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TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells
Publikováno v:
Biochemical Journal. 479:1891-1907
A conditional knock-in mouse was generated in which the TAK1 catalytic subunit was largely replaced by the kinase-inactive TAK1[D175A] mutant in immune cells. The activation of p38α MAP kinase, c-Jun N-terminal kinases 1 and 2 (JNK1/2) and the canon