Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Brendan T, Griffin"'
Autor:
Sofia Cussotto, Jacinta Walsh, Anna V. Golubeva, Alexander V. Zhdanov, Conall R. Strain, Fiona Fouhy, Catherine Stanton, Timothy G. Dinan, Niall P. Hyland, Gerard Clarke, John F. Cryan, Brendan T. Griffin
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103307- (2021)
Background: The role of the gut microbiome in the biotransformation of drugs has recently come under scrutiny. It remains unclear whether the gut microbiome directly influences the extent of drug absorbed after oral administration and thus potentiall
Externí odkaz:
https://doaj.org/article/90a73ebf29cd4ea7aae7e7a551725c50
Autor:
Mark McAllister, Talia Flanagan, Susan Cole, Andreas Abend, Evangelos Kotzagiorgis, Jobst Limberg, Heather Mead, Victor Mangas-Sanjuan, Paul A. Dickinson, Andrea Moir, Xavier Pepin, Diansong Zhou, Christophe Tistaert, Aristides Dokoumetzidis, Om Anand, Maxime Le Merdy, David B. Turner, Brendan T. Griffin, Adam Darwich, Jennifer Dressman, Claire Mackie
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1010 (2022)
A webinar series that was organised by the Academy of Pharmaceutical Sciences Biopharmaceutics focus group in 2021 focused on the challenges of developing clinically relevant dissolution specifications (CRDSs) for oral drug products. Industrial scien
Externí odkaz:
https://doaj.org/article/ef6f2c994c1b4a04809bf2645feb40a0
Autor:
Laura J. Henze, Niklas J. Koehl, Joseph P. O'Shea, René Holm, Maria Vertzoni, Brendan T. Griffin
Publikováno v:
International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)
A preclinical porcine model that reliably predicts human food effect of fenofibrate was developed. Fenofibrate was administered to pigs as model compound with a positive food effect. Two different types of fed conditions were explored: a FDA style br
Externí odkaz:
https://doaj.org/article/b0e53c7d835c4cd195b7ef88274c3811
Autor:
Harriet Bennett-Lenane, Joseph P. O’Shea, Jack D. Murray, Alexandra-Roxana Ilie, René Holm, Martin Kuentz, Brendan T. Griffin
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1398 (2021)
In response to the increasing application of machine learning (ML) across many facets of pharmaceutical development, this pilot study investigated if ML, using artificial neural networks (ANNs), could predict the apparent degree of supersaturation (a
Externí odkaz:
https://doaj.org/article/7b06bc13a1894a9ba8b0eaab5f9147a4
Autor:
Joanne Heade, Fiona McCartney, Miguel Chenlo, Olga Moreno Marro, Maja Severic, Robert Kent, Sinead B. Bleiel, Clara V. Alvarez, Brendan T. Griffin, David J. Brayden
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 656 (2021)
For many diabetics, daily, lifelong insulin injections are required to effectively manage blood glucose levels and the complications associated with the disease. This can be a burden and reduces patient quality of life. Our goal was to develop a more
Externí odkaz:
https://doaj.org/article/c01c94d1f0874249885cdebbad75c0fe
Publikováno v:
Oral Drug Delivery for Modified Release Formulations. :137-160
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 564 (2020)
Increasing numbers of beyond Rule-of-Five drugs are emerging from discovery pipelines, generating a need for bio-enabling formulation approaches, such as lipid-based formulations (LBF), to ensure maximal in vivo exposure. However, many drug candidate
Externí odkaz:
https://doaj.org/article/e8396e284ac84c49a16691b9fa38b952
Autor:
Laura J. Henze, Christos Reppas, Jennifer B. Dressman, Marina Statelova, Chara Litou, Christina Pentafragka, Patrick J O'Dwyer, Karl J. Box, Brendan T. Griffin, Maria Vertzoni
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:437-446
ObjectivesTo summarise key contributions of the Pharmaceutical Education and Research with Regulatory Links (PEARRL) project (2016–2020) to the optimisation of existing and the development of new biopharmaceutics tools for evaluating the in vivo pe
Autor:
Sebastian Jakobsen, Lorraine Gaenaelle Gé, Maria Pedersen, Brendan T. Griffin, René Holm, Carsten Uhd Nielsen
Publikováno v:
International journal of pharmaceutics. 624
The aim of the present study was to investigate if mucus applied to Caco-2 cell monolayers protects cells from high concentrations of surfactants, while still allowing for an identification of the surfactant's inhibitory effects on P-glycoprotein (P-
Autor:
Andreas Marx, Niklas J. Koehl, René Holm, Brendan T. Griffin, John J. Keating, Thomas De Vijlder, Martin Kuentz, Laura J. Henze
Publikováno v:
Koehl, N J, Henze, L J, Holm, R, Kuentz, M, Keating, J J, De Vijlder, T, Marx, A & Griffin, B T 2022, ' Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax ', Journal of Pharmaceutical Sciences, vol. 111, no. 1, pp. 164-174 . https://doi.org/10.1016/j.xphs.2021.09.008
Lipid based formulations (LBF) have shown to overcome food dependent bioavailability for some poorly water-soluble drugs. However, the utility of LBFs can be limited by low dose loading due to a low drug solubility in LBF vehicles. This study investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891f5094421f520bc605cb9eabbe0467
https://portal.findresearcher.sdu.dk/da/publications/8739040f-91e7-49b7-ae10-38595606aa5f
https://portal.findresearcher.sdu.dk/da/publications/8739040f-91e7-49b7-ae10-38595606aa5f