several studies have demonstrated the feasibility of in situ co-crystallization in different pharmaceutical processes such as spray drying, hot melt extrusion, and fluidized bed granulation (FBG) to produce co-crystal-in-excipient formulations. Howev
Externí odkaz:
https://doaj.org/article/f4c2c2332bd044058093c5cf660f2bb9
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 2287-2294 (2021)
N-Protected oxindole derivatives of unprecedented malleability bearing ester moieties at C-3 have been shown to participate in enantioselective phase-transfer-catalysed alkylations promoted by ad-hoc designed quaternary ammonium salts derived from qu
Externí odkaz:
https://doaj.org/article/52d2338f98584855a7d75a469a68f667
Autor:
Shu Wang, Azizah M. Malebari, Thomas F. Greene, Shubhangi Kandwal, Darren Fayne, Seema M. Nathwani, Daniela M. Zisterer, Brendan Twamley, Niamh M. O’Boyle, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 1000 (2023)
A series of novel 3-(prop-1-en-2-yl)azetidin-2-one, 3-allylazetidin-2-one and 3-(buta-1,3-dien-1-yl)azetidin-2-one analogues of combretastatin A-4 (CA-4) were designed and synthesised as colchicine-binding site inhibitors (CBSI) in which the ethylene
Externí odkaz:
https://doaj.org/article/a88c634232124ff8893931a453eafe31
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 76, Iss 8, Pp 1187-1194 (2020)
A series of related substituted 1-(3,4,5-trimethoxyphenyl)azetidin-2-ones have been characterized: 3-(4-fluorophenyl)-4-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, C25H24FNO5 (1), 3-(furan-2-yl)-4-(4-methoxyphenyl)-1-(3,4,5-trimethoxy
Externí odkaz:
https://doaj.org/article/2bae3bc2b3bc400abee1abbb0cf21ac1
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 76, Iss 5, Pp 703-709 (2020)
Reaction of 2-(4,4-dimethyl-2-oxazolin-2-yl)aniline (H2-L1) with one equivalent of Na[N(SiMe3)2] in toluene afforded pale-yellow crystals of tetrameric poly[bis[μ3-2-(4,4-dimethyl-2-oxazolin-2-yl)anilinido][μ2-2-(4,4-dimethyl-2-oxazolin-2-yl)anilin
Externí odkaz:
https://doaj.org/article/367a495bcf914d9f81b6417b49461c4f
Autor:
Christopher J. Kingsbury, Keith J. Flanagan, Marc Kielmann, Brendan Twamley, Mathias O. Senge
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 76, Iss 2, Pp 214-220 (2020)
The crystal structures of the title compounds, two solvates (CHCl3 and THF) of a symmetric and highly substituted porphyrin, C44H2Br8F20N4 or OBrTPFPP, are described. These structures each feature a non-planar porphyrin ring, exhibiting a similar con
Externí odkaz:
https://doaj.org/article/f8a62f49836f42d49c339363b72a53c4