Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Brendan Mullan"'
Autor:
Stefanie Stallard, Masha G. Savelieff, Kyle Wierzbicki, Brendan Mullan, Zachary Miklja, Amy Bruzek, Taylor Garcia, Ruby Siada, Bailey Anderson, Benjamin H. Singer, Rintaro Hashizume, Angel M. Carcaboso, Kaitlin Q. McMurray, Jason Heth, Karin Muraszko, Patricia L. Robertson, Rajen Mody, Sriram Venneti, Hugh Garton, Carl Koschmann
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-4 (2018)
Externí odkaz:
https://doaj.org/article/36b293d203c6459a8f4a9bd2839a5f28
Autor:
Sabine Mueller, Rodrigo Cartaxo, Viveka Nand Yadav, Rajen Mody, Cassie Kline, Alyssa Paul, Zachary Miklja, Brendan Mullan, Patricia L. Robertson, Ruby Siada, Marcia Leonard, Sriram Venneti, Taylor Garcia, Amy K. Bruzek, Stefanie Stallard, Hugh J. L. Garton, Bernard L. Marini, Carl Koschmann, Chase Thomas, Kyle Wierzbicki, Jann N. Sarkaria, Arul M. Chinnaiyan, Theodore Nicolaides, Daniel R. Wahl, Sarah Leary, Chandan Kumar-Sinha, Chana Glasser, Hemant Parmar, Jessica R. Cummings, Ian Wolfe, Tao Yang, Timothy N. Phoenix, Manjunath P. Pai
Publikováno v:
J Clin Invest
BackgroundPediatric and adult high-grade glioma (HGG) frequently harbor PDGFRA alterations. We hypothesized that co-treatment with everolimus may improve the efficacy of dasatinib in PDGFRα-driven glioma through combinatorial synergism and increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0ce4e71ab88ca54cd3101713c621d9
https://doi.org/10.1172/jci133310
https://doi.org/10.1172/jci133310
Autor:
Arul M. Chinnaiyan, Derek Dang, Nicholas K. Foreman, Jill Bayliss, Karin M. Muraszko, Fusheng Yang, Martin P. Ogrodzinski, Sriram Venneti, Debra Hawes, Li Jiang, Siva Kumar Natarajan, Andrew M. Donson, Drew Pratt, Stefan Sweha, Javad Nazarian, Chan Chung, Benita Tamrazi, Christopher Dunham, Hugh J. L. Garton, Joanna J. Phillips, Jason Heth, Sophia Y. Lunt, Deepak Nagrath, Brendan Mullan, Marcin Cieslik, Jin Heon, Marcel Kool, Stefan Bluml, Chao Lu, Abhinav Achreja, Andrey Korshunov, C. David Allis, Benjamin R. Sabari, Miriam Bornhorst, Matthew Pun, Juliette Hukin, Pooja Panwalkar, Olamide Animasahun, Andrea Griesinger, Stefan M. Pfister, Richard J. Gilbertson, Mariella G. Filbin, Alexander R. Judkins, Stephen Yip, Carl Koschmann
Publikováno v:
Sci Transl Med
Science translational medicine, vol 13, iss 614
Science translational medicine, vol 13, iss 614
Childhood posterior fossa group A ependymomas (PFAs) have limited treatment options and bear dismal prognoses compared to group B ependymomas (PFBs). PFAs overexpress the oncohistone-like protein EZHIP (enhancer of Zeste homologs inhibitory protein),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb4e379d0aa8db8191decfaff591c93
https://doi.org/10.1126/scitranslmed.abc0497
https://doi.org/10.1126/scitranslmed.abc0497
Autor:
Dana Messinger, Micah K Harris, Jessica R Cummings, Chase Thomas, Tao Yang, Stefan R Sweha, Rinette Woo, Robert Siddaway, Martin Burkert, Stefanie Stallard, Tingting Qin, Brendan Mullan, Ruby Siada, Ramya Ravindran, Michael Niculcea, Abigail R Dowling, Joshua Bradin, Kevin F Ginn, Melissa A H Gener, Kathleen Dorris, Nicholas A Vitanza, Susanne V Schmidt, Jasper Spitzer, Jiang Li, Mariella G Filbin, Xuhong Cao, Maria G Castro, Pedro R Lowenstein, Rajen Mody, Arul Chinnaiyan, Pierre-Yves Desprez, Sean McAllister, Matthew D Dun, Cynthia Hawkins, Sebastian M Waszak, Sriram Venneti, Carl Koschmann, Viveka Nand Yadav
Publikováno v:
Neuro-oncology.
