Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Brendan M. Duggan"'
Autor:
Elaine Woodward, Brendan M. Duggan
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 421 (2024)
Abnormal blood coagulation is a major health problem and natural anticoagulants from blood-feeding organisms have been investigated as novel therapeutics. NAPc2, a potent nematode-derived inhibitor of coagulation, has an unusual mode of action that r
Externí odkaz:
https://doaj.org/article/60681886df9e47bca637d137f37442cb
Publikováno v:
Marine Drugs, Vol 21, Iss 2, p 56 (2023)
As one of the first families of marine natural products to undergo clinical trials, the didemnin depsipeptides have played a significant role in inspiring the discovery of marine drugs. Originally developed as anticancer therapeutics, the recent re-e
Externí odkaz:
https://doaj.org/article/ef827ce5676c4de0a82d59de9de787c0
Publikováno v:
mSystems, Vol 5, Iss 2 (2020)
ABSTRACT Next-generation sequencing studies of saliva and dental plaque from subjects in both healthy and diseased states have identified bacteria belonging to the Rothia genus as ubiquitous members of the oral microbiota. To gain a deeper understand
Externí odkaz:
https://doaj.org/article/fa03b0ca152f4006b59944c643a5be70
Higher heritabilities for gait components than for overall gait scores may improve mobility in ducks
Publikováno v:
Genetics Selection Evolution, Vol 49, Iss 1, Pp 1-7 (2017)
Abstract Background Genetic progress in selection for greater body mass and meat yield in poultry has been associated with an increase in gait problems which are detrimental to productivity and welfare. The incidence of suboptimal gait in breeding fl
Externí odkaz:
https://doaj.org/article/0a50fbbda56a45f0abc7e66920e49683
Autor:
Brendan M. Duggan
Publikováno v:
Molecules, Vol 25, Iss 2, p 327 (2020)
Natural product research continues to be a productive source of unusual chemistry, producing novel compounds for biomedical applications and, increasingly, sustainably providing commercially useful compounds [...]
Externí odkaz:
https://doaj.org/article/17a180eb98164c72b9f0e91c9b21b22a
Autor:
Aubrie O’Rourke, Stephan Kremb, Brendan M. Duggan, Salim Sioud, Najeh Kharbatia, Misjudeen Raji, Abdul-Hamid Emwas, William H. Gerwick, Christian R. Voolstra
Publikováno v:
Molecules, Vol 23, Iss 6, p 1472 (2018)
Viruses are underrepresented as targets in pharmacological screening efforts, given the difficulties of devising suitable cell-based and biochemical assays. In this study we found that a pre-fractionated organic extract of the Red Sea sponge Amphimed
Externí odkaz:
https://doaj.org/article/b6c39086d37f46f3a9b561e052f643ef
Autor:
Nhan T. Pham, Joana Alves, Fiona A. Sargison, Reiko Cullum, Jan Wildenhain, William Fenical, Mark S. Butler, David A. Mead, Brendan M. Duggan, J. Ross Fitzgerald, James J. La Clair, Manfred Auer
Antimicrobial resistance has emerged as an urgent global public health threat, and development of novel therapeutics for treating infections caused by multi-drug resistant bacteria is urgent.Staphylococcus aureusis a major human and animal pathogen,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03f75102ea39e05cdde7ce4b15606bdb
https://doi.org/10.1101/2022.12.04.519019
https://doi.org/10.1101/2022.12.04.519019
Autor:
Zhibin Liang, David Soriano-Castell, Devin Kepchia, Brendan M. Duggan, Antonio Currais, David Schubert, Pamela Maher
Publikováno v:
Free Radic Biol Med
The oxytosis/ferroptosis regulated cell death pathway recapitulates many features of mitochondrial dysfunction associated with the aging brain and has emerged as a potential key mediator of neurodegeneration. It has thus been proposed that the oxytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acd9267a6010d9f8fafb64594b55544
https://europepmc.org/articles/PMC9116140/
https://europepmc.org/articles/PMC9116140/
Publikováno v:
J Comput Aided Mol Des
We investigate the binding of native β-cyclodextrin (β-CD) and eight novel β-CD derivatives with two different guest compounds, using isothermal calorimetry (ITC) and 2D NOESY NMR. In all cases, the stoichiometry is 1:1 and binding is exothermic.
Autor:
Zhibin Liang, David Soriano-Castell, Devin Kepchia, Brendan M. Duggan, Antonio Currais, David Schubert, Pamela Maher
Publikováno v:
Free Radic Biol Med
The oxytosis/ferroptosis regulated cell death pathway recapitulates many features of mitochondrial dysfunction associated with the aging brain and has emerged as a potential key mediator of neurodegeneration. It has thus been proposed that the oxytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be6f6257309d279eac4521b0c150bb3
https://europepmc.org/articles/PMC8840979/
https://europepmc.org/articles/PMC8840979/