Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Brendan Leighton"'
Autor:
Marianne G. Pouwer, Suvi E. Heinonen, Margareta Behrendt, Anne-Christine Andréasson, Arianne van Koppen, Aswin L. Menke, Elsbet J. Pieterman, Anita M. van den Hoek, J. Wouter Jukema, Brendan Leighton, Ann-Cathrine Jönsson-Rylander, Hans M. G. Princen
Publikováno v:
Journal of Diabetes Research, Vol 2019 (2019)
Background. There is a lack of predictive preclinical animal models combining atherosclerosis and type 2 diabetes. APOE∗3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase+/− (GK+/
Externí odkaz:
https://doaj.org/article/fcb568a4dba0410dbde997fd34268ac7
Autor:
Damilola D. Adingupu, Suvi E. Heinonen, Anne-Christine Andréasson, Mikael Brusberg, Andrea Ahnmark, Margareta Behrendt, Brendan Leighton, Ann-Cathrine Jönsson-Rylander
Publikováno v:
Journal of Diabetes Research, Vol 2016 (2016)
Aim. Models combining diabetes and atherosclerosis are important in evaluating the cardiovascular (CV) effects and safety of antidiabetes drugs in the development of treatments targeting CV complications. Our aim was to evaluate if crossing the heter
Externí odkaz:
https://doaj.org/article/ecc3d17e5ed04a3f99edd95ddbcc466d
Autor:
Margareta Behrendt, Arianne van Koppen, Suvi E. Heinonen, Ann-Cathrine Jönsson-Rylander, Anne-Christine Andréasson, Aswin L. Menke, Hans M.G. Princen, Brendan Leighton, Marianne G. Pouwer, Anita M. van den Hoek, J. Wouter Jukema, Elsbet J. Pieterman
Publikováno v:
Journal of Diabetes Research. 2019:1-13
Background. There is a lack of predictive preclinical animal models combining atherosclerosis and type 2 diabetes. APOE∗3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase+/− (GK+/
Autor:
Christophe, Fromont, Alessio, Atzori, Divneet, Kaur, Lubna, Hashmi, Graziella, Greco, Alejandro, Cabanillas, Huy Van, Nguyen, D Heulyn, Jones, Miguel, Garzón, Ana, Varela, Brett, Stevenson, Greg P, Iacobini, Marc, Lenoir, Sundaresan, Rajesh, Clare, Box, Jitendra, Kumar, Paige, Grant, Vera, Novitskaya, Juliet, Morgan, Fiona J, Sorrell, Clara, Redondo, Andreas, Kramer, C John, Harris, Brendan, Leighton, Steven P, Vickers, Sharon C, Cheetham, Colin, Kenyon, Anna M, Grabowska, Michael, Overduin, Fedor, Berditchevski, Chris J, Weston, Stefan, Knapp, Peter M, Fischer, Sam, Butterworth
Publikováno v:
Journal of Medicinal Chemistry
Polymorphisms in the region of the calmodulin-dependent kinase isoform D (CaMK1D) gene are associated with increased incidence of diabetes, with the most common polymorphism resulting in increased recognition by transcription factors and increased pr
Autor:
Fedor Berditchevski, Lubna Hashmi, Stevenson Brett W, Graziella Greco, Juliet Morgan, Alessio Atzori, Sundaresan Rajesh, Anna M. Grabowska, Divneet Kaur, Ana Varela, Alejandro Cabanillas, Huy V. Nguyen, Marc Lenoir, Sharon C. Cheetham, Greg P. Iacobini, Colin Kenyon, Christopher J. Weston, Christophe Fromont, Clare L. Box, Miguel Garzon, Brendan Leighton, D. Heulyn Jones, Jitendra Kumar, Fiona J. Sorrell, Steven P. Vickers, Sam Butterworth, C. John Harris, Paige Grant, Clara Redondo, Peter Fischer, Michael Overduin, Andreas Krämer, Vera Novitskaya, Stefan Knapp
Publikováno v:
Butterworth, S & Garzon Sanz, M 2020, ' Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model ', Journal of Medicinal Chemistry, vol. 63, no. 13, pp. 6784-6801 . https://doi.org/10.1021/acs.jmedchem.9b01803
Journal of medicinal chemistry 63(13), 6784-6801 (2020). doi:10.1021/acs.jmedchem.9b01803
Journal of medicinal chemistry 63(13), 6784-6801 (2020). doi:10.1021/acs.jmedchem.9b01803
Polymorphisms in the region of the calmodulin-dependent kinase isoform D (CaMK1D) gene are associated with increased incidence of diabetes, with the most common polymorphism resulting in increased recognition by transcription factors and increased pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5530ea1a6282165c274343b752573f14
https://doi.org/10.1021/acs.jmedchem.9b01803
https://doi.org/10.1021/acs.jmedchem.9b01803
Autor:
Despina Constantin, Dumitru Constantin-Teodosiu, Paul L. Greenhaff, Simon M. Poucher, Craig Porter, Brendan Leighton
Publikováno v:
The Journal of Physiology. 595:5765-5780
Key points Meldonium inhibits endogenous carnitine synthesis and tissue uptake, and accelerates urinary carnitine excretion, although the impact of meldonium-mediated muscle carnitine depletion on whole-body fuel selection, and muscle fuel metabolism
Autor:
Mikaela Sjöstrand, C. Stacey, P. Ceuppens, A. Gyte, P. Morentin Gutierrez, Jan W. Eriksson, Catarina Nilsson, Brendan Leighton, Joanne deSchoolmeester, John G. Swales
Publikováno v:
British Journal of Pharmacology. 172:4806-4816
Background and Purpose11-hydroxysteroid dehydrogenase type I (11-HSD1), a target for Type 2 diabetes mellitus, converts inactive glucocorticoids into bioactive forms, increasing tissue concentratio ...
Autor:
Marianne G, Pouwer, Suvi E, Heinonen, Margareta, Behrendt, Anne-Christine, Andréasson, Arianne, van Koppen, Aswin L, Menke, Elsbet J, Pieterman, Anita M, van den Hoek, J Wouter, Jukema, Brendan, Leighton, Ann-Cathrine, Jönsson-Rylander, Hans M G, Princen
Publikováno v:
Journal of Diabetes Research
Background There is a lack of predictive preclinical animal models combining atherosclerosis and type 2 diabetes. APOE∗3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase+/− (GK+/
Autor:
Craig, Porter, Dumitru, Constantin-Teodosiu, Despina, Constantin, Brendan, Leighton, Simon M, Poucher, Paul L, Greenhaff
Publikováno v:
The Journal of physiology. 595(17)
Meldonium inhibits endogenous carnitine synthesis and tissue uptake, and accelerates urinary carnitine excretion, although the impact of meldonium-mediated muscle carnitine depletion on whole-body fuel selection, and muscle fuel metabolism and its mo
Publikováno v:
British Journal of Pharmacology. 171:1629-1641
Background and Purpose The global heterozygous glucokinase (GK) knockout (gkwt/del) male mouse, fed on a high-fat (60% by energy) diet, has provided a robust and reproducible model of hyperglycaemia. This model could be highly relevant to some facets