Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Brendan J. McMorran"'
Autor:
Vignesh Arunachalam, Rodney Lea, Wendy Hoy, Simon Lee, Susan Mott, Judith Savige, John D. Mathews, Brendan J. McMorran, Shivashankar H. Nagaraj
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Chronic kidney disease (CKD) is highly prevalent among Indigenous Australians, especially those in remote regions. The Tiwi population has been isolated from mainland Australia for millennia and exhibits unique genetic characteris
Externí odkaz:
https://doaj.org/article/92fe68ebd55645deb7e72c2fd290eb91
Autor:
Sumudu Rangika Samarasinghe, Wendy Hoy, Sudhir Jadhao, Brendan J. McMorran, Henk-Jan Guchelaar, Shivashankar H. Nagaraj
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Population genomic studies of individuals of Indigenous ancestry have been extremely limited comprising
Externí odkaz:
https://doaj.org/article/45fa476846004b3aa78333c77b5f2963
Autor:
Cilly Bernardette Schnider, Hao Yang, Lora Starrs, Anna Ehmann, Farid Rahimi, Elena Di Pierro, Giovanna Graziadei, Kathryn Matthews, Tania De Koning-Ward, Denis C. Bauer, Simon J. Foote, Gaetan Burgio, Brendan J. McMorran
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
An important component in host resistance to malaria infection are inherited mutations that give rise to abnormalities and deficiencies in erythrocyte proteins and enzymes. Understanding how such mutations confer protection against the disease may be
Externí odkaz:
https://doaj.org/article/31219ec1b0fd46b18dc218d00ec47b2c
Autor:
Dian Ningtyas, Russell J. Thomson, Volga Tarlac, Shivashankar H. Nagaraj, Wendy Hoy, John D. Mathews, Simon J. Foote, Elizabeth E. Gardiner, Justin R. Hamilton, Brendan J. McMorran
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
The F2RL3 gene encoding protease activated receptor 4 (PAR4) contains a single nucleotide variant, rs773902, that is functional. The resulting PAR4 variants, Thr120, and Ala120, are known to differently affect platelet reactivity to thrombin. Signifi
Externí odkaz:
https://doaj.org/article/7750e3e3a71b4504a0c4bf25224be957
Autor:
Patrick M. Lelliott, Hong Ming Huang, Matthew W. Dixon, Arman Namvar, Adam J. Blanch, Vijay Rajagopal, Leann Tilley, Cevayir Coban, Brendan J. McMorran, Simon J. Foote, Gaetan Burgio
Publikováno v:
Blood Advances, Vol 1, Iss 26, Pp 2624-2636 (2017)
Abstract: The malaria parasite hijacks host erythrocytes to shield itself from the immune system and proliferate. Red blood cell abnormalities can provide protection from malaria by impeding parasite invasion and growth within the cell or by compromi
Externí odkaz:
https://doaj.org/article/b904422884f74753812651a6cc48230a
Autor:
Hong Ming Huang, Denis C. Bauer, Patrick M. Lelliott, Matthew W. A. Dixon, Leann Tilley, Brendan J. McMorran, Simon J. Foote, Gaetan Burgio
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 9, Pp 3133-3144 (2017)
Allelic heterogeneity is a common phenomenon where a gene exhibits a different phenotype depending on the nature of its genetic mutations. In the context of genes affecting malaria susceptibility, it allowed us to explore and understand the intricate
Externí odkaz:
https://doaj.org/article/9bad8ce2bed54c3aaf6b8f0f966deb1b
Autor:
James H. O’Connor, Hayley A. McNamara, Yeping Cai, Lucy A. Coupland, Elizabeth E. Gardiner, Christopher R. Parish, Brendan J. McMorran, Vitaly V. Ganusov, Ian A. Cockburn
Publikováno v:
The Journal of Immunology. 208:2738-2748
Liver-resident CD8+ T cells can play critical roles in the control of pathogens, including Plasmodium and hepatitis B virus. Paradoxically, it has also been proposed that the liver may act as the main place for the elimination of CD8+ T cells at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95401ea3e82160a25570fcbba69009d3
https://doi.org/10.4049/jimmunol.2101037
https://doi.org/10.4049/jimmunol.2101037
Autor:
Isabella R. Palombi, Nicole Lawrence, Andrew M. White, Caitlin L. Gare, David J. Craik, Brendan J. McMorran, Lara R. Malins
Publikováno v:
Bioconjugate Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e2a24749d9c5325a17ed959bceb9faf
https://doi.org/10.1021/acs.bioconjchem.3c00147
https://doi.org/10.1021/acs.bioconjchem.3c00147
Autor:
Bruce A. Munro, Brendan J. McMorran
Publikováno v:
Parasitologia. 2:101-124
Onward transmission of Plasmodium falciparum from humans to mosquitoes is dependent upon a specialised transmission stage called the gametocyte. Despite its critical role in transmission, key questions regarding gametocyte biology remain to be answer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e093fa07d7095def361837a6b9eeede4
https://doi.org/10.3390/parasitologia2020011
https://doi.org/10.3390/parasitologia2020011
Autor:
Brendan J. McMorran, Arvind Jaya Shankar, Simon J. Foote, Vinod Scaria, Sudhir Jadhao, Wendy E. Hoy, Hardip R. Patel, Shivashankar H. Nagaraj
Publikováno v:
The Pharmacogenomics Journal. 22:100-108
Indigenous Australians face a disproportionately severe burden of chronic disease relative to other Australians, with elevated rates of morbidity and mortality. While genomics technologies are slowly gaining momentum in personalised treatments for ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::629eb2852f7eef4e5ca7b236b1d18539
https://doi.org/10.1038/s41397-021-00262-4
https://doi.org/10.1038/s41397-021-00262-4