Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brendan K Reed"'
Autor:
Brendan K Reed, Laura B Chopp, Courtney S Malo, Danielle N Renner, Virginia S Van Keulen, Megan A Girtman, Wendy N Nevala, Kevin D Pavelko, Diana Gil, Adam G Schrum, Aaron J Johnson, Larry R Pease
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137984 (2015)
Antigen-specific T cell responses can be visualized using MHC:peptide multimers. In cases where robust T cell controls are not readily available to assess the integrity of multimer reagents prior to analyzing limited sample, the ability to assess the
Externí odkaz:
https://doaj.org/article/1fb448f2255f452cad3fed8f44b99cae
Autor:
Brendan K. Reed, John W. Kappler
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The T cell antigens driving autoimmune Type 1 Diabetes (T1D) have been pursued for more than three decades. When diabetogenic CD4 T cell clones and their relevant MHCII antigen presenting alleles were first identified in rodents and humans, the path
Externí odkaz:
https://doaj.org/article/ea66b09c17dd4ef2a8efed330a2a7481
Autor:
Ryan C. Hill, Frances Crawford, S. Harsha Krovi, Kirk C. Hansen, John W. Kappler, Philippa Marrack, Janice White, Niyun Jin, Brendan K Reed
Publikováno v:
The Journal of Experimental Medicine
The lysosomal protease cathepsin L uses pancreatic secretory granule protein precursors and a reverse proteolysis mechanism, transpeptidation, to generate chimeric super-epitopes specific for diabetogenic CD4 T cells.
The identification of the p
The identification of the p
Autor:
Brendan K. Reed, Andrew J. Bordner, David M. Kranz, Michael A. Barry, Kalli R. Henning, Diana Gil, Adam G. Schrum, Virginia P. Van Keulen, Michael J. Hansen, Kevin D. Pavelko, Larry R. Pease, Christopher A. Parks, Jennifer D. Stone
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(8)
Successful efforts to activate T cells capable of recognizing weak cancer-associated self-antigens have employed altered peptide antigens to activate T cell responses capable of cross-reacting on native tumor-associated self. A limitation of this app
Autor:
Rochelle R. Torgerson, Brendan K. Reed, Diana Gil, Jeanette E. Eckel-Passow, Stephen E. P. Smith, Jason P. Sinnwell, Steven C. Neier, Adam G. Schrum, Carilyn N. Wieland, Gabriel F. Sciallis, Claudia Neuhauser, Tessa R. Davis
Multiprotein complexes transduce cellular signals through extensive interaction networks, but the ability to analyze these networks in cells from small clinical biopsies is limited. To address this, we applied an adaptable multiplex matrix system to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d69904b09b9ddb297e94e1181a0c3e
https://europepmc.org/articles/PMC5336380/
https://europepmc.org/articles/PMC5336380/
The αβ T cell antigen receptor (TCR) endows T lymphocytes with immune specificity and controls their effector functions. Each person possesses a vast repertoire of TCRs that is generated by the well-studied processes of somatic recombination and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21ef1d839421786a697708ebd7fe415
https://europepmc.org/articles/PMC4278167/
https://europepmc.org/articles/PMC4278167/
Autor:
Alfredo Oliveros, Brendan K. Reed, Christopher A. Parks, Robert J. Stiles, Katelynn M. Wilton, Maja Radulovic, Adam G. Schrum, Steven C. Neier, Alejandro Ferrer, Macarena Gil-Pagés
Publikováno v:
Behavioral and Brain Functions : BBF
Background There is significant interest in the generation of improved assays to clearly identify experimental mice possessing functional vision, a property that could qualify mice for inclusion in behavioral and neuroscience studies. Widely employed