Background Diffuse midline gliomas (DMG) are highly invasive brain tumors with rare survival beyond two years past diagnosis and limited understanding of the mechanism behind tumor invasion. Previous reports demonstrate upregulation of the protein ID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabf6a54c13113f6039ef68b6ed1211a
https://pubmed.ncbi.nlm.nih.gov/35605606
https://pubmed.ncbi.nlm.nih.gov/35605606
Autor:
Dana Messinger, Micah Harris, Jessica Cummings, Chase Thomas, Tao Yang, Stefan Sweha, Rinette Woo, Robert Siddaway, Martin Burkert, Stefanie Stallard, Tingting Qin, Brendan Mullan, Ruby Siada, Ramya Ravindran, Michael Niculcea, Abigail Dowling, Joshua Bradin, Kevin Ginn, Melissa Gener, Kathleen Dorris, Nicholas Vitanza, Susanne Schmidt, Jasper Spitzer, Jiang Li, Mariella Filbin, Xuhong Cao, Maria Castro, Pedro Lowenstein, Rajen Mody, Arul Chinnaiyan, Pierre-Yves Desprez, Sean McAllister, Matthew Dun, Cynthia Hawkins, Sebastian Waszak, Sriram Venneti, Carl Koschmann, Viveka Yadav
Publikováno v:
Neuro-Oncology. 24:vii40-vii40
Diffuse midline gliomas (DMG) are highly invasive brain tumors with rare survival beyond two years past diagnosis. The mechanism behind tumor invasion is currently not well understood. Previous reports demonstrate upregulation of the protein ID1 with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8942019e5e54f05553cd3203be6dfe19
https://doi.org/10.1093/neuonc/noac209.158
https://doi.org/10.1093/neuonc/noac209.158
Autor:
Tingting Qin, Brendan Mullan, Ramya Ravindran, Dana Messinger, Ruby Siada, Jessica R. Cummings, Micah Harris, Ashwath Muruganand, Kalyani Pyaram, Zachary Miklja, Mary Reiber, Taylor Garcia, Dustin Tran, Carla Danussi, Jacqueline Brosnan-Cashman, Drew Pratt, Xinyi Zhao, Alnawaz Rehemtulla, Maureen A. Sartor, Sriram Venneti, Alan K. Meeker, Jason T. Huse, Meredith A. Morgan, Pedro R. Lowenstein, Maria G. Castro, Viveka Nand Yadav, Carl Koschmann
Publikováno v:
Cell Rep
ATRX, a chromatin remodeler protein, is recurrently mutated in H3F3A-mutant pediatric glioblastoma (GBM) and isocitrate dehydrogenase (IDH)-mutant grade 2/3 adult glioma. Previous work has shown that ATRX-deficient GBM cells show enhanced sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb523ded8c410a4174984de5b746127a
https://pubmed.ncbi.nlm.nih.gov/35021084
https://pubmed.ncbi.nlm.nih.gov/35021084
Autor:
Sarah Leary, Carl Koschmann, Amy K. Bruzek, Rameen Beroukhim, Shakti H. Ramkissoon, Theodore Nicolaides, Susan N. Chi, Bonnie Cole, Zachary Miklja, Brendan Mullan, Cassie Kline-Nunnally, Keith L. Ligon, Maryam Fouladi, Angela C. Gauthier, Sabine Mueller, Bernard L. Marini, D William Parsons, Amy L. Pasternak, Taylor Garcia, Christie Atchison, Pratiti Bandopadhayay, Stefanie Stallard
Publikováno v:
Neuro Oncol
As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve with important implications for the standard of care for clinical ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e1aee8d94716e092aed73c74fba4e9
https://doi.org/10.1093/neuonc/noz022
https://doi.org/10.1093/neuonc/noz022
Autor:
Kevin Ginn, Pierre-Yves Desprez, Micah Harris, Cynthia Hawkins, Michael Niculcea, Chase Thomas, Maria G. Castro, Sriram Venneti, Tao Yang, Melissa Gener, Cummings, Xuhong Cao, Sandra S. McAllister, Stefanie Stallard, Messinger D, Jasper Spitzer, Carl Koschmann, Mariella G. Filbin, Chinnaiyan A, Tingting Qin, Pedro R. Lowenstein, Sebastian M. Waszak, Kathleen Dorris, Jiang Li, Viveka Yadav, Burkert M, Ramya Ravindran, Robert Siddaway, Rinette Woo, Susanne V. Schmidt, Ruby Siada, Rajen Mody, Brendan Mullan, Nicholas A Vitanza
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive brain tumor with rare survival beyond two years. This poor prognosis is largely due to the tumor’s highly infiltrative and invasive nature. Previous reports demonstrate upregulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4a6667772b4c5047c8ed9961739ba7e
https://doi.org/10.1101/2021.05.10.443452
https://doi.org/10.1101/2021.05.10.443452
Autor:
Micah Harris, Brendan Mullan, Jacqueline A. Brosnan-Cashman, Carla Danussi, Taylor Garcia, Carl Koschmann, Alnawaz Rehemtulla, Mary Reiber, Zachary Miklja, Sriram Venneti, Kalyani Pyaram, Xinyi Zhao, Tingting Qin, Jessica R. Cummings, Drew Pratt, Dustin Tran, Maureen A. Sartor, Ashwath Muruganand, Ramya Ravindran, Meredith A. Morgan, Alan K. Meeker, Viveka Nand Yadav, Maria G. Castro, Pedro R. Lowenstein, Ruby Siada, Jason T. Huse
Publikováno v:
SSRN Electronic Journal.
ATRX, a chromatin remodeler protein, is recurrently mutated in H3F3A-mutant pediatric glioblastoma (GBM) and IDH-mutant grade 2/3 adult glioma. Previous work has shown that ATRX-deficient GBM cells show enhanced sensitivity to irradiation, but the et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93f1f17b25d179e68a7ec17c26e17236
https://doi.org/10.2139/ssrn.3872044
https://doi.org/10.2139/ssrn.3872044
Autor:
Carl Koschmann, Abed Rahman Kawakibi, Rohinton Tarapore, Sharon Gardner, Chase Thomas, Rodrigo Cartaxo, Viveka Yadav, Andrew Chi, Sylvia Kurz, Patrick Wen, Isabel Arrillaga, Tracy Batchelor, Nicholas Butowski, Ashley Sumrall, Nicole Shonka, Rebecca Harrison, John De Groot, Minesh Mehta, Yazmin Odia, Matthew Hall, Doured Daghistani, Timothy Cloughesy, Benjamin Ellingson, Michelle Kim, Yoshie Umemura, Hugh Garton, Andrea Franson, Patricia Robertson, Jonathan Schwartz, Bernard Marini, Manjunath Pai, Timothy Phoenix, Sunjong Ji, Evan Cantor, Zachary Miklja, Brendan Mullan, Amy Bruzek, Ruby Siada, Jessica Cummings, Stefanie Stallard, Kyle Wierzbicki, Alyssa Paul, Ian Wolfe, Matthew Dun, Jason Cain, Li Jiang, Mariella Filbin, Pankaj Vats, Chandan Kumar-Sinha, Rajen Mody, Arul Chinnaiyan, Drew Pratt, Sriram Venneti, Guangrong Lu, Sabine Mueller, Adam Resnick, Javad Nazarian, Sebastian Waszak, Joshua Allen
Patients with diffuse midline glioma (DMG) harboring H3 K27M mutation have no proven therapies beyond radiation. ONC201, a DRD2 antagonist and mitochondrial ClpP agonist, has induced early responses in patients with H3 K27M-mutant DMG. We performed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06f1acf7b9e4e63c9e411b7056b9a949
https://doi.org/10.21203/rs.3.rs-69706/v1
https://doi.org/10.21203/rs.3.rs-69706/v1